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41.发明授权SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS 有权国际海运联合会的SPIRO-OXINDOLVERBINDUNGEN ALS THERAPEUTISCHE MITTEL
公开(公告)号：EP2350090B1
公开(公告)日：2015-06-03
申请号：EP09740589.8
申请日：2009-10-13
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Lauren , FU, Jianmin , LANGILLE, Jonathan , LIU, Shifeng , SUN, Jianyu , SUN, Shaoyi , SVIRIDOV, Serguei , WOOD, Mark , ZENOVA, Alla , JIA, Qi , CADIEUX, Jean-Jacques , GAUTHIER, Simon, J. , DOUGLAS, Amy Frances , HSIEH, Tom , CHAKKA, Nagasree , CIKOJEVIC, Zoran
IPC分类号： C07D491/20 , C07D495/20 , C07D498/20 , C07D491/10 , C07D513/20 , A61K31/407 , A61P25/00
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
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42.发明公开N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN 审中-公开N-SUBSTITUIERTE BENZAMIDE UND IHRE VERWENDUNG IN DER SCHMERZBEHANDLUNG
公开(公告)号：EP2855428A1
公开(公告)日：2015-04-08
申请号：EP13726976.7
申请日：2013-05-21
发明人： ANDREZ, Jean-Christophe , CHOWDHURY, Sultan , DECKER, Shannon , DEHNHARDT, Christoph, Martin , FOCKEN, Thilo , GRIMWOOD, Michael, Edward , HEMEON, Ivan, William , JIA, Qi , LI, Jun , ORTWINE, Daniel, F. , SAFINA, Brian , SHENG, Tao , SUN, Shaoyi , SUTHERLIN, Daniel, P. , WILSON, Michael, Scott , ZENOVA, Alla, Yurevna
IPC分类号： C07C311/51 , C07D207/08 , C07D213/82 , C07D307/12 , A61K31/44 , A61K31/445 , A61K31/18 , A61P25/04
CPC分类号： C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
摘要： The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译： 本发明提供具有以下通式的新化合物及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，B，R1，R2，R3，R4，R5和RN具有 本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：EP2488531A1
公开(公告)日：2012-08-22
申请号：EP10771606.0
申请日：2010-10-14
发明人： CADIEUX, Jean-Jacques , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jianmin , JIA Qi , ABEL, Stefanie , EL-SAYED, Emad , HUTHMANN, Elke , ISARNO, Thomas
IPC分类号： C07D491/20
CPC分类号： C07D491/20 , C07D405/04
摘要： This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：EP1888592B1
公开(公告)日：2011-04-06
申请号：EP06740804.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , SVIRIDOV, Serguei , BAGHERZADEH, Mehran Seid , LIU, Shifeng , SUN, Jianyu
IPC分类号： C07D491/22 , C07D495/22 , A61K31/438 , A61K31/407 , A61P29/00
CPC分类号： C07D491/22 , C07D495/22
摘要： This invention is directed to spiroheterocyclic compounds of formula (I) : wherein (II) , k, j, p, Q, R1, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
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45.发明公开2-PYRROLIDONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF INFLAMMATORY CONDITIONS AND PAIN 审中-公开2-吡咯烷酮衍生物，以及它们用于炎性疼痛和治疗患有
公开(公告)号：EP1879892A2
公开(公告)日：2008-01-23
申请号：EP06758436.7
申请日：2006-04-20
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , RAINA, Vandna , LIU, Shifeng , SUN, Jianyu
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , A61K31/44
CPC分类号： C07D405/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The current invention is directed to 2-Pyrrolidone derivatives of formula (I); Due to their interaction with voltage-gated sodium channels these compounds are useful for the treatment of inflammatory conditions and pain.
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46.发明公开HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-COA DESATURASE 审中-公开杂环衍生物及其作为硬脂酰COA脱氢酶调解员
公开(公告)号：EP1799668A1
公开(公告)日：2007-06-27
申请号：EP05815320.6
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SVIRIDOV, Serguei , SUN, Shaoyi , SEID BAGHERZADEH, Mehran , RAINA, Vandna , HOU, Duanjie , CHOWDHURY, Sultan , LIU, Shifeng , KODUMURU, Vishnumurthy , CHAKKA, Nagasree
IPC分类号： C07D401/04 , C07D403/04 , A61K31/501
CPC分类号： C07D213/82 , C07D401/04 , C07D401/14 , C07D403/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1799667A1
公开(公告)日：2007-06-27
申请号：EP05812357.1
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , CHOWDHURY, Sultan , LIU, Shifeng , KODUMURU, Vishnumurthy
IPC分类号： C07D401/04
CPC分类号： C07D213/82
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where y, G, K, L, M, W, V, R2, R3, R4a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1648874A2
公开(公告)日：2006-04-26
申请号：EP04779562.0
申请日：2004-07-29
发明人： ABREO, Melwyn , CHAFEEV, Mikhail , CHAKKA, Nagasree , CHOWDHURY, Sultan , FU, Jian-Min , GSCHWEND, Heinz W. , HOLLADAY, Mark W. , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LI, Wenbao , LIU, Shifeng , RAINA, Vandna , SUN, Sengen , SUN, Shaoyi , SVIRIDOV, Serguei , TU, Chi , WINTHER, Michael D. , ZHANG, Zaihui
IPC分类号： C07D237/20 , C07D237/24 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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