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    HYDROGEL-FORMING MATERIAL
    9.
    发明公开
    HYDROGEL-FORMING MATERIAL 审中-公开
    氢化物质

    公开(公告)号：EP2905016A1

    公开(公告)日：2015-08-12

    申请号：EP13843933.6

    申请日：2013-10-02

    申请人： Nissan Chemical Industries, Ltd.

    发明人： MATSUMOTO, Keigo

    IPC分类号： A61K9/06 ,  A61K47/12 ,  A61K47/42

    CPC分类号： A61K8/361 ,  A23L29/20 ,  A23V2002/00 ,  A23V2250/55 ,  A61K8/042 ,  A61K8/64 ,  A61K9/06 ,  A61K47/12 ,  A61K47/183 ,  A61K47/42 ,  A61K2800/10 ,  A61Q19/00 ,  A23V2250/54

    摘要： There is provided a hydrogel-forming material in which a hydrogel can be formed in preparation of the hydrogel even after a process of stirring a gelator in a medium with heating to dissolve and disperse the gelator, and cooling the mixture to room temperature with stirring, and a hydrogel material in which a gel can be reformed by standing at room temperature even after a hydrogel obtained using the material is converted into a sol by shaking.
    A hydrogel-forming material comprising a lipid peptide gelator consisting of a compound of Formula (1) or a pharmaceutically usable salt thereof:

    (wherein, R 1 is a C 9-23 aliphatic group, R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1-2 branched chain, R 3 is a -(CH 2 ) n -X group, n is a number of 1 to 4, and X is an amino group, a guanidino group, a -CONH 2 group, a 5-membered ring optionally having 1 to 3 nitrogen atom(s), a 6-membered ring optionally having 1 to 3 nitrogen atom(s), or a fused heterocycle composed of a 5-memberd ring and a 6-membered ring optionally having 1 to 3 nitrogen atom(s)), water, and a fatty acid salt as an additive.

    摘要翻译： 提供了一种水凝胶形成材料，其中即使在加热介质中搅拌凝胶剂以溶解和分散凝胶剂之后，也可以在制备水凝胶中形成水凝胶，并在搅拌下将混合物冷却至室温， 以及即使在使用该材料获得的水凝胶通过摇动将溶胶转化为溶胶后，也可以在室温下静置使凝胶重整的水凝胶材料。 一种水凝胶形成材料，其包含由式（1）的化合物或其药学上可用的盐组成的脂质肽胶凝剂（其中，R 1为C 9-23脂肪族基团，R 2为氢原子或C 1 -4-烷基，任选具有C 1-2支链，R 3为 - （CH 2）n -X基，n为1至4的数，X为氨基，胍基， CONH 2基团，任选具有1至3个氮原子的5元环，任选具有1至3个氮原子的6元环或由5元环和6个氮原子组成的稠合杂环 具有1至3个氮原子的环状环），水和作为添加剂的脂肪酸盐。