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公开(公告)号：EP1236471A2
公开(公告)日：2002-09-04
申请号：EP02009993.3
申请日：1992-11-23
IPC分类号： A61K31/565 , A61K31/57 , A61K31/56 , C07J3/00 , C07J5/00 , C07J9/00 , C07J11/00 , C07J41/00 , C07J51/00
CPC分类号： A61K31/573 , A61K31/56 , A61K31/565 , A61K31/569 , A61K31/57 , A61K31/58 , A61K31/665 , C07J3/00 , C07J5/0053 , C07J9/00 , C07J11/00 , C07J41/0005 , C07J41/0027 , C07J51/00 , A61K2300/00
摘要： Angiostatic steroids for use in controlling neovascularization and ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating neovascularization and ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated intraocular pressure during the treatment of inflammation is disclosed.
摘要翻译： 公开了用于控制新生血管形成和高眼压症的止血类固醇。 公开了血管抑制类固醇的药物组合物及其用于治疗新生血管形成和高眼压症的方法，包括控制与原发性开角型青光眼相关的眼压高血压。 此外，公开了在治疗炎症期间化合物与糖皮质激素的组合以防止升高的眼内压。
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公开(公告)号：EP1087988A1
公开(公告)日：2001-04-04
申请号：EP99927728.8
申请日：1999-06-18
申请人： NOVO NORDISK A/S
发明人： MURRAY, Anthony , FAARUP, Peter
IPC分类号： C07J9/00 , C07J11/00 , A61K31/575
CPC分类号： A61K31/575
摘要： Certain novel sterol derivatives having no hydroxy group in the 3 position can be used to regulate the meiosis in oocytes and in male germ cells.
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公开(公告)号：EP0682672A1
公开(公告)日：1995-11-22
申请号：EP94906918.0
申请日：1994-02-04
申请人： Akzo Nobel N.V.
发明人： LOOZEN, Hubert, Jan, Jozef , SCHOT, Lodewijk, Pieter, Cornelis , VAN DE WERF-PIETERS, Jane, Margretha, Lena
CPC分类号： A61K31/565 , C07J1/0096 , C07J11/00 , C07J21/008 , C07J33/007 , C07J41/0044 , C07J41/0094 , C07J51/00
摘要： A use of a steroid having general formula (I), wherein R1 represents O, (H, OH), or two hydrogen atoms; R2 is hydroxy, optionally etherified or esterified; R3 is (2-6 C) alkynyl, optionally substituted with hydroxy; R4 is CN or one of the hydrocarbon groups selected from (1-6 C) alkyl, (1-6 C) alkoxy, (2-6 C) alkenyl, (2-6 C) alkynyl, and (2-6 C) alkylidene, each of said hydrocarbon groups may optionally be substituted with halogen, hydroxy or (1-6 C) alkoxy; and R5 is hydrogen or (1-6 C) alkyl, for the manufacture of a medicament for the treatment or prevention of menopausal complaints, especially osteoporosis.
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公开(公告)号：EP0669931A1
公开(公告)日：1995-09-06
申请号：EP94902304.0
申请日：1993-11-18
发明人： WEBB, Robert, Lee
IPC分类号： A61K31 , A61K45 , A61P35 , C07J3 , C07J7 , C07J9 , C07J11 , C07J15 , C07J31 , C07J41 , C07J61 , C07J73 , C07J75
CPC分类号： C07J73/005 , A61K31/575 , A61K31/58 , A61K31/585 , A61K45/06 , C07J41/0038 , C07J41/0072 , A61K31/505 , A61K2300/00
摘要： Invented are novel 17α-acyl steroidal 5α-reductase inhibiting compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-α-reductase. Also invented are novel processes used in preparing these compounds.
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35.发明授权
公开(公告)号：EP0510167B1
公开(公告)日：1995-08-23
申请号：EP92900237.6
申请日：1991-11-12
发明人： LANQUETIN, Michel
CPC分类号： C07J7/0045 , C07J1/0025 , C07J1/0074 , C07J1/0077 , C07J5/0053 , C07J11/00
摘要： A novel method is provided for crystallizing organic and particularly steroidal substances. In particular, a crystallization method is provided whereby a predeterminable and homogenous particle size class can be obtained non-mechanically, and wherein a substance is dissolved in a ternary mixture consisting of a lipophilic solvent, a hydrophilic solvent and a surface-active agent at a temperature close to boiling, whereafter the mixture is allowed to cool to a temperature at which crystallization is initiated and the crystals thereby formed are separated. The method can be used for producing pharmaceutical active principles.
