公开(公告)号：EP4406567A3

公开(公告)日：2024-10-09

申请号：EP24169126.0

申请日：2019-01-28

申请人： Axon Therapies, Inc.

发明人： PANESCU, Dorin ,  WU, Andrew ,  ENGELMAN, Zoar Jacob ,  GELFAND, Mark ,  LEUNG, Mark

IPC分类号： A61M25/00 ,  A61B18/14 ,  A61M5/158

CPC分类号： A61M5/158 ,  A61B18/1492 ,  A61B2018/0043420130101 ,  A61B2018/142720130101 ,  A61B2018/14320130101 ,  A61B2090/37620130101 ,  A61B2090/396620160201 ,  A61B2018/021220130101 ,  A61B2018/026220130101 ,  A61B2018/0079120130101 ,  A61B2018/0028520130101 ,  A61B2018/0027320130101 ,  A61B2018/002220130101 ,  A61B2018/0002320130101 ,  A61B2218/00220130101 ,  A61B2018/0002920130101 ,  A61N7/022 ,  A61B2018/0026720130101 ,  A61B2090/06420160201 ,  A61N1/0551 ,  A61N1/36017 ,  A61B5/4041 ,  A61B5/4836

摘要： Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：EP3900607B1

公开(公告)日：2024-07-24

申请号：EP20212396.4

申请日：2016-09-02

IPC分类号： A61B1/00 ,  A61B17/56 ,  A61B1/012 ,  A61B1/05 ,  A61B1/07 ,  A61B1/12 ,  A61B1/313 ,  A61B1/317 ,  A61B17/16 ,  A61B17/17 ,  A61B17/32 ,  A61B17/34 ,  A61F2/46 ,  A61B5/06 ,  A61B90/50 ,  A61B17/70 ,  A61B5/00 ,  A61B18/18 ,  A61B5/24 ,  A61F2/44 ,  A61B17/02 ,  A61B18/00 ,  A61B34/20 ,  A61B17/3205 ,  A61B17/00 ,  A61B90/00 ,  A61B90/57 ,  A61B90/30

CPC分类号： A61B17/0293 ,  A61B17/3421 ,  A61B17/3439 ,  A61B2017/0026120130101 ,  A61B2017/026220130101 ,  A61B2017/345420130101 ,  A61B2017/34820130101 ,  A61B2034/205520160201 ,  A61B2090/0802120160201 ,  A61B1/317 ,  A61B17/025 ,  A61B17/1671 ,  A61B17/320016 ,  A61B17/32053 ,  A61B17/7032 ,  A61B90/361 ,  A61B90/50 ,  A61B2017/025620130101 ,  A61B2017/160220130101 ,  A61B2017/344520130101 ,  A61B2090/03720160201 ,  A61B2090/398320160201 ,  A61B1/00103 ,  A61B1/00135 ,  A61B1/00149 ,  A61B1/00154 ,  A61B1/012 ,  A61B1/05 ,  A61B1/3135 ,  A61B5/068 ,  A61B5/4041 ,  A61B5/407 ,  A61B17/1637 ,  A61B17/1757 ,  A61B17/320068 ,  A61B17/3423 ,  A61B17/7074 ,  A61B17/708 ,  A61B90/30 ,  A61B90/57 ,  A61B2017/0031420130101 ,  A61B2017/003420130101 ,  A61B2017/0040720130101 ,  A61B2017/0047720130101 ,  A61B2017/0055720130101 ,  A61B2017/0073820130101 ,  A61B2017/0083120130101 ,  A61B2017/0085820130101 ,  A61B2017/0087120130101 ,  A61B2017/32007520170801 ,  A61B2017/344320130101 ,  A61B2017/344720130101 ,  A61B2017/348420130101 ,  A61B2018/0056520130101 ,  A61B2018/0057720130101 ,  A61B2090/03420160201 ,  A61B2090/03620160201 ,  A61B17/56 ,  A61B5/24 ,  A61B2017/348820130101 ,  A61B2017/0094620130101 ,  A61B2034/206820160201 ,  A61B1/00091 ,  A61B1/00094 ,  A61B1/00096 ,  A61B1/00128 ,  A61B1/051 ,  A61B1/126 ,  A61B34/30 ,  A61B2090/30620160201 ,  A61B2090/37120160201 ,  A61B2218/00220130101 ,  A61B2218/00720130101

