公开(公告)号：EP3049524A1

公开(公告)日：2016-08-03

申请号：EP14849379.4

申请日：2014-09-26

申请人： Duke University

发明人： HAYNES, Barton, F. ,  PERMAR, Sallie ,  MOODY, M., Anthony ,  GAO, Feng ,  LIAO, Hua-Xin ,  TOMARAS, Georgia ,  MONTEFIORI, David, C.

IPC分类号： C12N15/49 ,  C07K14/16 ,  A61K31/7088 ,  A61P31/18 ,  G01N33/50

CPC分类号： A61K31/7088 ,  A61K2039/505 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2770/00041 ,  G01N33/56988 ,  G01N2800/50

摘要： The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.

摘要翻译： 本发明提供诱导和增强抗体应答的组合物和方法，包括但不限于在有需要的受试者中结合HIV-1的IgG应答，其中所述抗体应答的诱导/升高的血浆水平，例如V3和/或 CD4结合位点抗体应答超过阈值水平，与HIV-1的母婴传播风险（MTCT）相关。

公开(公告)号：EP2822599A1

公开(公告)日：2015-01-14

申请号：EP13757076.8

申请日：2013-03-05

申请人： Duke University

发明人： MOODY, M., Anthony ,  HAYNES, Barton, F.

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  A61K31/18

CPC分类号： A61K39/21 ,  A61K31/01 ,  A61K39/12 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  C12N7/00 ,  C12N2740/16134

摘要： The present invention relates, in general, to a method of inducing an immune response to HlV-1 in a mammal and, in particular, to a vaccine formulation suitable for use in such a method comprising an HIV-1 envelope (Env) immunogen comprising recombinant Envs with some degree of high- mannose glycan residues and a Toll-like receptor (TLR) agonist-supplemented squalene-based adjuvant.

公开(公告)号：EP2739312A2

公开(公告)日：2014-06-11

申请号：EP12819608.6

申请日：2012-08-03

申请人： Children's Medical Center Corporation ,  Duke University

发明人： WHITTLE, James ,  HARRISON, Stephen, C. ,  HAYNES, Barton, F. ,  LIAO, Hua-xin ,  MOODY, M., Anthony ,  KEPLER, Thomas, B. ,  SCHMIDT, Aaron, G

IPC分类号： A61K39/395 ,  A61K31/728 ,  A61K38/16 ,  A61K38/17 ,  A61K47/48 ,  A61P31/16 ,  A61P31/00

CPC分类号： C07K16/1018 ,  A61K31/713 ,  A61K38/02 ,  A61K47/6841 ,  A61K51/1006 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76

摘要： The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.

公开(公告)号：EP2739300A2

公开(公告)日：2014-06-11

申请号：EP12807743.5

申请日：2012-07-05

申请人： Duke University ,  Children's Medical Center Corporation ,  The Government of The US, as Represented by The Secretary of the Army, on behalf of Walter Reed Army Institute of Research

发明人： KIM, Jerome ,  HARRISON, Stephen ,  HAYNES, Barton, F. ,  TOMARAS, Georgia, D. ,  MICHAEL, Nelson

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K39/245 ,  A61K48/00 ,  A61P37/00 ,  A61P31/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/6075 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2319/40 ,  C12N2710/16622 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.

公开(公告)号：EP2707388A2

公开(公告)日：2014-03-19

申请号：EP12782672.5

申请日：2012-03-23

申请人： Duke University ,  The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： MASCOLA, John, R. ,  NABEL, Gary ,  HAYNES, Barton, F. ,  WU, Xueling ,  KEPLER, Thomas, B. ,  KWONG, Peter

IPC分类号： C07K16/10 ,  C12N15/13 ,  A61K39/42 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61K39/42 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/56988

摘要： Antibody VRC01 represents a human immunoglobulin that neutralizes—˜90% of diverse HIV-1 isolates. To understand how such broadly neutralizing HIV-1 antibodies develop and recognize the viral envelope, we used X-ray crystallography and 454 pyrosequencing to characterize additional antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding of different antibodies to the same CD4-binding-site epitope. Antibody recognition was achieved through the evolution of complementary contact domains that were generated in diverse ways. Phylogenetic analysis of expressed heavy and light chains determined by deep sequencing revealed a common pathway of antibody heavy chain maturation confined to IGHV1-2*02 lineage that could pair with different light chains. The maturation pathway inferred by antibodyomics reveals that diverse antibodies evolve to a highly affinity-matured state to recognize an invariant viral structure, providing insight into the development and evolution of broadly neutralizing HIV-1 immunity.

