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公开(公告)号：EP4237086A1
公开(公告)日：2023-09-06
申请号：EP21810231.7
申请日：2021-10-26
申请人： Amgen Inc.
发明人： LANMAN, Brian Alan , BANERJEE, Abhisek , CHU-MOYER, Margaret , DAI, Dongcheng , KALLER, Matthew R. , LOPEZ, Patricia , MA, Vu Van , MANONI, Francesco , MEDINA, Jose M. , PICKRELL, Alexander J. , TAMAYO, Nuria A. , ZHU, Kai
IPC分类号： A61P35/00 , C07D487/10 , C07D491/04 , C07D513/04 , A61K31/506 , A61K31/519 , A61K31/541 , A61K31/517 , A61K31/5395
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2.发明授权
公开(公告)号：EP3733665B1
公开(公告)日：2022-09-28
申请号：EP18893819.5
申请日：2018-12-25
发明人： SHIKANAI Daisuke , ISHIGURO Noriko , OMORI Osamu
IPC分类号： C07D417/14 , A61K31/5395 , A61K31/549 , A61P19/08 , A61P43/00 , C07D417/06
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公开(公告)号：EP3744328A1
公开(公告)日：2020-12-02
申请号：EP19382446.3
申请日：2019-05-31
发明人： HERNÁNDEZ CABANILLAS, Alfredo , MADERUELO CORRAL, Santiago , ORTEGA DOMÉNECH, Montserrat , ROSERO VALENCIA, Diego Fernando , RUMBERO SÁNCHEZ, Ángel , TENA PÉREZ, Víctor , APAZA TICONA, Luis Néstor
IPC分类号： A61K31/5395 , A61P9/00 , A61P17/18 , A61P37/00
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer or solvate thereof for use in the prevention and/or treatment of a pathology associated with proinflammatory conditions, a disease associated with oxidative stress or production of reactive oxygen species or a skin pigmentation disorder. In addition, the invention also relates to a cosmetic method for preventing and/or treating skin aging, irradiated skin or for skin-whitening comprising administering a compound of formula (I) or a cosmetically acceptable salt, stereoisomer or solvate thereof. In addition, the invention relates to a method of inhibition of enzymatic browning in food or beverage comprising contacting said food or beverage with a compound of formula (I) or a salt, stereoisomer or solvate thereof under conditions sufficient to inhibit enzymatic browning of said food or beverage.
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公开(公告)号：EP3624791A1
公开(公告)日：2020-03-25
申请号：EP18802494.7
申请日：2018-05-17
发明人： ZEGLIS, Brian , ADUMEAU, Pierre , DAVYDOVA, Maria
IPC分类号： A61K31/4245 , A61K31/5395 , A61K47/66 , C07D271/10 , C07K1/107 , C07K1/13
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公开(公告)号：EP3395805A1
公开(公告)日：2018-10-31
申请号：EP17382224.8
申请日：2017-04-26
发明人： HERNÁNDEZ CABANILLAS, Alfredo , MADERUELO CORRAL, Santiago , ORTEGA DOMÉNECH, Montserrat , ROSERO VALENCIA, Diego Fernando , RUMBERO SÁNCHEZ, Ángel , TENA PÉREZ, Víctor
IPC分类号： C07D273/04 , A61K31/5395 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00
摘要： The invention relates to novel compounds of formula (I), wherein one Z is N and the other is -C-R 2 , and their use in medicine, particularly in treating and /or preventing infections caused by a bacterium, fungus or virus or in treating and/or preventing cancer. Additionally, the invention relates to a process for obtaining the compounds of the invention.
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6.发明授权
公开(公告)号：EP2448587B1
公开(公告)日：2018-08-22
申请号：EP10732580.5
申请日：2010-07-02
申请人： Alcon Research, Ltd.
IPC分类号： A61K31/5383 , A61K31/5395 , A61K9/00 , A61P31/04 , A61P27/02 , A61K31/535 , A61K45/06
CPC分类号： A61K31/5383 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K31/535 , A61K31/5395 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.
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公开(公告)号：EP2507219B1
公开(公告)日：2018-05-09
申请号：EP10835172.7
申请日：2010-12-03
发明人： PIRRUNG, Michael, C.
IPC分类号： C07D273/02 , C07D285/00 , C07D245/02 , A61K31/5395 , A61K31/549 , A61P35/00 , A61P29/00
CPC分类号： C07K5/0202 , A61K38/06 , A61K45/06 , C07D245/02 , C07D273/02 , C07D285/00
摘要： The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
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8.发明授权TRICARBONYL TECHNETIUM-99M OR RHENIUM-188 LABEL RING RGD DERIVATIVE, A PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVE AS AN ACTIVE INGREDIENT FOR USE IN THE DIAGNOSIS OR TREATMENT OF ANGIOGENESIS-RELATED DISEASES 有权二烯三羰锝-99m或铼188MARKIERUNGSRING-RGD衍生物PROCESS FOR作为活性成分FOR USE在诊断和治疗血管生成相关疾病的导数产生与药物组合物
公开(公告)号：EP2583966B1
公开(公告)日：2016-08-10
申请号：EP11786882.8
申请日：2011-05-24
发明人： LEE, Byung Chul , KIM, Sang Eun , KIM, Ji Sun , MOON, Byung Seok , JUNG, Jae Ho
IPC分类号： C07D273/06 , C07D498/06 , C07D498/16 , A61K31/5395 , A61K51/04 , G01N33/60 , A61P35/00 , A61K51/08 , C07K7/64 , G01N33/574
CPC分类号： A61K51/088 , A61K51/082 , C07D273/06 , C07D498/06 , C07D498/16 , C07K7/64 , G01N33/574 , G01N33/60
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9.发明授权3-(3-AMINOPIPERIDIN-1-YL)-5-OXO-1,2,4-TRIAZINE DERIVATES AS DIPEPTIDYL PEPTIDASE IV(DPP-IV) INHIBITORS 有权3-（3-氨基哌啶-1-基）-5-氧代-1,2,4-三嗪衍生物酸脱氢酶IV（DPP IV）-HEMMER
公开(公告)号：EP2521721B1
公开(公告)日：2014-10-01
申请号：EP10840567.1
申请日：2010-12-28
发明人： WANG, Weibo , LI, Tongshuang
IPC分类号： C07D401/04 , A61K31/53 , A61K31/5395 , A61P3/10
CPC分类号： C07D401/04
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公开(公告)号：EP2507219A4
公开(公告)日：2014-08-06
申请号：EP10835172
申请日：2010-12-03
申请人： UNIV CALIFORNIA
发明人： PIRRUNG MICHAEL C
IPC分类号： C07D273/02 , A61K31/5395 , A61K31/549 , A61P29/00 , A61P35/00 , C07D245/02 , C07D285/00
CPC分类号： C07K5/0202 , A61K38/06 , A61K45/06 , C07D245/02 , C07D273/02 , C07D285/00
摘要： The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
摘要翻译： 本公开一般涉及制备天然化合物家族，所述syrbactins及其类似物的方法。
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