公开(公告)号：EP2591367A1

公开(公告)日：2013-05-15

申请号：EP11738258.0

申请日：2011-07-06

申请人： United Arab Emirates University ,  Universita Degli Studi Di Perugia

发明人： EL-AGNAF, Omar ,  PARNETTI, Lucilla ,  CALABRESI, Paolo

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2835

摘要： The present invention relates to method of identifying whether or not an individual has Parkinson's disease (PD). In particular, the invention relates to a method for identifying whether or not an individual has PD as opposed to another neurodegenerative disease. The method of the invention comprises measuring the concentration of a-synuclein (α-syn) and the concentration of unphosphorylated tau (tau) and/or phosphorylated tau (p-tau) in a cerebrospinal fluid sample taken from an individual. The method also comprises calculating the ratio of the concentration of tau and/or p-tau to the concentration of α-syn, and thereby determining whether or not the individual has PD.

公开(公告)号：EP2580225A1

公开(公告)日：2013-04-17

申请号：EP11791943.1

申请日：2011-06-10

申请人： Theracos, Inc.

发明人： CAI, Mengzhuang ,  LIU, Qian ,  XU, Ge ,  LV, Binhua ,  SEED, Brian ,  ROBERGE, Jacques Y.

IPC分类号： C07H7/04 ,  A61K31/70 ,  A61P3/00

CPC分类号： C07H1/06 ,  C07D309/10 ,  C07H7/04

摘要： Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.

公开(公告)号：EP2569306A1

公开(公告)日：2013-03-20

申请号：EP11731557.2

申请日：2011-05-11

申请人： Amgen Inc.

发明人： ALLEN, Jennifer ,  FROHN, Michael ,  HARRINGTON, Paul ,  PICKRELL, Alexander ,  RZASA, Robert ,  SHAM, Kelvin ,  Harrington, Essa Hu

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4523 ,  A61K31/497 ,  A61K31/506 ,  A61P3/00 ,  A61P25/18

CPC分类号： C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Heteroaryloxycarbocyclyl compounds of formula (I), and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive -compulsive disorder, and the like. Formula (I)

摘要翻译： 式（I）的杂芳氧基碳环基化合物和含有它们的组合物，以及制备这些化合物的方法。 本文还提供了治疗可通过抑制PDE10治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相型障碍，强迫症等。 式（I）

公开(公告)号：EP2569299A1

公开(公告)日：2013-03-20

申请号：EP11719750.9

申请日：2011-05-09

申请人： Amgen Inc.

发明人： ALLEN, Jennifer R. ,  ANDREWS, Kristin L. ,  FROHN, Michael J. ,  HARRINGTON, Paul E. ,  PICKRELL, Alexander J. ,  RZASA, Robert M.

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D471/14 ,  A61P3/00 ,  A61P25/00 ,  A61K31/444 ,  A61K31/506 ,  A61K31/4709 ,  A61K31/4375

CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

摘要： Aryl- and heteroaryl-nitrogen heterocyclic compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDEIO, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.

公开(公告)号：EP1558922B1

公开(公告)日：2013-02-27

申请号：EP03781483.7

申请日：2003-10-29

申请人： Ampere Life Sciences, Inc.

发明人： GILAT, Sylvain ,  BINYAMIN, Gary ,  MILLER, Guy

IPC分类号： G01N27/26 ,  G01N33/53 ,  C12Q1/00

CPC分类号： G01N33/6896 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/52

公开(公告)号：EP2558474A1

公开(公告)日：2013-02-20

申请号：EP11730116.8

申请日：2011-04-13

申请人： Rigel Pharmaceuticals, Inc.

发明人： YU, Jiaxin ,  CLOUGH, Jeffrey ,  SINGH, Rajinder

IPC分类号： C07D498/04 ,  A61K31/5383 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D498/04

摘要： The present disclosure provides biologically active 2,4-pyrimidinediamme compounds of formulae (I) and (II): and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications.

公开(公告)号：EP2545025A1

公开(公告)日：2013-01-16

申请号：EP11709279.1

申请日：2011-03-09

申请人： Edison Pharmaceuticals, Inc.