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36.发明公开Steroids useful as anti-cancer and anti-obesity agents, a therapeutic composition containing them and use thereof for the preparation of a therapeutic composition 失效类固醇用作抗癌和肥胖，含有它以及它们用于治疗性组合物的制备中使用的治疗组合物。
公开(公告)号：EP0246650A1
公开(公告)日：1987-11-25
申请号：EP87107411.8
申请日：1987-05-21
IPC分类号： C07J11/00 , C07J1/00 , A61K31/565
CPC分类号： C07J51/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J11/00 , C07J13/005 , C07J21/008 , C07J41/0005 , C07J41/0016 , C07J41/005 , C07J53/004
摘要： A compound of the formula:
useful as cancer preventive agent, anti-obesity agent, anti-hyperglycemic agent, anti-aging agent and anti-hypercholesterolemic agent and useful in combatting coronary diseases and autoimmune diseases.
Encompassed is also a therapeutic composition containing an effective amount of a compound of formula IA, and the use of a compound of formula IA for the preparation of a therapeutic composition.摘要翻译： 式的化合物：
癌症预防剂，抗肥胖剂，抗高血糖剂，抗老化剂和抗高胆固醇血症剂在打击冠状动脉疾病和自身免疫疾病的有用的和。 涵盖的是在由此有效量的式IA的化合物的含有治疗组合物，以及用于治疗性组合物的制备中的用途式IA的化合物。 -
公开(公告)号：EP0040517A3
公开(公告)日：1983-09-07
申请号：EP81302154
申请日：1981-05-14
发明人： Mori, Kenji
CPC分类号： A01N49/00 , C07J9/00 , C07J11/00 , C07J31/006 , C07J53/00 , C07J73/003
摘要： Homobrassinolide of the formula:
which shows a plant growth promoting activity.-
公开(公告)号：EP0040517A2
公开(公告)日：1981-11-25
申请号：EP81302154.0
申请日：1981-05-14
发明人： Mori, Kenji
CPC分类号： A01N49/00 , C07J9/00 , C07J11/00 , C07J31/006 , C07J53/00 , C07J73/003
摘要： Homobrassinolide of the formula:
which shows a plant growth promoting activity.-
39.发明公开3-Desoxy-delta-15-Steroide, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate 失效3-脱氧Δ-15类固醇，它们的制备方法和含有它们的药物组合物的过程。
公开(公告)号：EP0034114A1
公开(公告)日：1981-08-19
申请号：EP81730010.6
申请日：1981-02-02
发明人： Hofmeister, Helmut, Dr. , Wiechert, Rudolf, Prof.Dr. , Annen, Klaus, Dr. , Laurent, Henry, Dr. , Beier, Sybille, Dr.
IPC分类号： C07J11/00 , A61K31/565
CPC分类号： C07J11/00 , C07J17/00 , C07J33/007
摘要： 3-Desoxy-Δ 15 -Steroide der allgemeinen Formel I
worin
R 1 ein Wasserstoffatom oder eine Acylgruppe und
R 2 eine Ethinyl-, Chlorethinyl- oder Propinylgruppe bedeuten.
Die neuen 3-Desoxy-Δ 15 -Steroide sind durch eine starke gestagene Wirkung ausgezeichnet und haben nur eine sehr geringe androgene Nebenwirkung.摘要翻译： 3-脱氧△'通式<5>类固醇I
其中，R是氢原子或酰基且R 2代表乙炔基，氯乙炔基或丙炔基。 新的3-脱氧△'<5>类固醇的特征是强烈的促孕效应和具有非常低的雄激素副作用。 -
公开(公告)号：EP3830103B1
公开(公告)日：2023-11-08
申请号：EP19748933.9
申请日：2019-07-30
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