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公开(公告)号：EP1415187A4
公开(公告)日：2008-03-26
申请号：EP02755606
申请日：2002-08-06
申请人： BIOVIEW LTD
发明人： KAPLAN ERAN , FREIBERGER AVNER
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/244 , G02B21/245 , G02B21/367
摘要： An imaging apparatus with an autofocus mechanism for obtaining focused images. The apparatus comprises: an objective lens, a focus controller (16, 20) for altering a distance between the objective lens and a sample, an object finder (16) for finding objects of interest within the sample, and a light intensity measurement unit (14) which measures light intensity levels of the the identified objects of interest. The focus control alters the sample-objective distance to maximize the light intensity levels being measured, to thereby arrive at a focus position. Objects of interest may be identified by filtering out large objects and optionally by masking out background regions. The apparatus is useful for microscopy and for fluorescent imaging in which light levels are low and noise is high.
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公开(公告)号：EP1684107B1
公开(公告)日：2008-02-27
申请号：EP06001015.4
申请日：2006-01-18
申请人： Olympus Corporation
IPC分类号： G02B21/36
CPC分类号： G02B21/365 , G02B7/08 , G02B21/0012 , G02B21/244
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33.发明公开
公开(公告)号：EP1627344A1
公开(公告)日：2006-02-22
申请号：EP04750306.5
申请日：2004-04-17
申请人： Aperio Technologies
发明人： OLSON, Allen , CRANDALL, Greg , SOENKSEN, Dirk
CPC分类号： G02B21/365 , G02B21/002 , G02B21/244
摘要： Methods and apparatus are provided for computing focus information prior to scanning microscope slides with a line scan camera. The methods include a point-focus procedure that works by moving the slide to the desired measurement location, moving the objective lens through a predefined set of height values, acquiring imagery data at each height, and determining the height of maximum contrast. The methods also include a ribbon-focus procedure whereby imagery data are acquired continuously, while the slide and objective lens are in motion. Both methods may be applied with either a static or a dynamic implementation.
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34.发明授权
公开(公告)号：EP1264205B1
公开(公告)日：2005-12-28
申请号：EP01911762.1
申请日：2001-03-08
申请人： Tibotec BVBA
IPC分类号： G02B21/24
CPC分类号： G02B21/244
摘要： The apparatus for automatically focusing an image in a microscope includes onto an object plane includes an optical system configured to form an optical image of a sample plane to be observed, an autofocusing detection system, and a focus correction system. The autofocusing system includes an autofocusing light beam source for generating autofocusing light beams. The autofocusing system further includes a detection system lens for directing autofocusing light beams to an autofocusing detection device, and an autofocusing detection device for determining the amount of displacement of the image of the object plane from a desired focused reference plane. The focusing correction system includes a feedback controller and focus adjusting device for automatically adjusting the distance between an objective lens and the sample plane in order to properly focus the image in the optical system. A related method of automatically focusing an image of an object plane in a microscope.
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35.发明公开
公开(公告)号：EP1300713A3
公开(公告)日：2004-11-03
申请号：EP02028849.4
申请日：1996-11-27
IPC分类号： G01N15/14
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space (290). The color space converted image is then low pass filtered (292) and compared to a threshold (294) to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed (296) to group candidate object of interest pixels together into groups which are compared to blob parameters (298) to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.
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公开(公告)号：EP1373957A2
公开(公告)日：2004-01-02
申请号：EP02722408.8
申请日：2002-04-08
申请人： Renishaw plc
IPC分类号： G02B7/36
CPC分类号： G02B7/36 , G02B21/244
摘要： The invention relates to a method and apparatus for focusing structured image such as a laser spot. A method for determining the degree of focus of such a structured image is disclosed whereby: an image is provided at a photosensitive array formed from a plurality of elements; the position of the image is determined; for an element of the array a weighting is assigned according to the position of that element relative to the position of the image; the intensity of the image at the element is determined; a value is produced for the element dependent on its weighting and the intensity of the image thereat. In addition the values of the plurality of elements are summed and one overall focus value is found which is indicative of the degree of focus of the image. This value is used to search for and maintain best focus and methods for achieving this are disclosed also. Apparatus is shown in which a microprocessor and a controller are used to perform the methods disclosed.
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公开(公告)号：EP1285300A2
公开(公告)日：2003-02-26
申请号：EP01939556.5
申请日：2001-05-24
IPC分类号： G02B21/24
CPC分类号： G02B21/244
摘要： The invention relates to reverse focusing and methods and systems which employ reverse focusing. In a particular example, an automated focusing microscope uses one or more reverse focusing steps to acquire a focused image. Computer programs having instructions for instructing a computer to acquire a focused image by reverse focusing are also included.
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38.发明公开IMAGE CONTENT AUTOFOCUS FOR MICROSCOPY USING A NOISE-INSENSITIVE FOCUS FILTER 审中-公开AUTOFOKUSSIERENG图像内容进行观察使用抗噪声不敏感的聚焦滤波器
公开(公告)号：EP1040379A1
公开(公告)日：2000-10-04
申请号：EP98963731.9
申请日：1998-12-18
申请人： Cellavision AB
CPC分类号： G06T3/0075 , G02B21/244 , G06T3/403
摘要： An autofocusing system in which optimal or nearly optimal linear filters are selected for filtering an image signal so that the components of the image signal which contain image content, and thus, focus information are amplified while the components of the image signal which contain noise are damped. One set of nearly optimal linear filters are modified second order difference filters in which the number of internal zeros are modified to tune the filter to the particular equipment.
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公开(公告)号：EP0834758B1
公开(公告)日：1999-09-01
申请号：EP97120924.2
申请日：1995-06-30
申请人： Price, Jeffrey H.
发明人： Price, Jeffrey H.
CPC分类号： G02B21/244 , G01N15/147 , G01N21/6458 , G02B21/002
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40.发明公开
公开(公告)号：EP0195754A3
公开(公告)日：1989-07-19
申请号：EP86830066.6
申请日：1986-03-19
CPC分类号： G02B21/244
摘要： An improved apparatus for the automatic focusing of a lens system comprising a space dissector (17) for analysing the space frequency components of the image close to the ideal focus plane, having devices (53, 57) for detecting the plane, and the position of this plane, comprising the maximum of space frequencies close to the ideal focus plane. An electronical device is provided for obtaining suitable signal from said space dissector (17) to provide an adjustement control signal actuating a servo-control unit controlling the lens focusing for leading the image plane comprising the maximum of high frequency components in coincidence with said ideal focus plane.
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