公开(公告)号：EP3585241B1

公开(公告)日：2024-07-24

申请号：EP18758290.3

申请日：2018-02-21

IPC分类号： A61B1/00 ,  A61B1/05 ,  A61B1/12 ,  A61B17/34 ,  A61B17/56 ,  A61B17/32 ,  A61B17/02 ,  A61B17/00

CPC分类号： A61B17/0293 ,  A61B17/3421 ,  A61B17/3439 ,  A61B2017/0026120130101 ,  A61B2017/026220130101 ,  A61B2017/345420130101 ,  A61B2017/34820130101 ,  A61B2034/205520160201 ,  A61B2090/0802120160201 ,  A61B1/317 ,  A61B17/025 ,  A61B17/1671 ,  A61B17/320016 ,  A61B17/32053 ,  A61B17/7032 ,  A61B90/361 ,  A61B90/50 ,  A61B2017/025620130101 ,  A61B2017/160220130101 ,  A61B2017/344520130101 ,  A61B2090/03720160201 ,  A61B2090/398320160201 ,  A61B1/00103 ,  A61B1/00135 ,  A61B1/00149 ,  A61B1/00154 ,  A61B1/012 ,  A61B1/05 ,  A61B1/3135 ,  A61B5/068 ,  A61B5/4041 ,  A61B5/407 ,  A61B17/1637 ,  A61B17/1757 ,  A61B17/320068 ,  A61B17/3423 ,  A61B17/7074 ,  A61B17/708 ,  A61B90/30 ,  A61B90/57 ,  A61B2017/0031420130101 ,  A61B2017/003420130101 ,  A61B2017/0040720130101 ,  A61B2017/0047720130101 ,  A61B2017/0055720130101 ,  A61B2017/0073820130101 ,  A61B2017/0083120130101 ,  A61B2017/0085820130101 ,  A61B2017/0087120130101 ,  A61B2017/32007520170801 ,  A61B2017/344320130101 ,  A61B2017/344720130101 ,  A61B2017/348420130101 ,  A61B2018/0056520130101 ,  A61B2018/0057720130101 ,  A61B2090/03420160201 ,  A61B2090/03620160201 ,  A61B17/56 ,  A61B5/24 ,  A61B2017/348820130101 ,  A61B2017/0094620130101 ,  A61B2034/206820160201 ,  A61B1/00091 ,  A61B1/00094 ,  A61B1/00096 ,  A61B1/00128 ,  A61B1/051 ,  A61B1/126 ,  A61B34/30 ,  A61B2090/30620160201 ,  A61B2090/37120160201 ,  A61B2218/00220130101 ,  A61B2218/00720130101

公开(公告)号：EP3860424B1

公开(公告)日：2024-07-17

申请号：EP19790977.3

申请日：2019-09-30

IPC分类号： A61B1/00

CPC分类号： A61B1/0005 ,  A61B1/00057 ,  A61B2090/36520160201 ,  A61B2090/30920160201 ,  A61B2090/361420160201 ,  A61B2090/30620160201 ,  A61B90/361 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/0537 ,  A61B5/02007 ,  A61B5/4041 ,  G06V10/141 ,  G06V10/143 ,  G06V10/60 ,  G06V10/56 ,  G06V2201/03120220101 ,  A61B1/000094 ,  A61B1/000096 ,  A61B1/0655 ,  G06V10/761 ,  G06N5/01 ,  G06N7/01 ,  G06F18/22

公开(公告)号：EP3417895A1

公开(公告)日：2018-12-26

申请号：EP18186547.8

申请日：2004-11-17

申请人： Medtronic Ardian Luxembourg S.à.r.l.

发明人： Gelfand, Mark ,  Levin, Howard, R.

IPC分类号： A61M5/172 ,  A61B5/00 ,  A61M5/142 ,  A61B5/20 ,  A61N1/36

CPC分类号： A61M5/14276 ,  A61B5/201 ,  A61B5/4041 ,  A61B5/6852 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2210/1082 ,  A61N1/36017

摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump (105) or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.

