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31.发明公开
公开(公告)号：EP2131919A4
公开(公告)日：2010-10-20
申请号：EP08733073
申请日：2008-04-02
CPC分类号： A61N1/0556 , A61B5/0031 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4052 , A61B5/4519 , A61B5/686 , A61L2400/18 , A61L2430/32 , A61N1/326 , A61N1/36042
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公开(公告)号：EP1848501A1
公开(公告)日：2007-10-31
申请号：EP06717313.8
申请日：2006-01-04
申请人： Medtronic,Inc.
发明人： SOYKAN, Orhan , DENO, Curtis, D.
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36042 , A61N1/3684
摘要： In general, the invention is directed to methods and devices for electrically stimulating heart tissue. The invention includes delivery of stimulation to transplanted biological material, such as transplanted cells, transplanted in a myocardium of a heart during an ejection phase of a cardiac cycle. The invention also includes delivery of cardiac potentiation therapy stimulation, which improves the hemodynamic performance of the heart. Stimulation to transplanted biological material and cardiac potentiation therapy stimulation can improve the performance of a heart damaged by myocardial infarction.
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公开(公告)号：EP1061997B1
公开(公告)日：2004-06-16
申请号：EP99906904.0
申请日：1999-02-10
申请人： Medtronic Inc.
发明人： GOEDEKE, Steven, D.
CPC分类号： A61N1/37252 , A61B5/002 , A61B5/0031 , A61B5/02055 , A61B5/02156 , A61B5/042 , A61B5/1455 , A61B2560/0209 , A61N1/36042 , A61N1/3621 , A61N1/3655 , A61N1/36585 , A61N1/371 , A61N1/3962 , G06F19/00
摘要： A patient monitoring and/or therapy delivery system and method employing an implantable medical device for sensing absolute physiologic signal values within the body of a patient, e.g., absolute blood pressure, temperature, etc., and an external monitoring device for monitoring and conveying ambient signal values to the implantable medical device, wherein the absolute physiologic signal values and the ambient signal values are combined to derive relative physiologic signal values for storage and/or control of a therapy provided by the implantable medical device. In the context of an implantable physiologic monitor, the relative and optionally, the absolute and/or ambient physiologic signal values are stored in memory for telemetry out to an external programmer in an uplink RF telemetry transmission initiated by medical personnel operating the external programmer. In the context of an implantable therapy delivery device, the relative physiologic signal values are also employed in therapy delivery algorithms.
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公开(公告)号：EP1315537A1
公开(公告)日：2003-06-04
申请号：EP00978392.9
申请日：2000-11-03
申请人： Medtronic Inc. , Donovan, Maura G. , Soykan, Orhan
发明人： DONOVAN, Maura, G. , SOYKAN, Orhan
IPC分类号： A61N1/36
CPC分类号： A61N1/36042
摘要： An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated and/or differentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium or otherwise damaged or diseased myocardial tissue.
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公开(公告)号：EP0587269B1
公开(公告)日：1998-12-16
申请号：EP93304255.8
申请日：1993-06-01
申请人： TELECTRONICS N.V.
发明人： Bui, Tuan Sy
IPC分类号： A61N1/36
CPC分类号： A61N1/36042 , A61M1/1003 , A61M1/1008 , A61M1/1053 , A61M1/1067 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61N1/08 , A61N1/3627
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公开(公告)号：EP0759312A3
公开(公告)日：1998-05-27
申请号：EP96305736
申请日：1996-08-02
申请人： MEDTRONIC INC
CPC分类号： A61N1/3621 , A61N1/36042 , A61N1/3962
摘要： A cardiac assist device having muscle augmentation after a confirmed arrhythmia. In particular the present invention operates, in a first embodiment, to sense a cardiac event, next it determines whether the cardiac event is a cardiac arrhythmia, if the event is not a cardiac arrhythmia the devices delivers stimulation to a skeletal muscle grafted about a heart, but if the event is a cardiac arrhythmia the device inhibits delivery of skeletal muscle stimulation and once the arrhythmia is confirmed, then delivers therapeutic stimulation to the heart. In a second embodiment the present invention operates to re-initiate skeletal muscle stimulation once the arrhythmia is confirmed but prior to the delivery of the therapeutic stimulation to the heart.
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公开(公告)号：EP0722348A1
公开(公告)日：1996-07-24
申请号：EP94926622.0
申请日：1994-08-26
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/3708 , A61N1/36042
摘要： An end-of-life (EOL) indicator for an implantable pulse generator (IPG) - especially of the neuromuscular stimulation variety - indicates an approaching battery EOL condition via an electrocardiogram (ECG) by changing the nature of the muscle stimulation burst signals. IPG internal circuitry detects an approaching EOL condition and modifies the burst signals by, for example, decreasing the number of pulses in a burst, increasing the heart contraction-to-powering-muscle contraction ratio, or alternating between two numbers of pulses in successive burst cycles. The approaching battery EOL condition can be easily ascertained via trans-telephonic monitoring by analyzing a transmitted ECG alone, for the above-mentioned burst signal changes. By observing the patterns in the ECG caused by the burst signal changes, a clinician could be aware of an approaching EOL without having known the original muscle stimulation burst signal parameters.
