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    Process for production of hydroxocobalamin
    5.
    发明公开
    Process for production of hydroxocobalamin 失效
    Verfahren zur Herstellung von Hydroxocobalamin。

    公开(公告)号：EP0533115A1

    公开(公告)日：1993-03-24

    申请号：EP92115778.0

    申请日：1992-09-16

    申请人： NIPPON OIL CO. LTD.

    发明人： Hirayama, Takayuki ,  Kiyota, Takashi

    IPC分类号： C07H23/00 ,  A61K31/68

    CPC分类号： C07H23/00

    摘要： A process for the production of hydroxocobalamin comprising the steps of:

    (1) putting a solution containing Co-enzyme type vitamin B₁₂ contact with a divinylbenzene/styrene copolymer resin so that the Co-enzyme type vitamin B₁₂ is adsorbed in the resin;
    (2) washing the resin with purified water or aqueous washing solution at a temperature between 30°C and 70°C so as to remove purities;
    (3) extracting the Co-enzyme type vitamin B₁₂ adsorbed on the resin with an aqueous solution containing at least 25% by of a lower alcohol, so as to obtain an elute containing Co-enzyme type vitamin B₁₂;
    (4) irradiating the elute with a light so as to convert Co-enzyme type vitamin B₁₂ to hydroxocobalamin; and
    (5) treating the hydroxocobalamin-containing solution from step (4) with an inorganic adsorbent and recovering the hydroxocobalamin.

    摘要翻译： 一种生产羟钴胺素的方法，包括以下步骤：（1）将含有辅酶型维生素B12的溶液与二乙烯基苯/苯乙烯共聚物树脂接触，使得辅酶型维生素B12吸附在树脂中; （2）在30℃〜70℃的温度下，用纯水或水洗涤液洗涤树脂，以除去纯度; （3）用含有至少25％的低级醇的水溶液提取吸附在树脂上的辅酶型维生素B12，以获得含有辅酶型维生素B12的洗脱液; （4）用光照射洗脱液，以将辅酶型维生素B12转化为羟钴胺素; 和（5）用无机吸附剂处理来自步骤（4）的含有羟钴胺素的溶液并回收羟钴胺素。

    Oral delivery system
    8.
    发明公开
    Oral delivery system 失效
    Orales Lieferungsystem。

    公开(公告)号：EP0220030A2

    公开(公告)日：1987-04-29

    申请号：EP86307849.9

    申请日：1986-10-10

    申请人： BIOTECHNOLOGY AUSTRALIA PTY. LTD.

    发明人： Russell-Jones, Gregory John ,  De Aizpurua, Henry James ,  Howe, Peter Allan ,  Burge, Geoffery Lewis

    IPC分类号： A61K47/00 ,  A61K31/68

    CPC分类号： A61K39/00 ,  A61K39/385 ,  A61K47/54 ,  A61K2039/60

    摘要： The present invention provides a complex of a drug, hormone, bio-active peptide, or immunoger with the carrier molecule vitamin B12 and a method for delivering said complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby elicit a pharmacological response to the drug, hormone, or bio- active molecule orto elicit a systemic immune response to the immunogen. The invention also provides a method for the production of the complex. Further the invention provides medicaments containing the complex.

    摘要翻译： 本发明提供药物，激素，生物活性肽或免疫原与载体分子维生素B12的复合物，以及用于将所述复合物递送至宿主脊椎动物的肠的方法，以将复合物递送至 从而引起对药物，激素或生物活性分子的药理学反应或引发对免疫原的全身免疫应答。 本发明还提供了一种生产复合物的方法。 此外，本发明提供了含有该复合物的药物。