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212 条记录 (耗时 0.015 秒)

    IMIDAZOQUINOLINE COMPOUNDS AND USES THEREOF
    47.
    发明公开
    IMIDAZOQUINOLINE COMPOUNDS AND USES THEREOF 审中-公开

    公开(公告)号：EP4306523A2

    公开(公告)日：2024-01-17

    申请号：EP23188546.8

    申请日：2019-09-05

    申请人： Birdie Biopharmaceuticals, Inc.

    发明人： YANG, Lihu

    IPC分类号： C07D471/04

    摘要： Provided herein are imidazoquinoline derivatives, or pharmaceutically acceptable salts thereof, that are agonists of toll-like receptors 7 and 8 (TLR7/8). Also provided herein are compositions and pharmaceutical compositions comprising the imidazoquinoline derivatives, or pharmaceutically acceptable salts thereof, provided herein. Also provided herein are methods of use of the imidazoquinoline derivatives, or pharmaceutically acceptable salts thereof, provided herein to treat various diseases, such as viral, cancer, and allergic diseases, in a subject in need thereof by administering a therapeutically effective amount of the imidazoquinoline derivative, or pharmaceutically acceptable salt thereof, to the subject.

    METHODS FOR TREATING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN
    48.
    发明公开
    METHODS FOR TREATING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN 审中-公开

    公开(公告)号：EP4306164A2

    公开(公告)日：2024-01-17

    申请号：EP23204861.1

    申请日：2011-08-23

    申请人： Alkermes Pharma Ireland Limited

    发明人： DEAVER, Daniel. ,  TODTENKOPF, Mark.

    IPC分类号： A61P3/04

    摘要： The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical antipsychotic use. The present invention provides methods of reducing antipsychotic induced weight gain, methods for suppressing food intake and reducing ghrelin levels induced by atypical antipsychotic medications in a patient.