发明人： PAISLEY, Steven, D. ,  LEPREE, Jason, M. ,  HAWI, Amale ,  ECKHOFF, Michael

IPC分类号： C07C46/06 ,  C07D311/72 ,  A61K9/00 ,  A61K31/125 ,  A61P25/00 ,  A61P9/00 ,  A61P13/12 ,  A61P27/02 ,  A61P3/10

CPC分类号： C07D311/72 ,  C07C46/06 ,  C07C50/28

摘要： The present invention is directed to a method of synthesizing a compound of
Formula I: the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of
Formula I , wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of
Formula I , the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of I (b) with a metal salt oxidizing agent to form the compound of
Formula I , wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/aipha-tocopherol is 1.6 to 4.

公开(公告)号：EP2538785A1

公开(公告)日：2013-01-02

申请号：EP11748095.4

申请日：2011-02-24

申请人： Medivation Prostate Therapeutics, Inc.

发明人： THOMPSON, Andrew ,  LAMBERSON, Carol ,  GREENFIELD, Scott ,  JAIN, Rajendra, Parasmal ,  ANGELAUD, Remy

IPC分类号： A01N43/50 ,  A61K31/415

CPC分类号： C07D233/86 ,  C07C231/12 ,  C07C237/30 ,  C07D235/02

摘要： Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

摘要翻译： 提供了合成二芳基硫代乙内酰脲和二芳基乙内酰脲化合物的方法，例如下式化合物：其中X，Y 1，Y 2，R 1和R 2如本文所定义。 含有它们的药物产品特别用于治疗前列腺癌，包括去势抵抗性前列腺癌和/或激素敏感的前列腺癌。

公开(公告)号：EP1871906B1

公开(公告)日：2012-10-10

申请号：EP06740852.6

申请日：2006-04-07

申请人： Linkage Biosciences, Inc.

发明人： ANTOVICH, Zachary

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6858 ,  C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2537/157 ,  C12Q2537/143 ,  C12Q2527/107 ,  C12Q2563/173 ,  C12Q2545/101

公开(公告)号：EP2501787A1

公开(公告)日：2012-09-26

申请号：EP10830995.6

申请日：2010-11-18

申请人： G4 Insights Inc.

发明人： KEEFER, Bowie ,  BABICKI, Matthew L. ,  SELLARS, Brian G. ,  NG, Edson

IPC分类号： C10J3/68 ,  B01D53/44 ,  C10J3/72 ,  C10L3/06 ,  C10L3/08

CPC分类号： C10L3/08 ,  B01J38/12 ,  B01J38/22 ,  C01B3/38 ,  C01B3/503 ,  C01B3/56 ,  C01B2203/0233 ,  C01B2203/0405 ,  C01B2203/042 ,  C01B2203/0475 ,  C01B2203/048 ,  C01B2203/062 ,  C01B2203/148 ,  C10B49/22 ,  C10B53/02 ,  C10G2/32 ,  C10G2300/708 ,  C10K1/026 ,  C10K1/32 ,  C10K3/04 ,  C10L3/104 ,  C10L3/106 ,  C10L2290/02 ,  C10L2290/08 ,  C10L2290/12 ,  C10L2290/38 ,  C25B1/04 ,  Y02E20/16 ,  Y02E50/14 ,  Y02E50/32 ,  Y02E60/366 ,  Y02P20/133 ,  Y02P20/134 ,  Y02P20/145 ,  Y02P20/584

摘要： The present invention provides a system and method for producing hydrocarbons from biomass. The method is particularly useful for producing substitute natural gas from forestry residues. Certain disclosed embodiments convert a biomass feedstock into a product hydrocarbon by fast pyrolysis, and conversion of the resulting pyrolysis gas to the product hydrocarbon and carbon dioxide in the presence of hydrogen and steam while simultaneously generating the required hydrogen by reaction with steam under prescribed conditions for self-sufficiency of hydrogen. Methane is a preferred hydrocarbon product. A system also is disclosed for cycling the catalyst between steam reforming, methanation and regeneration zones.

摘要翻译： 系统和方法的某些方面涉及从生物质产生碳氢化合物。 该方法对于生产来自林业残留物的替代天然气特别有用。 生物质原料可以通过快速热解转化成产物烃。 所得热解气体在氢气和蒸汽的存在下转化为产物烃和二氧化碳，同时通过在规定条件下与蒸汽在氢气自给自足下反应产生所需的氢气。 甲烷是优选的烃产物。 还描述了一种用于在蒸汽重整，甲烷化和再生区之间循环催化剂的系统。