公开(公告)号：EP3324833A1

公开(公告)日：2018-05-30

申请号：EP16828491.7

申请日：2016-07-20

申请人： The Board of Trustees of The Leland Stanford Junior University

发明人： LEE, Jin Hyung ,  DUFFY, Ben A.

IPC分类号： A61B5/00 ,  A61B5/0478 ,  A61N1/05 ,  A61N5/06

CPC分类号： A61B5/055 ,  A61B5/0084 ,  A61B5/4041 ,  A61N1/05 ,  A61N1/086 ,  A61N5/0622 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/067

摘要： The present disclosure provides a device for carrying out magnetic resonance imaging compatible optogenetics; and methods for using the device.

公开(公告)号：EP3313278A2

公开(公告)日：2018-05-02

申请号：EP16784559.3

申请日：2016-06-08

申请人： DePuy Synthes Products, Inc.

发明人： CHIEN, Dennis

IPC分类号： A61B5/04

CPC分类号： A61B5/04005 ,  A61B5/0004 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6847 ,  A61B5/6877 ,  A61B5/742

摘要： A neurophysiological monitoring system includes at least one surgical instrument having at least one magnetometer and a control unit configured to receive magnetic field data generated by the at least one magnetometer. The control unit may provide stimulation to a nerve at a known stimulation time and receive magnetic field data from the at least one magnetometer indicative of a response to stimulation of the nerve at a receive time. An interpretation of the magnetic field data based upon the receive time and the stimulation time may be generated.

公开(公告)号：EP2707087B1

公开(公告)日：2018-05-02

申请号：EP12785483.4

申请日：2012-05-11

申请人： Saluda Medical Pty Limited

发明人： PARKER, John Louis ,  LAIRD, James Hamilton ,  KARANTONIS, Dean Michael ,  OBRADOVIC, Milan ,  GORMAN, Robert Bruce

IPC分类号： A61B5/04 ,  A61N1/36 ,  A61B5/00 ,  A61N1/05

CPC分类号： A61N1/36071 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/407 ,  A61B5/4821 ,  A61B5/4824 ,  A61B5/4836 ,  A61N1/0551 ,  A61N1/36139 ,  A61N1/3615

摘要： An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.

公开(公告)号：EP3297519A1

公开(公告)日：2018-03-28

申请号：EP16723816.1

申请日：2016-05-16

申请人： BU Innovations Limited

发明人： HICKISH, Tamash Frederick Gordon ,  DUBEY, Venketesh Nath ,  VAUGHAN, Neil ,  COLE, Jonathan David

IPC分类号： A61B5/00

CPC分类号： A61B5/0051 ,  A61B5/4041 ,  A61B5/4827 ,  A61B5/6898 ,  A61B2560/045

摘要： A device, system and method for vibration sensitivity assessment are provided. The device has an attachment portion configured to detachably connect the device to a programmable vibration source and a probe configured to be applied to a test location on a test subject's skin and to convey vibrations generated by the programmable vibration source to the test location. The programmable vibration source may for example be a mobile telephone. A low-cost and widely usable device for vibration sensitivity assessment is thus provided.

公开(公告)号：EP2348977B1

公开(公告)日：2018-03-28

申请号：EP09748139.4

申请日：2009-09-15

申请人： Med-El Elektromedizinische Geräte GmbH

发明人： STRAHL, Stefan

IPC分类号： A61B5/04 ,  G06K9/00 ,  G06K9/62 ,  A61B5/00 ,  A61N1/05

CPC分类号： A61B5/04001 ,  A61B5/4041 ,  A61N1/0541 ,  G06K9/00523 ,  G06K9/624

摘要： A method is described for processing an electrical stimulation response measurement waveform signal measured in response to delivery of a selected electrical stimulation signal to neural tissue. The electrical stimulation response measurement waveform signal contains a stimulus artifact and one or more neuronal action potentials. The electrical stimulation signal is selected based on satisfying a cost function comparison between at least one stimulus artifact component and a plurality of known neuronal action potential waveforms. The electrical stimulation response waveform signal is then processed using a source separation algorithm to remove the stimulus artifact component.