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公开(公告)号：EP3402779A1
公开(公告)日：2018-11-21
申请号：EP17700388.6
申请日：2017-01-13
IPC分类号： C07D223/04 , C07D401/12 , A61K31/55 , A61P29/00
CPC分类号： C07D223/04 , C07D401/12
摘要： The present invention relates to 3-ethyl-3-phenylazepane derivatives having dual pharmacological activity towards both the sigma (σ) receptor and the μ- opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
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公开(公告)号：EP3858439A1
公开(公告)日：2021-08-04
申请号：EP20382068.3
申请日：2020-02-03
发明人： ALMANSA-ROSALES, Carmen , VIRGILI-BERNADÓ, Marina , ALONSO-XALMA, Mónica , OSORIO-PLANES, Laura
IPC分类号： A61P35/04 , A61K31/4468 , A61K31/4523 , C07D205/06 , C07D211/58 , C07D401/06
摘要： The present invention relates to new compounds that show pharmacological activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the µ-opiod receptor (MOR or mu-opioid). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
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公开(公告)号：EP3519569B1
公开(公告)日：2020-12-02
申请号：EP17777541.8
申请日：2017-09-22
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公开(公告)号：EP3700890A1
公开(公告)日：2020-09-02
申请号：EP18800058.2
申请日：2018-10-26
IPC分类号： C07D223/10 , A61K31/381 , A61K31/55 , A61K31/5513 , C07D409/12 , C07D243/08 , C07D243/14 , C07D487/02 , A61P29/00
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公开(公告)号：EP3697754A1
公开(公告)日：2020-08-26
申请号：EP18783536.8
申请日：2018-10-16
IPC分类号： C07C217/76 , C07C233/25 , C07C233/67 , C07C235/46 , C07C235/50 , C07C235/56 , C07C237/06 , C07C237/40 , C07D213/75 , C07D213/82 , C07D333/20 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/48 , C07D409/12 , C07D413/12 , C07D271/10 , C07D211/58
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公开(公告)号：EP3658550A1
公开(公告)日：2020-06-03
申请号：EP18743038.4
申请日：2018-07-27
发明人： VIRGILI-BERNADÓ, MARINA, Marina , ALMANSA-ROSALES, Carmen , ALONSO-XALMA, Mónica , OSORIO-PLANES, Laura
IPC分类号： C07D409/06 , C07D471/04 , A61K31/4045 , A61K31/437 , A61P25/04
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公开(公告)号：EP3083595B1
公开(公告)日：2020-05-27
申请号：EP14816259.7
申请日：2014-12-19
发明人： CUEVAS CORDOBES, Felix , ALMANSA-ROSALES, Carmen , AYET GALCERA, Eva Maria , SERAFINI CABANES, Maria Teresa , GARCIA LOPEZ, Monica
IPC分类号： C07D401/14 , C07D401/06 , A61K31/4439 , A61P25/04 , A61P25/06
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48.发明公开
公开(公告)号：EP3630765A1
公开(公告)日：2020-04-08
申请号：EP18726484.1
申请日：2018-05-29
发明人： ALMANSA-ROSALES, Carmen , DIAZ-FERNANDEZ, José-Luís , FERNANDEZ-DONIS, Ariadna , YENES-MINGUEZ, Susana
IPC分类号： C07D487/04 , A61K31/045
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公开(公告)号：EP2989105B1
公开(公告)日：2020-03-11
申请号：EP14720074.5
申请日：2014-04-22
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/55 , A61P29/00
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公开(公告)号：EP3519569A1
公开(公告)日：2019-08-07
申请号：EP17777541.8
申请日：2017-09-22
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