公开(公告)号：EP1525480B1

公开(公告)日：2017-09-13

申请号：EP03771940.8

申请日：2003-07-29

申请人： Abbott Point of Care Inc.

发明人： CAMPBELL, John, Lewis, Emerson ,  FRANK, Pamela, Anne ,  HAWKES, Meghan, Elizabeth ,  LOBIN, Shannon, Reishma ,  MILLER, Cary, James ,  YANG, Zhen

IPC分类号： G01N33/58 ,  G01N33/68

CPC分类号： G01N33/54386 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2800/324

公开(公告)号：EP3198271A1

公开(公告)日：2017-08-02

申请号：EP15777817.6

申请日：2015-09-25

申请人： Abbott Point Of Care, Inc.

发明人： DI TULLIO, Katrina Petronilla ,  TAYLOR, Jay Kendall ,  LEE-YOW, Niko Daniel ,  BALL, Sheila Diane

IPC分类号： G01N33/49 ,  B01L3/00

CPC分类号： G01N33/86 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0672 ,  B01L2400/0688 ,  G01N27/403 ,  G01N27/4166 ,  G01N33/4905 ,  G01N2333/96463

摘要： The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.

摘要翻译： 本发明涉及分析测试装置，其包括具有微环境传感器的单通道和用于测定施加到微环境传感器的流体样本中的凝结的方法，并且具体涉及使用具有微环境的单通道执行凝结测定 传感器在点测试盒中。 例如，本发明可以涉及一种样本分析盒，该样本分析盒包括构造成接收生物样本的入口室和流体地连接至入口室的导管。 导管包括传感器芯片和流体锁定阀，传感器芯片包括第一微环境传感器和第二微环境传感器。 所述样本分析盒还包括泵，所述泵被配置为将所述生物样本推过所述第一微环境传感器和所述第二微环境传感器至所述流体锁定阀，使得所述生物样本位于所述第一微环境传感器和所述第二微环境传感器之上， 环境传感器。

公开(公告)号：EP3197603A1

公开(公告)日：2017-08-02

申请号：EP15781488.0

申请日：2015-09-25

申请人： Abbott Point of Care Inc.

发明人： DI TULLIO, Katrina Petronilla ,  TAYLOR, Jay Kendall ,  CAMPBELL, John Lewis Emerson ,  ELBUKEN, Caglar ,  BALL, Sheila Diane ,  LIGHTSTONE, Noam Saul

IPC分类号： B01L3/00

CPC分类号： G01N33/86 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/0672 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N2333/745 ,  G01N2333/974

摘要： The present invention relates to analytical testing devices comprising segmented fluidics and methods for assaying coagulation in a fluid sample received within the segmented fluidics. For example, the present invention may be directed to sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region. The sample analysis cartridge further includes a pump configured to independently mix the first segment in the second conduit and the second segment in the third conduit, and independently position the first segment over the first sensor region and position the second segment over the second sensor region.

摘要翻译： 本发明涉及包括分段流体学的分析测试设备以及用于分析在分段流体学设备内接收的流体样本中的凝结的方法。 例如，本发明可涉及样本分析盒，所述样本分析盒包括入口室，第一导管，第一导管和第二导管，所述第一导管包括构造成将生物样本分成至少第一段和第二段的第一接头，包含第一试剂的第二导管， 区域和第一流体锁定阀，以及第三导管，其包括第一限流器区域，第二试剂和第二传感器区域。 样本分析盒进一步包括泵，该泵构造成独立地混合第二导管中的第一节段和第三导管中的第二节段，并且独立地将第一节段定位在第一传感器区域上并且将第二节段定位在第二传感器区域上。

公开(公告)号：EP2646152B1

公开(公告)日：2017-04-19

申请号：EP11794365.4

申请日：2011-12-01

申请人： Abbott Point of Care Inc.

发明人： MILLER, Cary James

IPC分类号： B01L3/00

CPC分类号： G01N33/5302 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/045 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/126 ,  B01L2400/0481 ,  G01N1/38 ,  G01N2333/4737 ,  Y10T436/25625

公开(公告)号：EP2269038B1

公开(公告)日：2016-07-27

申请号：EP09721546.1

申请日：2009-03-20

申请人： Abbott Point Of Care, Inc.

发明人： LEVINE, Robert, A. ,  WARDLAW, Stephen, C. ,  LALPURIA, Niten, V. ,  UNFRICHT, Darryn, W.

