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31.发明公开INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES 有权GSK-3 GSK-3β蛋白和-PROTEINKOMPLEXEN的抑制剂，晶体结构
公开(公告)号：EP1435957A4
公开(公告)日：2005-04-13
申请号：EP02729056
申请日：2002-04-29
申请人： VERTEX PHARMA
IPC分类号： G01N23/20 , A61K31/5025 , A61P3/10 , A61P9/10 , A61P11/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P29/00 , A61P37/08 , A61P43/00 , C07D487/04 , C12N9/12 , C12N9/99 , C12Q1/48 , G06F19/16 , A61K31/495 , A61K31/50
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
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公开(公告)号：EP3294717A1
公开(公告)日：2018-03-21
申请号：EP16725308
申请日：2016-05-11
申请人： VERTEX PHARMA
IPC分类号： C07D239/42 , C07D471/04
CPC分类号： C07D471/04 , C07D239/42
摘要： in the presence of water, an organic solvent, a base, and a transition metal catalyst to generate a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
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33.发明公开NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION 审中-公开选择性AURORA-A-NEW抑制氨基吡啶衍生物
公开(公告)号：EP2411011A4
公开(公告)日：2012-08-15
申请号：EP10756584
申请日：2010-03-15
申请人： MSD KK , VERTEX PHARMA
IPC分类号： C07D401/04 , A61K31/506 , A61P35/00 , C07D413/14
CPC分类号： A61K31/535 , C07D401/14 , C07D417/14
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34.发明公开SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权FESTE FORMEN VON N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧杂环辛烷-3-羧酸
公开(公告)号：EP1993360A4
公开(公告)日：2010-12-01
申请号：EP06848237
申请日：2006-12-28
申请人： VERTEX PHARMA
发明人： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC分类号： C07D215/56 , A61K31/445
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：EP1644497A4
公开(公告)日：2007-08-08
申请号：EP04801966
申请日：2004-07-08
申请人： VERTEX PHARMA
IPC分类号： C12N15/00 , C12N15/63 , G01N25/18 , G01N33/487 , G01N33/50 , G01N33/566 , G01N33/68
CPC分类号： G01N33/5038 , G01N33/48728 , G01N33/5008 , G01N33/5076 , G01N33/5088 , G01N33/542 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
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36.发明公开CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE 2 AND BINDING POCKETS THEREOF 审中-公开蛋白质有丝分裂原的晶体结构，激酶活化蛋白激酶2和结合口袋THEREOF-
公开(公告)号：EP1461758A4
公开(公告)日：2005-10-05
申请号：EP02799215
申请日：2002-12-05
申请人： VERTEX PHARMA
发明人： MENG WUYI , SWENSON LOVORKA
IPC分类号： C12N9/12 , C12Q1/48 , G01N33/48 , G01N33/50 , G01N33/573 , G06F19/16 , G06G7/48 , A61K39/00 , G06G7/58
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/573 , G06F19/16
摘要： The invention relates to crystalline molecules or molecular complexes that comprise binding pockets of mitogen activated protein kinase activated protein kinase 2 (MAPKAPK2) or its homologues. The invention also relates to crystals comprising MAPKAPK2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of MAPKAPK2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, design and optimize compounds, including agonists and antagonists, which bind to MAPKAPK2 or homologues thereof.
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37.发明公开INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-Jun N-末端激酶（JNK）AND OTHER蛋白抑制剂KINASES-
公开(公告)号：EP1218369A4
公开(公告)日：2005-06-22
申请号：EP00957485
申请日：2000-08-11
申请人： VERTEX PHARMA
发明人： GREEN JEREMY , BEMIS GUY , GRILLOT ANNE-LAURE , LEDEBOER MARK , SALITURO FRANCIS , HARRINGTON EDMUND , GAO HUAI , BAKER CHRISTOPHER , CAO JINGRONG , HALE MICHAEL
IPC分类号： A61K31/341 , A61K31/4155 , A61K31/4192 , A61K31/42 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D401/04 , C07D403/04 , C07D405/04
CPC分类号： C07D413/04 , A61K31/341 , A61K31/4155 , A61K31/4192 , A61K31/42 , C07D413/14
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公开(公告)号：EP1162884A4
公开(公告)日：2002-07-24
申请号：EP00916478
申请日：2000-03-17
申请人： VERTEX PHARMA
发明人： CHATURVEDI PRAVIN , SU MICHAEL , TUNG ROGER
IPC分类号： A61K47/00 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/222 , A61K31/25 , A61K31/27 , A61K45/00 , A61K45/06 , A61K47/48 , A61K48/00 , A61P1/00 , A61P7/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61K31/19 , A61P11/00
CPC分类号： A61K45/06 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/222 , A61K31/25
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