公开(公告)号：EP1846416A4

公开(公告)日：2009-07-01

申请号：EP06719228

申请日：2006-01-24

申请人： GLAXO GROUP LTD

发明人： MILLER WILLIAM HENRY ,  ROUSE MEAGAN B ,  SEEFELD MARK ANDREW

IPC分类号： C07D497/04 ,  A61K31/5383 ,  A61K31/542 ,  A61P31/04 ,  C07D498/04

CPC分类号： C07D519/00

公开(公告)号：EP1796467A4

公开(公告)日：2009-07-01

申请号：EP05800794

申请日：2005-09-23

申请人： JANSSEN PHARMACEUTICA NV

发明人： LIU JIAN ,  PATCH RAYMOND J ,  PLAYER MARK R

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/495 ,  A61K31/50 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00

CPC分类号： C07D487/04

公开(公告)号：EP1004586B1

公开(公告)日：2009-07-01

申请号：EP99117275.0

申请日：1995-05-19

申请人： ISHIHARA SANGYO KAISHA, LTD. ,  Daiichi Sankyo Company, Limited

发明人： Hayashi, Koji ,  Tokumoto, Sho ,  Yoshizawa, Hiroshi ,  Isogai, Tatsuo ,  Kimura, Masaru ,  Sawaki, Masahiko ,  Ando, Takayoshi ,  Katsuyama, Isamu ,  Ariyoshi, Hayato ,  Nakamura, Tadashi

IPC分类号： C07D497/20 ,  A61K31/435

CPC分类号： C07D497/20

公开(公告)号：EP2040712A2

公开(公告)日：2009-04-01

申请号：EP07799643.7

申请日：2007-07-17

申请人： Anadys Pharmaceuticals, Inc.

发明人： HALEY, Gregory, J. ,  LENNOX, Joseph, R. ,  XIANG, Alan, Xin ,  WEBBER, Stephen, E.

IPC分类号： A61K31/519 ,  A61K31/7068 ,  A61P31/12 ,  A61P35/00 ,  C07D497/04 ,  C07H19/24

CPC分类号： C07H19/24 ,  C07D513/04

摘要： The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-J]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.

公开(公告)号：EP2010532A1

公开(公告)日：2009-01-07

申请号：EP07728534.4

申请日：2007-04-25

申请人： Glaxo Group Limited

发明人： BROOKS, Gerald ,  GIORDANO, Ilaria ,  HENNESSY, Alan, Joseph ,  PEARSON, Neil, David

IPC分类号： C07D471/16 ,  A61K31/4375 ,  A61P31/00 ,  C07D491/04 ,  C07D495/04 ,  C07D497/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D471/16 ,  C07D519/00

摘要： Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

公开(公告)号：EP1688418A3

公开(公告)日：2008-05-14

申请号：EP06004401.3

申请日：2002-11-13

申请人： MILLENNIUM PHARMACEUTICALS, INC. ,  KYOWA HAKKO KOGYO CO., LTD.

发明人： Luly, Jay R. ,  Nakasato, Yoshisuke ,  Ohshima, Etsuo ,  Harriman, Geraldine C. B. ,  Carson, Kenneth G. ,  Ghosh, Shomir ,  Elder, Amy M. ,  Mattia, Karen M.

IPC分类号： C07D491/04 ,  C07D497/04 ,  C07D223/20 ,  C07D313/12 ,  C07D337/12 ,  A61P1/00 ,  A61K31/4353 ,  A61K31/55 ,  C07D313/00 ,  C07D221/00 ,  C07D471/04 ,  C07D223/00 ,  C07D519/00 ,  C07D491/00 ,  C07D513/04 ,  C07D337/00 ,  C07D451/00

CPC分类号： C07D491/04 ,  C07D211/46

摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.

公开(公告)号：EP1756119B1

公开(公告)日：2007-10-10

申请号：EP05778643.6

申请日：2005-06-15

申请人： Centre National de la Recherche Scientifique ,  Université Louis Pasteur de Strasbourg

发明人： HIBERT, Marcel, François, Louis ,  FRANCHET, Christel, Anne ,  GALZI, Jean-Luc ,  PATTUS, Franc, Emile, Jean ,  GUILLIER, Fabrice, Yves

IPC分类号： C07D497/10 ,  C07D295/14 ,  C07D277/40 ,  C07D241/26 ,  C07D213/56 ,  C07D207/16

CPC分类号： C07D497/10 ,  Y02P20/55

摘要： The invention concerns the use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R'1 represent in particular a hydrogen atom; R2 represents an amino acid side chain or an amino acid derivative; R3 represents a group derived from a carboxylic acid, bearing a basic entity; R4 represents in particular an alkyl group containing 1 to 10 carbon atoms; and A represents a hydrogen atom, a protecting group or a tracing group, in particular a fluorophor, a colouring agent or a quencher, for determining, through binding studies, ligands of receptors whose ligand is unknown or whose ligand useful for carrying out specific affinity binding assays is unknown.

摘要翻译： 本发明涉及一组通式（I）化合物的用途，其中：n是0或1; p表示1和6之间的整数; r代表1和12之间的整数; R1和R1'特别代表氢原子; R2代表氨基酸侧链或氨基酸衍生物; R3代表衍生自具有碱性实体的羧酸的基团; R4特别表示含有1至10个碳原子的烷基; A代表氢原子，保护基团或示踪基团，特别是荧光团，着色剂或猝灭剂，用于通过结合研究确定配体未知或其配体可用于进行特异性亲和力的受体的配体 结合分析未知。

公开(公告)号：EP1836203A2

公开(公告)日：2007-09-26

申请号：EP06718423.4

申请日：2006-01-13

申请人： NEUROGEN CORPORATION

发明人： CALDWELL, Timothy M. ,  CHENARD, Bertrand ,  HODGETTS, Kevin

IPC分类号： C07D471/02 ,  C07D215/38 ,  C07D215/44 ,  C07D401/00 ,  C07D403/00 ,  C07D409/00 ,  C07D239/02 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00 ,  A01N43/58 ,  A01N43/60 ,  A01N43/54 ,  A01N43/42 ,  A61K31/50 ,  A61K31/45 ,  A61K31/501 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D471/04 ,  C07D417/14

摘要： Heteroaryl substituted quinolin-4-ylamine analogues of Formula (I) are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

公开(公告)号：EP1805150A2

公开(公告)日：2007-07-11

申请号：EP05824707.3

申请日：2005-10-26

申请人： Third-Order Nanotechnologies, Inc.

发明人： GOETZ, Frederick J. ,  GOETZ, Frederick J., Jr.

IPC分类号： C07D241/36 ,  C07D487/00 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00 ,  C08G59/00

CPC分类号： G02B1/04 ,  C07D487/04 ,  C07D487/14 ,  C09B57/00 ,  G02F1/3612

摘要： NLO chromophores of the form of Formula I and the commercially acceptable salts, solvates and hydrates thereof, wherein Z1-4, XI-4,π1-2, D and A have the definitions provided herein.

公开(公告)号：EP1797101A1

公开(公告)日：2007-06-20

申请号：EP05788709.3

申请日：2005-08-08

申请人： Matrix Laboratories Limited

发明人： CHAVA, Satyanaryana, Plot No 40 ,  GORANTLA, Seeta Ramanjaneyulu, Plot No-12 ,  GOGULAPATHI, Venkata Panakala Rao

IPC分类号： C07D497/06

CPC分类号： C07D498/06

摘要： The present invention relates to an improved process for the preparation of Levofloxacin hemihydrate by adjusting the moisture content of the solvent to about 12% to about 20% during crystallization.