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41.发明公开
公开(公告)号：EP4395834A1
公开(公告)日：2024-07-10
申请号：EP22865525.4
申请日：2022-08-31
IPC分类号： A61K47/68 , C07D271/113 , A61K51/04 , A61K51/10
CPC分类号： C07D271/113 , A61K51/1051
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公开(公告)号：EP3319685B1
公开(公告)日：2020-08-05
申请号：EP16815241.1
申请日：2016-06-22
发明人： AHMED, Zaghloul
IPC分类号： A61N1/36
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公开(公告)号：EP3624791A1
公开(公告)日：2020-03-25
申请号：EP18802494.7
申请日：2018-05-17
发明人： ZEGLIS, Brian , ADUMEAU, Pierre , DAVYDOVA, Maria
IPC分类号： A61K31/4245 , A61K31/5395 , A61K47/66 , C07D271/10 , C07K1/107 , C07K1/13
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公开(公告)号：EP3140407B1
公开(公告)日：2020-03-18
申请号：EP15789568.1
申请日：2015-05-11
发明人： ORTIZ, Benjamin, D. , LAHIJI, Armin
IPC分类号： C12N15/85 , C07K14/725
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公开(公告)号：EP3104856B1
公开(公告)日：2020-01-08
申请号：EP15749116.8
申请日：2015-02-11
IPC分类号： A61K31/385 , A61K31/621 , A61K31/625 , A01N33/00
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公开(公告)号：EP2964315B1
公开(公告)日：2018-08-29
申请号：EP14760682.6
申请日：2014-03-07
发明人： AHMED, Zaghloul
IPC分类号： A61N1/02 , A61N1/04 , A61N1/05 , A61N1/06 , A61N1/18 , A61N1/20 , A61N1/32 , A61N1/34 , A61N1/372 , A61N2/00 , A61N1/36 , A61N2/02
CPC分类号： A61N1/36103 , A61N1/0456 , A61N1/36014 , A61N1/36025 , A61N2/002 , A61N2/006 , A61N2/02
摘要： Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.
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公开(公告)号：EP3140407A1
公开(公告)日：2017-03-15
申请号：EP15789568.1
申请日：2015-05-11
发明人： ORTIZ, Benjamin, D. , LAHIJI, Armin
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C07K14/7051 , C12N2740/15043 , C12N2830/46
摘要： A method of delivering a transgene to a cell is provided. The method uses a vector that contains a T-cell receptor alpha locus control region (TCRαLCR) derived gene regulatory cassette having fewer than 5.0-kb. The method delivers the transgene with spatiotemporally specific gene expression and silencing-prevention controls to a cell such that a predetermined subset of progeny cell-types express a gene product from the transgene. Other progeny of the cell diminish, or silence, the expression of the gene product.
摘要翻译： 提供了将转基因递送至细胞的方法。 该方法使用含有小于5.0-kb的T细胞受体α基因座控制区（TCRαLCR）衍生的基因调控盒的载体。 该方法将具有时空特异性基因表达的转基因和沉默预防对照递送至细胞，使得子代细胞类型的预定子集表达来自转基因的基因产物。 细胞的其他后代减少或沉默基因产物的表达。
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50.发明公开METHOD OF PRIMING PLANTS AGAINST ABIOTIC STRESS FACTORS AND PROMOTING GROWTH 审中-公开PROCESS植物对抗因素非生物胁迫促生长的制备
公开(公告)号：EP3104856A1
公开(公告)日：2016-12-21
申请号：EP15749116.8
申请日：2015-02-11
申请人： The City University Of New York Represented By The Research Foundation Of The City University Of New York , Cyprus University of Technology
IPC分类号： A61K31/385
摘要： A method of reducing cellular damage to a plant by treating the plant with a compound containing an NO-releasing moiety and an H2S-releasing moiety covalently bonded to an aspirin derived core or a NOSH compound is claimed. The compounds may also be used in a method of priming a plant against abiotic stress factors and a method of promoting plant growth.
摘要翻译： 通过用含有的NO释放部分的化合物处理植物减少到植物细胞损伤和H 2 S - 释放部分的方法，共价结合到在阿司匹林衍生芯或NOSH化合物主张的内容。 化合物因此可以在吸对非生物应力因素的植物和宣传婷植物生长的方法的方法中使用。
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