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41.发明公开GAPPED OLIGOMERIC COMPOUNDS HAVING LINKED BICYCLI CSUGAR MOIETIES AT THE TERMINI 审中-公开GAP的前传低聚物链接相关二环糖集团对条款
公开(公告)号：EP1670810A2
公开(公告)日：2006-06-21
申请号：EP04788694.0
申请日：2004-09-09
CPC分类号： C07H21/04
摘要： The present invention relates to bicyclic nucleosides and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity and nuclease resistance properties compared to unmodified oligomeric compounds. The oligomeric compounds are useful, for example, for investigate and therapeutic purpose.
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公开(公告)号：EP1668130A2
公开(公告)日：2006-06-14
申请号：EP04784326.3
申请日：2004-09-17
发明人： FREIER, Susan, M. , DOBIE, Kenneth, W. , MARCUSSON, Eric, G. , SWAYZE, Eric, E. , BHAT, Balkrishen , GRAFF, Jeremy, R. , KONICEK, Bruce, W.
IPC分类号： C12N15/11 , A61K31/7088 , A61K31/713 , A61P35/00 , A61P9/00
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
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43.发明公开POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION 有权多环芳烃SUGAR SPARE LEG AMUSING低聚物化合物和组合物用于基因调节
公开(公告)号：EP1562971A2
公开(公告)日：2005-08-17
申请号：EP03768647.4
申请日：2003-11-04
发明人： ALLERSON, Charles , BHAT, Balkrishen , ELDRUP, Ann, B. , MANOHARAN, Muthiah , GRIFFEY, Richard , BAKER, Brenda, F. , SWAYZE, Eric, E.
CPC分类号： C12N15/1135 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2310/53
摘要： Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.
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公开(公告)号：EP2173760B2
公开(公告)日：2015-11-04
申请号：EP08780773.1
申请日：2008-06-06
发明人： SETH, Punit, P. , SWAYZE, Eric, E.
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公开(公告)号：EP2906256A2
公开(公告)日：2015-08-19
申请号：EP13845550.6
申请日：2013-10-11
CPC分类号： C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2320/34 , C12N2310/321 , C12N2310/3525 , C12N2310/322 , C12N2310/3533
摘要： The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount, activity, or expression of the target nucleic acid in a cell. In certain embodiments, hybridization results in selective modulation of the amount, activity, or expression of a target Huntingtin gene or Huntingtin transcript in a cell.
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46.发明授权
公开(公告)号：EP1984499B1
公开(公告)日：2015-05-27
申请号：EP07710352.1
申请日：2007-01-27
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2320/51 , C12N2310/3527 , C12N2310/3525
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公开(公告)号：EP2850092A1
公开(公告)日：2015-03-25
申请号：EP13714164.4
申请日：2013-03-20
发明人： SETH, Punit, P. , SWAYZE, Eric, E. , HANESSIAN, Stephen , SCHROEDER, Benjamin, R. , GIACOMETTI, Robert, D. , MERNER, Bradley, L.
摘要： The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.
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公开(公告)号：EP2751270A1
公开(公告)日：2014-07-09
申请号：EP12828351.2
申请日：2012-08-29
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/351 , C12N2310/3515 , C12N2320/51 , C12N2310/3525
摘要： Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate compl in research, diagnostics, and/or therapeutics are described herein.
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49.发明公开SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF 有权SEREKTIVE ANTISENSE-VERBINDUNGEN UND IHRE VERWENDUNGEN
公开(公告)号：EP2742056A1
公开(公告)日：2014-06-18
申请号：EP12822510.9
申请日：2012-08-08
IPC分类号： C07H21/00 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/312 , C12N2310/3125 , C12N2310/315 , C12N2310/316 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/351 , C12N2320/34 , C12N2310/3525
摘要： Disclosed are oligomeric compounds which are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. The hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
摘要翻译： 本发明提供了有效的低聚化合物。 更具体地，本文提供的有间隙的寡聚化合物在间隙区域中包含至少一个修饰的核苷间键。 这种有效的低聚化合物具有一种或多种改进的性质，例如选择性，效力，改善的毒性特征和/或改善的促炎症状。 某些这样的寡聚化合物可用于与互补核酸杂交，包括但不限于细胞中的核酸。 在某些实施方案中，杂交导致调节细胞中靶核酸的量活性或表达。
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公开(公告)号：EP2019692B1
公开(公告)日：2014-06-04
申请号：EP07811878.3
申请日：2007-05-07
发明人： BHANOT, Sanjay , GEARY, Richard S. , MCKAY, Robert , MONIA, Brett, P. , SETH, Punit, P. , SIWKOWSKI, Andrew, M. , SWAYZE, Eric, E. , WANCEWICZ, Edward
IPC分类号： C12N15/113 , A61K31/712
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/3515 , C12Y203/0102 , C12N2310/3521
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