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31.发明授权
公开(公告)号：EP3487481B1
公开(公告)日：2024-02-21
申请号：EP17749616.3
申请日：2017-07-18
IPC分类号： A61K9/08 , A61K47/36 , A61K31/196 , A61K31/58 , A61K31/407 , A61K31/5415 , A61K47/69 , A61P19/02 , C08B37/16 , C08L5/16
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公开(公告)号：EP4317206A1
公开(公告)日：2024-02-07
申请号：EP21932636.0
申请日：2021-11-01
发明人： SHEN, Zheyu , LU, Yudie
摘要： A gadolinium chelate, a preparation method therefor, and an application thereof. The gadolinium chelate is a complex formed by chelation of gadolinium ions and macromolecules. The macromolecules comprise any one of or a copolymer or mixture of two or more of carboxylic acid-containing high-molecular polymers, amino-containing high-molecular polymers, hydroxyl-containing high-molecular polymers, polyester high-molecular polymers, polyether high-molecular polymers, polyamide high-molecular polymers, proteins, polypeptides, and polysaccharides. The gadolinium ions and the macromolecules form the gadolinium chelate by means of chelation. The gadolinium chelate is a water-soluble macromolecular drug, can improve a longitudinal relaxation rate r 1 and reduce a ratio of r 2 /r 1 , has good water-solubility and high stability, and meanwhile, can exhibit a good imaging effect in a short period of time and shorten an MRI time.
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公开(公告)号：EP4311835A1
公开(公告)日：2024-01-31
申请号：EP23178829.0
申请日：2023-06-13
发明人： He, Qiming , Huang, Jin , Li, Yuzhu , Wang, Huihui , Liu, Ke , Du, Chuting , Wu, Dan , Ma, Baopeng , Ren, Dan , Xie, Xingwei , Song, Shiyun , Wu, Shuaiqiang , Wang, Yuping , Chen, Guangjing
摘要： This invention belongs to the technical field of plant extract separation, and specifically relates to a pollen polysaccharide 1-4 and its separation method and application. This invention extracts, separates and purifies the polysaccharide from oilseed rape pollen to obtain pollen polysaccharide 1-4, which have been tested to be effective in the direction of plant growth-promoting and stress resistance. At the same time, the invention also finds that the pollen polysaccharide active moiety Fr, the pollen polysaccharide active moiety Fr-1 and the pollen polysaccharide active moiety Fr-1-5 of the crude isolated component of rape pollen also have plant growth-promoting and stress-resistant effects.
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公开(公告)号：EP4306550A1
公开(公告)日：2024-01-17
申请号：EP22184569.6
申请日：2022-07-13
申请人： Adocia
摘要： The invention concerns cross-linked dextran polymer Dx bearing anionic groups wherein the at least divalent radical L(-)i is covalently bound to the dextran polymer backbone with i -W- radicals, wherein,
- L(-) i is a linear or branched polyether
- i is the valence of L and the number of -W- radicals bound to the dextran polymer and is an integer comprised from 2 to 8 (2 ≤ i ≤ 8),
- -W- is a radical comprising at least a radical alkyl linear or branched and optionally comprising heteroatoms such as oxygen, nitrogen or sulfur, aromatic cycles, polyether derivatives and that does not comprise two or more alpha aminoacid residues in particular linked by peptidic bond(s).
It also concerns the dextran polymers before the crosslinking reaction and the process to synthetize a cross-linked dextran polymer according to the invention, into the form of a hydrogel.
It also concerns a hydrogel comprising the crosslinked dextran polymer of the invention and/or a hydrogel that further comprises biological cells.
It also concerns therapeutic use of the hydrogel according to the invention for treating a disorder or disease in a mammal wherein the disorder or disease is due to lack or malfunction of endocrine function of pancreas organ and an implant comprising the hydrogel according to the invention.-
公开(公告)号：EP4306548A1
公开(公告)日：2024-01-17
申请号：EP22184567.0
申请日：2022-07-13
申请人： Adocia
摘要： The invention concerns an hydrogel comprising:
- biological cells,
- a non crosslinked hyaluronic acid in the form of a solution, and
- a crosslinked dextran polymer Dx bearing anionic groups wherein the at least divalent radical L(-) i is covalently bound to the dextran polymer backbone with i W radicals, wherein,
- L(-) i is a linear or branched polyether
- i is the valence of L and the number of W radicals bound to the dextran polymer and is an integer comprised from 2 to 8 (2 ≤ i ≤ 8),
- -W- is a radical comprising at least a radical alkyl linear or branched and optionally comprising heteroatoms such as oxygen, nitrogen or sulfur, aromatic cycles, polyether derivatives and that does not comprise two or more alpha aminoacid residues in particular linked by peptidic bond(s).
It also concerns the therapeutic use of the hydrogel according to claim 1, for treating a disorder or disease in a mammal wherein the disorder or disease is due to lack or malfunction of endocrine function of pancreas organ.
It also concerns an implant comprising the hydrogel according to any one of claims 1 to 2.-
公开(公告)号：EP4299598A1
公开(公告)日：2024-01-03
申请号：EP22781612.1
申请日：2022-03-30
摘要： The present invention is intended to provide a hydrogel that utilizes the naturally occurring substance pectin to exhibit an equivalent or greater effect. Specifically, the present application is intended to provide a hydrogel or a patch which is stable, has strong adhesive strength, is advantageous for drug delivery, can be used for sustained treatment, has extremely low cytotoxicity, and is unlikely to induce an immune response, and thus can be used on various body parts, in particular the oral cavity. In addition, the present invention is intended to provide a hydrogel patch which employs a freezing method prior to crosslinking, and thus exhibits superior adhesion to patches employing a post-crosslinking freezing method.
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公开(公告)号：EP3632215B1
公开(公告)日：2024-01-03
申请号：EP19201343.1
申请日：2019-10-03
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公开(公告)号：EP3368085B1
公开(公告)日：2024-01-03
申请号：EP16805919.4
申请日：2016-11-01
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公开(公告)号：EP4294849A1
公开(公告)日：2023-12-27
申请号：EP22707313.7
申请日：2022-02-17
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公开(公告)号：EP4294848A1
公开(公告)日：2023-12-27
申请号：EP22708662.6
申请日：2022-02-17
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