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    COLLECTIONS DE COMPOSES TRACABLES ET LEURS UTILISATIONS
    3.
    发明授权
    COLLECTIONS DE COMPOSES TRACABLES ET LEURS UTILISATIONS 有权
    收藏品的合成与追溯

    公开(公告)号：EP1756119B1

    公开(公告)日：2007-10-10

    申请号：EP05778643.6

    申请日：2005-06-15

    申请人： Centre National de la Recherche Scientifique ,  Université Louis Pasteur de Strasbourg

    发明人： HIBERT, Marcel, François, Louis ,  FRANCHET, Christel, Anne ,  GALZI, Jean-Luc ,  PATTUS, Franc, Emile, Jean ,  GUILLIER, Fabrice, Yves

    IPC分类号： C07D497/10 ,  C07D295/14 ,  C07D277/40 ,  C07D241/26 ,  C07D213/56 ,  C07D207/16

    CPC分类号： C07D497/10 ,  Y02P20/55

    摘要： The invention concerns the use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R'1 represent in particular a hydrogen atom; R2 represents an amino acid side chain or an amino acid derivative; R3 represents a group derived from a carboxylic acid, bearing a basic entity; R4 represents in particular an alkyl group containing 1 to 10 carbon atoms; and A represents a hydrogen atom, a protecting group or a tracing group, in particular a fluorophor, a colouring agent or a quencher, for determining, through binding studies, ligands of receptors whose ligand is unknown or whose ligand useful for carrying out specific affinity binding assays is unknown.

    摘要翻译： 本发明涉及一组通式（I）化合物的用途，其中：n是0或1; p表示1和6之间的整数; r代表1和12之间的整数; R1和R1'特别代表氢原子; R2代表氨基酸侧链或氨基酸衍生物; R3代表衍生自具有碱性实体的羧酸的基团; R4特别表示含有1至10个碳原子的烷基; A代表氢原子，保护基团或示踪基团，特别是荧光团，着色剂或猝灭剂，用于通过结合研究确定配体未知或其配体可用于进行特异性亲和力的受体的配体 结合分析未知。

    PROCEDE D'IDENTIFICATION D'EFFECTEURS ALLOSTERIQUES D'UN RECEPTEUR
    7.
    发明公开
    PROCEDE D'IDENTIFICATION D'EFFECTEURS ALLOSTERIQUES D'UN RECEPTEUR 有权
    检测方法的一个受体的变构效应的

    公开(公告)号：EP1514112A2

    公开(公告)日：2005-03-16

    申请号：EP03748170.2

    申请日：2003-06-16

    申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE LOUIS PASTEUR DE STRASBOURG

    发明人： GALZI, Jean-Luc ,  HIBERT, Marcel ,  BOURGUIGNON, Jean-Jacques ,  MAILLET, Emeline

    IPC分类号： G01N33/557 ,  G01N33/542 ,  G01N33/566 ,  C07C229/14

    CPC分类号： G01N33/566 ,  C07K5/06086 ,  G01N33/542 ,  G01N33/557

    摘要： The invention concerns a method for isolating an allosteric effector of a receptor, by determining the variation of the dissociation kinetics of the complex formed between said receptor and one of its ligands in the presence of said allosteric effector, as compared to the kinetics dissociation formed between said receptor and said ligand, in the absence of said effector, and/or the amplitude of the linkage formed between said receptor and one of its ligands in the presence of said allosteric effector, as compared to the amplitude of the linkage formed between said receptor and said ligand in the absence of said effector, said receptor and said ligand being involved in at least one biological response in suitable physiological conditions, and the allosteric effector being capable of modulating at least one of the responses, said receptor being marked by at least one fluorescent protein, said ligand being marked by a marker consisting either of a molecule capable of absorbing light emitted by the fluorescent protein, or by a fluorescent substance, said steps for determining kinetics dissociation variation and amplitude variation being carried out by fluorescence energy transfer.

    PROCEDE D'IDENTIFICATION D'EFFECTEURS ALLOSTERIQUES D'UN RECEPTEUR
    10.
    发明授权
    PROCEDE D'IDENTIFICATION D'EFFECTEURS ALLOSTERIQUES D'UN RECEPTEUR 有权
    检测方法的一个受体的变构效应的

    公开(公告)号：EP1514112B1

    公开(公告)日：2006-09-06

    申请号：EP03748170.2

    申请日：2003-06-16

    申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE LOUIS PASTEUR DE STRASBOURG

    发明人： GALZI, Jean-Luc ,  HIBERT, Marcel ,  BOURGUIGNON, Jean-Jacques ,  MAILLET, Emeline

    IPC分类号： G01N33/557 ,  G01N33/542 ,  G01N33/566 ,  C07C229/14

    CPC分类号： G01N33/566 ,  C07K5/06086 ,  G01N33/542 ,  G01N33/557

    摘要： The invention concerns a method for isolating an allosteric effector of a receptor, by determining the variation of the dissociation kinetics of the complex formed between said receptor and one of its ligands in the presence of said allosteric effector, as compared to the kinetics dissociation formed between said receptor and said ligand, in the absence of said effector, and/or the amplitude of the linkage formed between said receptor and one of its ligands in the presence of said allosteric effector, as compared to the amplitude of the linkage formed between said receptor and said ligand in the absence of said effector, said receptor and said ligand being involved in at least one biological response in suitable physiological conditions, and the allosteric effector being capable of modulating at least one of the responses, said receptor being marked by at least one fluorescent protein, said ligand being marked by a marker consisting either of a molecule capable of absorbing light emitted by the fluorescent protein, or by a fluorescent substance, said steps for determining kinetics dissociation variation and amplitude variation being carried out by fluorescence energy transfer.