FUNCTIONALIZED CHROMATOGRAPHIC MATERIALS AND METHODS OF MAKING AND USING THEREFOR
    39.
    发明公开
    FUNCTIONALIZED CHROMATOGRAPHIC MATERIALS AND METHODS OF MAKING AND USING THEREFOR 审中-公开
    功能化色谱和方法的生产和使用

    公开(公告)号:EP2600967A2

    公开(公告)日:2013-06-12

    申请号:EP11815387.3

    申请日:2011-08-05

    申请人: Brown University

    摘要: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

    摘要翻译: 如碳 - 碳双键:被用于分离和识别有机分子和化合物,例如分子和含富电子官能团的化合物提供了方法,组合物,试剂盒和具有新颖色谱材料的设备。 所述方法,组合物和试剂盒包括金属硫醇盐层析介质(MTCM)与连接到载体介质中的含硫官能团或含有含硒官能团共价金属selenolates层析介质(MSCM),检查的确 含硫官能团或官能团的含有硒的结合到至少一个金属原子。 的MTCM和/或MSCM具有亲和力和特异性的具有一个或多个碳 - 碳双键的化合物,并且执行产生相对于传统的媒体纯化的物质的非重叠峰样本的高效和快速分离。