摘要:
The present invention relates to a counting compartment or counting chamber for analyzing samples comprising cells or particles, said counting compartment or chamber comprising at least two different depths provided by the bottom and top measurement window. The present invention further relates to a counting device comprising the counting compartment or counting chamber of the present invention. The present invention further relates to a method for analyzing samples comprising cells or particles, comprising the step of determining the difference between the value measured at the at least two different depths of a counting compartment or counting chamber. The present invention further relates to a method for analyzing samples comprising cells or particles, comprising the step of controlling the depth of a counting compartment.
摘要:
Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1. Some embodiments further include a multi-camera configuration. These embodiments include a first camera module and a second camera module arranged to capture one or more images of the first holding area and the second holding area, respectively. The processor may perform different analytic processes on the captured images of different holding areas to determine an outcome with regard to the biological specimen.
摘要:
This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.
摘要:
An analysis device includes a turntable, an optical pickup, and a controller. The turntable holds a disc for specimen analysis having a reaction region on which fine particles binding to substances to be detected are captured per track. The optical pickup emits laser light to the reaction region, receives a reflected light from the reaction region, and generates a reception level signal of the light. The controller sequentially generates a plurality of measurement gate signals per track for counting the number of the fine particles captured on the reaction region, counts the number of the fine particles per measurement gate signal from the reception level signal, compares measurement results obtained in positions having a symmetric relation with each other in the reaction region, and defines a measurement-result-correction target region for correcting the number of the fine particles.
摘要:
Fluid may be pumped within a microfluidic channel across a cell/particle sensor using a microscopic resistor. The microscopic resistor may be selectively actuated so as to heat the fluid within the microfluidic channel to a temperature below a nucleation energy of the fluid so as to regulate a temperature of the fluid for at least when the cell/particle sensor is sensing the fluid.
摘要:
There is provided an art capable of detecting viable particles in a liquid and counting the number of the viable particles even if there is an influence of a Raman-scattered light by water. There are provided: a light emitting means (10) which radiates a light with a predetermined wavelength toward a liquid containing a detection target; an autofluorescence selecting optical means (70) which reduces transmission of a Raman-scattered light emitted from the liquid out of lights emitted due to an interaction of the target or the liquid with the light radiated from the light emitting means (10) and transmits an autofluorescence emitted from the target; and a viable particle determining means (2) which determines whether or not the target contained in the liquid is a viable particle, based on a light obtained after the Raman-scattered light is reduced by the autofluorescence selecting optical means (70), and the light emitting means (10) radiates the light with the predetermined wavelength that causes the autofluorescence and the Raman-scattered light to be different in peak wavelength.
摘要:
An apparatus for assessment of a fluid system includes a scaffold housing with a plurality of internal cavities; a debris monitor module assembly to be selectively inserted into a first cavity of the plurality of internal cavities, the debris monitor module assembly to determine wear debris information in a lubricant; a lubricant condition monitor module assembly to be selectively inserted into a second cavity of the plurality of internal cavities, the lubricant condition monitor module assembly to determine lubricant condition information in the lubricant; and a processing module assembly that is configured to be selectively inserted into a third cavity of the plurality of internal cavities, the processing module assembly to provide communication to an external interface of at least one of the wear debris information and the lubricant condition information.
摘要:
A cytological analysis test for 3D cell classification from a specimen. The method includes isolating and preserving a cell from the specimen and enriching the cell before embedding the enriched cell into an optical medium. The embedded cell is injected into a capillary tube where pressure is applied until the cell appears in a field of view of a pseudo-projection viewing subsystem to acquire a pseudo-projection image. The capillary tube rotates about a tube axis to provide a set of pseudo-projection images for each embedded cell which are reconstructed to produce a set of 3D cell reconstructions. Reference cells are classified and enumerated and a second cell classifier detects target cells. An adequacy classifier compares the number of reference cells against a threshold value of enumerated reference cells to determine specimen adequacy.