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公开(公告)号：EP1590472A2
公开(公告)日：2005-11-02
申请号：EP04701838.7
申请日：2004-01-13
IPC分类号： C12Q1/00
CPC分类号： C12N15/113 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding thyroid hormone receptor interactor 3. Methods of using these compounds for modulation of thyroid hormone receptor interactor 3 expression and for diagnosis and treatment of disease associated with expression of thyroid hormone receptor interactor 3 are provided.
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42.发明公开ANTISENSE MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 EXPRESSION 审中-公开血管内皮生长因子受体2反义调节
公开(公告)号：EP1436310A1
公开(公告)日：2004-07-14
申请号：EP02763756.0
申请日：2002-09-26
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of vascular endothelial growth factor receptor-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding vascular endothelial growth factor receptor-2. Methods of using these compounds for modulation of vascular endothelial growth factor receptor-2 expression and for treatment of diseases associated with expression of vascular endothelial growth factor receptor-2 are provided.
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公开(公告)号：EP1436307A1
公开(公告)日：2004-07-14
申请号：EP02766307.9
申请日：2002-09-19
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of NAC. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding NAC. Methods of using these compounds for modulation of NAC expression and for treatment of diseases associated with expression of NAC are provided.
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公开(公告)号：EP1252175A1
公开(公告)日：2002-10-30
申请号：EP01908740.2
申请日：2001-01-30
CPC分类号： C12N15/113 , A61K38/00 , C07B2200/11 , C07H21/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
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公开(公告)号：EP1210454A1
公开(公告)日：2002-06-05
申请号：EP00947510.4
申请日：2000-07-19
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SHP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHP-1. Methods of using these compounds for modulation of SHP-1 expression and for treatment of diseases associated with expression of SHP-1 are provided.
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46.发明公开
公开(公告)号：EP1163373A1
公开(公告)日：2001-12-19
申请号：EP99928729.5
申请日：1999-06-16
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/316 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-1. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-1 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-1 are provided.
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公开(公告)号：EP1117672A1
公开(公告)日：2001-07-25
申请号：EP99948416.5
申请日：1999-09-23
CPC分类号： C07H21/00 , C07B2200/11
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
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公开(公告)号：EP0979309A1
公开(公告)日：2000-02-16
申请号：EP98920076.1
申请日：1998-04-30
发明人： DEAN, Nicholas, M. , BENNETT, C., Frank , MONIA, Brett, P. , DRAPER, Kenneth , ANDERSON, Kevin, P. , BAKER, Brenda, F. , ECKER, David, J.
CPC分类号： C12N15/113 , C07H21/00 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3527 , C12N2310/3525 , C12N2310/3521
摘要： The present invention provides compositions and methods for the alimentary delivery of oligonucleotides in an animal, including a human. Modifications to the oligonucleotide which enhance uptake following alimentary delivery are provided.
摘要翻译： 本发明提供了用于在包括人在内的动物中食用寡核苷酸的组合物和方法。 提供了增强摄食后摄取的寡核苷酸的修饰。
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49.发明公开OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN 失效OLIGONUCLEOTIDZUSAMMENSTELLUNG和方法调节蛋白B7表达的
公开(公告)号：EP0957926A1
公开(公告)日：1999-11-24
申请号：EP97953268.0
申请日：1997-12-16
CPC分类号： C12N15/1138 , A61K31/711 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2310/3525 , C12N2310/3521
摘要： Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.
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50.发明公开COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION FOR REDUCING SEIZURE AND MODIFYING A NEURODEGENERATIVE SYNDROME 审中-公开组合物和调制DEW表达的方法用于减少神经变性综合征扣押和修改
公开(公告)号：EP2831231A1
公开(公告)日：2015-02-04
申请号：EP13767959.3
申请日：2013-03-14
CPC分类号： C12N15/113 , C07H21/02 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP- 17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
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