IPC分类号： G01N21/64 ,  G01N15/14 ,  G01N33/50 ,  G01N15/00

CPC分类号： G01N33/49 ,  G01N15/1463 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/48 ,  G01N33/5091 ,  G01N2015/008 ,  G01N2015/1477 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/062

摘要： An apparatus (44) for analyzing a blood sample comprises a chamber (10) configured to quiescently hold the blood sample; an illuminator (46) configured to illuminate the blood sample along one or more fluorescent excitation wavelengths and one or more absorption wavelengths; an image dissector (48) configured to image at least a portion of the blood sample, and produce image signals representative of fluorescent emissions from, and optical density of, first constituents and second constituents disposed within the blood sample, which first constituents are different from the second constituents; and an analysis device (50) configured to determine one or more fluorescent emission values for each of the first constituents and second constituents using the image signals, and adapted to determine one or more optical density values for each of the first constituents and second constituents using the image signals, and adapted to identify the first constituents and the second constituents using the determined fluorescent emission and optical density values.

公开(公告)号：EP2370820B1

公开(公告)日：2016-02-24

申请号：EP09797246.7

申请日：2009-12-30

申请人： Abbott Point Of Care, Inc.

发明人： COLLIER, Gordon Bruce ,  MILLER, Cary James

IPC分类号： G01N33/58

CPC分类号： G01N33/5306 ,  G01N33/5302 ,  G01N33/58 ,  G01N33/6887 ,  G01N2458/10

摘要： A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first nucleotide has one or more repeated sequences, and the second nucleotide is bound to one of the one or more repeated sequences on said first nucleotide, and wherein the ratio of the signal antibody to the signal element is controlled by the number of repeated sequences.

公开(公告)号：EP2271937B1

公开(公告)日：2016-01-13

申请号：EP09722141.0

申请日：2009-03-20

申请人： Abbott Point Of Care, Inc.

发明人： WARDLAW, Stephen C. ,  LEVINE, Robert A. ,  LALPURIA, Niten V.

IPC分类号： G01N15/02 ,  G01N33/50 ,  G01N15/00 ,  G01N33/49 ,  G01N15/14 ,  G01N33/80 ,  G01N33/58

CPC分类号： G01N33/49 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/0092 ,  G01N2015/1486

公开(公告)号：EP2959276A1

公开(公告)日：2015-12-30

申请号：EP14754884.6

申请日：2014-02-19

申请人： Abbott Point of Care Inc.

发明人： MEHTA, Manav ,  HOLT, Robert

IPC分类号： G01J3/51

CPC分类号： G01N21/0303 ,  B01L3/502715 ,  B01L3/502746 ,  G01N21/59 ,  G01N21/6428 ,  G01N33/49 ,  G01N2021/0307 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2201/064

摘要： A biological fluid sample analysis chamber and a method for analyzing a biological fluid sample is provided. The chamber includes a first chamber panel, a second chamber panel, and a plurality of beads disposed between the first chamber panel and the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the biologic fluid.

公开(公告)号：EP2929345A1

公开(公告)日：2015-10-14

申请号：EP13860899.7

申请日：2013-12-06

申请人： Abbott Point Of Care, Inc.

发明人： XIE, Min ,  WARDLAW, Stephen C.

IPC分类号： G01N33/48 ,  G06K9/28

CPC分类号： G01N33/49 ,  G01N15/0227 ,  G01N15/1463 ,  G01N21/6458 ,  G01N33/483 ,  G01N2015/0065 ,  G06K9/00127 ,  G06K9/00134 ,  G06K9/0014

摘要： A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

摘要翻译： 用于分析生物流体样品的方法包括以下步骤：a）提供空间映射的室; b）提供样品内一个或多个组分的预定的可重复的非均匀空间分布，该分布指示每个室子区域中样品中统计学上显着数量的组分的存在或不存在; c）根据该分布中指示的该子区域中统计学上显着数量的一个或多个成分的存在或不存在，为每个子区域选择一个或多个图像技术; d）使用为该子区域选择的一种或多种图像技术来创建代表每个子区域中的生物液体样品的图像数据; 和e）分析样品。

公开(公告)号：EP2658653B1

公开(公告)日：2015-03-04

申请号：EP11811299.4

申请日：2011-12-30

申请人： Abbott Point Of Care, Inc.

发明人： VERRANT, John ,  LALPURIA, Niten ,  WARDLAW, Stephen

IPC分类号： B01L3/00

CPC分类号： B01L3/502707 ,  B01L3/5027 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/0861

摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.