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    Pharmaceutical and dietary compositions for the treatment and prophylaxis of metabolic disturbances in infants containing vitamin B6, folic acid and vitamin B12
    33.
    发明公开
    Pharmaceutical and dietary compositions for the treatment and prophylaxis of metabolic disturbances in infants containing vitamin B6, folic acid and vitamin B12 失效
    药物以及含有维生素B6，叶酸和维生素B12为婴儿代谢性疾病的治疗营养制剂。

    公开(公告)号：EP0595006A1

    公开(公告)日：1994-05-04

    申请号：EP93114765.6

    申请日：1993-09-14

    申请人： VESTA MEDICINES (PROPRIETARY) LIMITED

    发明人： Serfontein, Willem Jacob

    IPC分类号： A61K31/68

    CPC分类号： A61K31/714 ,  A23L33/155 ,  A61K31/505 ,  A61K31/44 ,  A61K2300/00

    摘要： Pharmaceutical respectively dietary preparations are disclosed for the treatment or prophylaxis of elevated homocysteine and/or methionine levels in the blood of human infants and pathological disturbances connected therewith, said preparation comprising in combination:-

    a) vitamin B 6 as such or in the form of a pharmaceutically acceptable acid salt, at least in part in the form of pyridoxal (PL) or a compound which in vivo readily releases PL without the intervention of oxidase enzyme or oxygen.
    b) folate or a precursor of folate which releases folate in vivo, and
    c) vitamin B12, with or without intrinsic factor, in the following ratios:-
    a) : b) from 1:25 to 10 000 : 1
    b) : c) from 1:1 to 50 000 : 1
    The preparations are to be incorporated in infant bottle feed mixes.

    摘要翻译： 药物分别膳食制剂盘游离缺失于与连接有人类婴儿和病理干扰的血液治疗或升高的高半胱氨酸和/或甲硫氨酸水平的预防，该制剂包括以下的组合： - 一）维生素B 6作为搜索或在形式 药学上可接受的酸的盐，至少在吡哆醛（PL）或在体内容易释放PL没有氧化酶或氧的介入的化合物的一部分。 b）中的叶酸或叶酸的前体，其在体内释放叶酸盐，和c）维生素B12，含有或不含固有因子，以以下比率： - A）:B）从1:25至10,000：1 :B）:C ）从1：1至50,000：1的制剂是在婴儿瓶进料混合物被引入。

    Production of vitamin B12 employing a fused cell hybrid
    38.
    发明公开
    Production of vitamin B12 employing a fused cell hybrid 失效
    生产维生素B12使用融合细胞杂交

    公开(公告)号：EP0131456A3

    公开(公告)日：1986-07-23

    申请号：EP84304653

    申请日：1984-07-06

    申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

    发明人： Takeuchi, Daizou ,  Hamada, Masahiro

    IPC分类号： C12N15/00 ,  C12P19/42 ,  C12N01/20 ,  A61K31/68

    CPC分类号： C12N15/03 ,  C12P19/42

    摘要： A fused cell hybrid is obtained by fusing a cell of a chlorophyll-producing bacterial species belonging to the photosynthetic genus Rhodopseudomonas, such as Rhodo- pseudomonasspheroides, with a cell of a vitamin B 12 - producing bacterial species belonging to the methanol-metabolising genus Protaminobacter, such as Protaminobacter ruber. The fused cell hybrid is cultured to produce vitamin B 12 .

    摘要翻译： 通过将属于红假单胞菌的光合性红假单胞菌（Rhodopseudomonas），例如红假单胞菌属（Rhodopseudomonas spheroides））的产生细胞的细胞的细胞与属于甲醇代谢类Protaminobacter的维生素B12产生菌的细胞融合，获得融合细胞杂交体， 作为Protaminobacter ruber。 培养融合的细胞杂交体以产生维生素B12。

    Production of vitamin B12 employing a fused cell hybrid
    39.
    发明公开
    Production of vitamin B12 employing a fused cell hybrid 失效
    Herstellung von维生素B12 durch Verwendung eines fusionierten Zellhybrids。

    公开(公告)号：EP0131456A2

    公开(公告)日：1985-01-16

    申请号：EP84304653.3

    申请日：1984-07-06

    申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

    发明人： Takeuchi, Daizou ,  Hamada, Masahiro

    IPC分类号： C12N15/00 ,  C12P19/42 ,  C12N1/20 ,  A61K31/68

    CPC分类号： C12N15/03 ,  C12P19/42

    摘要： A fused cell hybrid is obtained by fusing a cell of a chlorophyll-producing bacterial species belonging to the photosynthetic genus Rhodopseudomonas, such as Rhodo- pseudomonasspheroides, with a cell of a vitamin B 12 - producing bacterial species belonging to the methanol-metabolising genus Protaminobacter, such as Protaminobacter ruber. The fused cell hybrid is cultured to produce vitamin B 12 .

    摘要翻译： 通过将属于红假单胞菌的光合性红假单胞菌（Rhodopseudomonas），例如红假单胞菌属（Rhodopseudomonas spheroides））的产生细胞的细胞的细胞与属于甲醇代谢类Protaminobacter的维生素B12产生菌的细胞融合，获得融合细胞杂交体， 作为Protaminobacter ruber。 培养融合的细胞杂交体以产生维生素B12。

    Composition for the treatment of hemorrhoids by oral administration
    40.
    发明公开
    Composition for the treatment of hemorrhoids by oral administration 失效
    组成由口服治疗痔疮。

    公开(公告)号：EP0035058A1

    公开(公告)日：1981-09-09

    申请号：EP80107471.7

    申请日：1980-11-29

    申请人： Breskman, Joseph S.

    发明人： Breskman, Joseph S.

    IPC分类号： A61K31/68

    CPC分类号： A61K31/714 ,  Y10S514/882

    摘要： A composition and a method for treatment of hemorrhoids are disclosed. The composition comprises a combination of thiamin, riboflavin, pyridoxine, cobalamin, niacinamide, and pantothenic acid, preferably in liquid form. In preferred embodiments, the composition may also contain whole liver and/or yeast or their extracts. The method comprises oral administration of the composition to a person suffering from hemorrhoids.