公开(公告)号：EP2694542A2

公开(公告)日：2014-02-12

申请号：EP12768353.0

申请日：2012-04-09

申请人： Duke University ,  The Government of The United States, as represented by The Secretary of The Army, on behalf of Walter Reed Army

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  MOODY, M., Anthony ,  TOMARAS, Georgia, D. ,  KIM, Jerome ,  MICHAEL, Nelson

IPC分类号： C07K16/08 ,  C07K16/28 ,  C12N15/13 ,  A61K39/42 ,  A61P31/22

CPC分类号： C07K16/087

摘要： The present invention relates, in general to herpes simplex virus (HSV) and, particular, to antibodies that are specific for glycoprotein D (gD) of HSV. The invention also relates to prophylactic and therapeutic uses of such antibodies.

公开(公告)号：EP2413689A2

公开(公告)日：2012-02-08

申请号：EP10759552.2

申请日：2010-04-05

申请人： Duke University

发明人： HAYNES, Barton, F. ,  VERKOCZY, Laurent, K.

IPC分类号： A01K67/027 ,  C12N15/13 ,  C07K16/18 ,  C07K16/10 ,  G01N33/53 ,  G01N33/15

CPC分类号： C07K16/18 ,  A01K67/0275 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0337 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/1045 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/8509 ,  G01N33/5052 ,  G01N33/5088 ,  G01N33/6854 ,  G01N2333/16

摘要： The present invention relates, in general, to animal models suitable for testing candidate immunogens and, in particular, to knock-in mice expressing heavy and light chains of membrane proximal external region (MPER) HIV-I broadly neutralizing antibodies and to methods of screening candidate immunogens using same.

公开(公告)号：EP2335069A2

公开(公告)日：2011-06-22

申请号：EP09816574.9

申请日：2009-09-24

申请人： Duke University

发明人： TOMARAS, Georgia ,  HAYNES, Barton, F. ,  LIU, Pinghuang ,  YATES, Nicole ,  HWANG, Kwan-Ki

IPC分类号： G01N33/53 ,  C12Q1/68 ,  C07K16/10

CPC分类号： C07K16/1063 ,  G01N33/56988

摘要： The present invention relates, in general, to HIV and, in particular to a method of detecting anti-HIV antibodies and antibody-HIV virion complexes.

公开(公告)号：EP2331104A2

公开(公告)日：2011-06-15

申请号：EP09811855.7

申请日：2009-09-08

申请人： Duke University

发明人： HAYNES, Barton, F.

IPC分类号： A61K31/685 ,  A61P31/18

CPC分类号： A61K31/685 ,  A61K9/0019 ,  A61K9/006 ,  A61K39/0005 ,  A61K39/0012 ,  A61K2039/53 ,  A61K2039/55572 ,  A61K2039/6037 ,  A61K2039/6081

公开(公告)号：EP0931138A1

公开(公告)日：1999-07-28

申请号：EP97910881.0

申请日：1997-10-10

申请人： DUKE UNIVERSITY

发明人： HAYNES, Barton, F. ,  PATEL, Dhavalkumar, D. ,  SMITH, Clayton, A. ,  MIRALLES, G., Diego

IPC分类号： A61K35 ,  A61K39 ,  A61K48 ,  A61P3 ,  A61P25 ,  A61P31 ,  A61P35 ,  A61P37 ,  C12N5 ,  A61K38

CPC分类号： C12N5/0639 ,  A61K38/00 ,  A61K2039/5154 ,  C12N5/065 ,  C12N2500/40 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/25 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1185 ,  C12N2502/13

摘要： The present invention relates, in general, to thymic microenvironment and, in particular, to a method of producing a thymic microenvironment. The invention further relates to a method of treating congenital and acquired immunodeficiencies using a thymic microenvironment produced in vitro. Included in acquired immunodeficiencies are syndromes seen in malignant and autoimmune diseases as well as traditional T cell immunodeficiency diseases such as occurs in AIDS.