公开(公告)号：EP2556148A2

公开(公告)日：2013-02-13

申请号：EP11766283.3

申请日：2011-04-11

申请人： Duke University

发明人： HAYNES, Barton, F. ,  BONSIGNORI, Mattia ,  HWANG, Kwan-Ki ,  LIAO, Hua-Xin ,  MONTEFIORI, David, C. ,  LUFTIG, Micah, A.

IPC分类号： C12N5/0781 ,  C12N5/10 ,  C07K16/18

CPC分类号： C07K16/00 ,  C07K16/1045 ,  C07K2317/76

摘要： The present invention relates, in general, to human B cells, and, in particular to a method of immortalizing and cloning human B cells and to monoclonal antibodies derived therefrom. The invention further relates to methods of using the monoclonal antibodies for therapeutic and diagnostic purposes.

公开(公告)号：EP3049524A1

公开(公告)日：2016-08-03

申请号：EP14849379.4

申请日：2014-09-26

申请人： Duke University

发明人： HAYNES, Barton, F. ,  PERMAR, Sallie ,  MOODY, M., Anthony ,  GAO, Feng ,  LIAO, Hua-Xin ,  TOMARAS, Georgia ,  MONTEFIORI, David, C.

IPC分类号： C12N15/49 ,  C07K14/16 ,  A61K31/7088 ,  A61P31/18 ,  G01N33/50

CPC分类号： A61K31/7088 ,  A61K2039/505 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2770/00041 ,  G01N33/56988 ,  G01N2800/50

摘要： The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.

摘要翻译： 本发明提供诱导和增强抗体应答的组合物和方法，包括但不限于在有需要的受试者中结合HIV-1的IgG应答，其中所述抗体应答的诱导/升高的血浆水平，例如V3和/或 CD4结合位点抗体应答超过阈值水平，与HIV-1的母婴传播风险（MTCT）相关。