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    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    44.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2661626A2

    公开(公告)日：2013-11-13

    申请号：EP12732048.9

    申请日：2012-01-08

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Angiopoietinrelated protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparin-binding growth factor 1, Angiopoietin-related protein 6, Proepiregulin, Probetacellulin, Amphiregulin, Angiogenin, Thrombospondin-2, and Collagen alpha-1(XVIII) chain as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置为检测选自以下的肾损伤标志物的测定法：结合肝素的EGF-生长因子，腱生蛋白C，血管生成素相关蛋白4，成纤维细胞生长因子19，成纤维细胞 生长因子21，肝素结合生长因子1，血管生成素相关蛋白6，促纤维蛋白原，Probetacellulin，双调蛋白，血管生成素，血小板反应蛋白-2和胶原蛋白α-1（XVIII）链作为肾损伤中的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE IN A NON-SURGICAL ICU POPULATION
    46.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE IN A NON-SURGICAL ICU POPULATION 审中-公开
    非手术ICU人群的肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2542697A1

    公开(公告)日：2013-01-09

    申请号：EP11751238.4

    申请日：2011-03-01

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James Patrick

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/6893 ,  G01N33/5091 ,  G01N33/74 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects admitted to a hospital critical care setting for other than a post-surgical or trauma indication. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Insulin-like growth factor IA, soluble Epidermal growth factor receptor, and Leukocyte elastase as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定在除了手术后或创伤指征以外的住院危重护理环境中的受试者中的治疗方案的方法和组合物。 具体而言，本发明涉及使用检测一种或多种选自胰岛素样生长因子1A，可溶性表皮生长因子受体和白细胞弹性蛋白酶的标志物作为肾损伤中诊断和预后生物标志物的测定法。

    DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    48.
    发明公开
    DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    诊断和肾功能衰竭和肾脏病变预后

    公开(公告)号：EP2393934A1

    公开(公告)日：2011-12-14

    申请号：EP10739152.6

    申请日：2010-02-05

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/6893 ,  G01N2333/50 ,  G01N2800/347 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble Advanced glycosylation end product- specific receptor, Bactericidal permeability-increasing protein, Interleukin 12, Fibroblast growth factor 23, Vitamin K-dependent protein C, and Intestinal fatty acid-binding protein as diagnostic and prognostic biomarkers in renal injuries.

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    49.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    方法和组合物诊断和预后肾损伤和肾功能衰竭的

    公开(公告)号：EP2364444A1

    公开(公告)日：2011-09-14

    申请号：EP09822669.9

    申请日：2009-10-21

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin

    IPC分类号： G01N33/48

    CPC分类号： G01N33/573 ,  G01N33/5088 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/56 ,  G01N2800/60

    摘要： Disclosed are methods and compositions for monitonng, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury The methods use assays that detect one or more markers selected from the group consisting of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, SIOO-AI2, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2, soluble Hepatocyte growth factor receptor, Interleukin-I receptor antagonist, Interleukin-I beta, lnterleukιn-10, lnterieukιn-15, lnterieukιn-3, Myeloperoxidase, Nidogen-I, soluble Oxidized low-density lipoprotein receptor I, Pappalysin-I, soluble P-selectin glycoprotein ligand I, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinaseI, Tissue inhibitor of metalloproteinase 2, soluble Tumor necrosis factor, soluble Vascular cell adhesion molecule I, and Vascular endothelial growth factor A.