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    USE OF A PEPTIDE AS A THERAPEUTIC AGENT
    32.
    发明公开
    USE OF A PEPTIDE AS A THERAPEUTIC AGENT 审中-公开
    使用肽作为治疗剂

    公开(公告)号：EP2187951A2

    公开(公告)日：2010-05-26

    申请号：EP08802090.4

    申请日：2008-09-09

    申请人： Mondobiotech Laboratories AG

    发明人： BEVEC, Dorian ,  CAVALLI, Fabio ,  CAVALLI, Vera ,  BACHER, Gerald

    IPC分类号： A61K38/33 ,  A61P35/00 ,  A61P37/00 ,  A61P25/28 ,  A61P31/00 ,  A61P11/00 ,  A61P9/00 ,  A61P3/00 ,  A61P31/04

    CPC分类号： A61K38/12 ,  Y02A50/385 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/422 ,  Y02A50/423 ,  A61K2300/00

    摘要： The present invention is directed to the use of the peptide compound Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe-Pro-Pro-Gly-His-Phe-Lys-Asp-Pro-Lys-Arg-Leu-Tyr as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe-Pro-Pro-Gly-His-Phe-Lys-Asp-Pro-Lys-Arg-Leu-Tyr optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

    摘要翻译： 本发明涉及肽化合物Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-OH作为治疗剂用于预防和/或治疗 癌症，自身免疫性疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺病，心脏和血管疾病以及代谢疾病。 此外，本发明涉及优选以冻干物或液体缓冲溶液或人造母乳制剂或母乳代用品形式的药物组合物，其含有肽Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys- Val-Val-Thr-OH任选与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂一起使用。