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公开(公告)号：EP0553123B1
公开(公告)日：1995-03-15
申请号：EP91917171.0
申请日：1991-09-19
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/36042 , A61M1/1003 , A61M1/1046 , A61M1/1053 , A61M1/1067 , A61M1/1068 , A61M1/12 , A61M1/122 , A61M1/127
摘要： A method and apparatus for providing assistance to a patient's heart using a surgically prepared skeletal muscle. A skeletal muscle, such as the latissimus dorsi, is carefully separated from the skeletal structure leaving innervation and vascularization intact. The muscle tissue is then separated into two independent contractile masses. Alternatively, two separate skeletal muscles may be used. The first of these is wrapped about the atria. The second is wrapped about the ventricles. Each muscle mass is individually stimulated using an implantable pulse generator. Stimulation to the muscle mass is synchronized to the naturally or artificially paced contractions of the heart to provide the maximum in assistance. During each complete heart cycle, the muscle mass assisting the ventricles is stimulated at the same time as contraction of the ventricular myocardium. The muscle mass assisting the atria is then stimulated at the same time as contraction of the atrial myocardium. Various sensing and stimulating modes may be used to optimize cardiac assistance.
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39.发明公开An arrhythmia control pacer using skeletal muscle cardiac graft stimulation 失效Durch Reizung von einem implantierten Skelettmuskelstransplantat arbeitendesArrhythmiekontrollgerät。
公开(公告)号：EP0547733A2
公开(公告)日：1993-06-23
申请号：EP92306759.9
申请日：1992-07-23
申请人： TELECTRONICS N.V.
CPC分类号： A61N1/36042 , A61M1/1003 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61N1/3621 , A61N1/3627 , A61N1/3962
摘要： An antiarrhythmia pacemaker (17) and method detect and confirm the occurrence of an abnormal condition of a patient's heart selected from the group comprising tachycardia, fibrillation and precursors thereof, and, in response thereto, deliver an antiarrhythmia therapy to the patient which includes two components, electrical stimulation of the heart and electrical stimulation of a skeletal muscle graft (9) which has been surgically grafted to the heart to augment performance of the heart. The antiarrhythmia pacemaker (17) and method control electrical stimulation of the heart in terms of timing, frequency, amplitude, duration and other operational parameters, to provide such pacing therapies as antitachycardia pacing, cardioversion and defibrillation. A skeletal muscle graft stimulation electrode, which is driven by a skeletal muscle pulse stimulator (20) stimulates preselected nerve fibers within the skeletal muscle graft (9). An arrhythmia therapy control responds to the detection and confirmation of an abnormal heart condition by controlling and coordinating the operation of the heart stimulator and the skeletal muscle graft stimulator (20) to direct performance of a combined heart stimulation and skeletal muscle graft stimulation therapy.
摘要翻译： 抗心律失常起搏器和方法检测并确认选自包括心动过速，原纤维化及其前体的组的患者心脏的异常状况的发生，并且响应于此，向包括两个组分的患者的电刺激递送抗心律失常疗法 的心脏和电刺激的骨骼肌移植物已被手术移植到心脏以增强心脏的表现。 抗心律失常起搏器和方法控制心脏在时间，频率，幅度，持续时间和其他手术参数方面的电刺激，以提供如心动过速起搏，心脏复律和除颤的这种起搏疗法。 由骨骼肌脉冲刺激器（20）驱动的骨骼肌移植物刺激电极刺激骨骼肌移植物中预选的神经纤维（9）。 心律失常治疗控制通过控制和协调心脏刺激器和骨骼肌移植刺激器（20）的操作来响应异常心脏病状的检测和确认，以指导组合心脏刺激和骨骼肌移植刺激治疗的表现。
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公开(公告)号：EP0536858A1
公开(公告)日：1993-04-14
申请号：EP92250257.0
申请日：1992-09-14
CPC分类号： A61M1/10 , A61M1/1003 , A61N1/36042
摘要： Das Stimulationssystem für einen Skelettmuskel, besteht aus einem programmierbarem Herzschrittmacher (2), aus einer programmierbaren Auswerteschaltung (4), aus einem einstellbarem Synchronisierteil (5) zur Synchonisation der Stimulierungsimpulse zum Zeitpunkt t st , einer Programmiereinheit (3) und aus einer programmierbaren Signalverarbeitungsschaltung (1), die über die, insbesondere als Decoder ausgeführte, Auswerteschaltung (4) und den, insbesondere als Dividierer ausgeführten, Synchronisierteil (5) an die Ausgänge des Herzschrittmachers (2) angeschlossen ist. Dabei werden Stimulationsimpulse für mindestens zwei in dem Skelettmuskel LDM implantierbare Elektroden (E1 bis En) mit einer Stimulationsintensität erzeugt, die entsprechend einer für die aktuelle körperliche Belastung bzw. den kardiovaskulären Bedarf repräsentativen Größe nachgeführt wird. Die reizwirksamen Parameter Impulsbreite T p und Impulsamplitude U, bei einem vorgegebenem Impulsintervall T i und einer mit dem Stimulationsmodus m eingestellten Burstdauer T B , werden durch die aus dem Zustand des autonomen Nervensystems direkt oder indirekt abgeleitete Größe, insbesondere der Herzrate HR, bedarfsgemäß automatisch eingestellt.
摘要翻译： 该系统包括可编程评估电路（4）的可编程起搏器（2），用于在时间tst同步刺激脉冲的可调同步部分（5），编程单元（3）和可编程信号处理 电路（1）经由特别构造为解码器的评估电路（4）连接，同步部分（5）特别构成起搏器（2）的输出。 在这种布置中，对于可以植入骨骼肌LDM中的至少两个电极（E1至En）产生刺激脉冲，其刺激强度根据表示当前身体负荷或心血管的量值来校正 需求。 通过刺激模式m设定的具有预定脉冲间隔Ti和突发持续时间TB的刺激效应，脉冲宽度Tp和脉冲幅度U的参数根据由直接或间接导出的量值的需求自动设定 自主神经系统的状态，特别是心率HR。
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