公开(公告)号：EP2432505A1

公开(公告)日：2012-03-28

申请号：EP10720973.6

申请日：2010-05-17

申请人： Eden Therapeutics Inc.

发明人： DEPINHO, Ronald, A.

IPC分类号： A61K45/06 ,  A61K35/76 ,  A61K38/18 ,  A61K38/20 ,  A61P35/00

CPC分类号： A61K45/06 ,  A61K35/76 ,  A61K38/193 ,  A61K38/20 ,  A61N2005/1098 ,  C07K16/2818 ,  C12N2760/18132 ,  A61K2300/00

摘要： A method comprising administering, to a mammal, an oncolytic virus and an immunostimulatory agent. A method of treating a first tumor, a second tumor, or both in a mammal having a first tumor, comprising administering an oncolytic virus into the first tumor; and administering an immunostimulatory agent systemically to the mammal. A kit comprising an oncolytic virus, an immunostimulatory agent, and instructions for administering the oncolytic virus and the immunostimulatory agent to a mammal. A kit comprising an oncolytic virus, an immunostimulatory agent, and instructions for treating a second tumor in a mammal having a first tumor by administering an oncolytic virus into the first tumor; and administering an immunostimulatory agent systemically to the mammal. The methods optionally include administering an additional anticancer therapy.

公开(公告)号：EP2393921A1

公开(公告)日：2011-12-14

申请号：EP10705688.9

申请日：2010-02-05

申请人： Mount Sinai School of Medicine ,  Memorial Sloan-Kettering Cancer Center

发明人： ZAMARIN, Dmitriy ,  GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  FONG, Yuman

IPC分类号： C12N7/00 ,  A61K35/76 ,  C07K14/125 ,  C07K14/11

CPC分类号： C12N7/00 ,  A61K35/13 ,  A61K39/0011 ,  A61K39/17 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/18121 ,  C12N2760/18122 ,  C12N2760/18132 ,  C12N2760/18143 ,  C12N2760/18171

摘要： The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.

公开(公告)号：EP1424897A4

公开(公告)日：2009-06-17

申请号：EP02775172

申请日：2002-09-12

申请人： YISSUM RES DEV CO ,  THERAVIR MAN L P

发明人： ZAKAY-RONES ZICHRIA ,  PANET AMOS ,  IRVING CHARLES

IPC分类号： A01N43/04 ,  C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K38/16 ,  A61K39/42 ,  A61K48/00 ,  A61P35/00 ,  C07K14/125 ,  C12N5/10 ,  C12N7/00 ,  C12N7/08 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K35/768 ,  A61K48/00 ,  C12N7/00 ,  C12N2760/18122 ,  C12N2760/18132 ,  C12N2760/18164

公开(公告)号：EP1907015A4

公开(公告)日：2009-03-18

申请号：EP06774644

申请日：2006-07-12

申请人： WELLSTAT BIOLOGICS CORP

发明人： LORENCE ROBERT M ,  ROBERTS MICHAEL

IPC分类号： A61K48/00 ,  C07K5/00

CPC分类号： A61K45/06 ,  A61K31/4745 ,  A61K35/76 ,  C12N2760/18132 ,  A61K2300/00

摘要： Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.

公开(公告)号：EP1486211B1

公开(公告)日：2008-10-22

申请号：EP04017349.4

申请日：1994-04-29

申请人： Wellstat Biologics Corporation

发明人： Lorence, Robert M. ,  Reichard, Kirk W.

IPC分类号： A61K35/76

CPC分类号： C12N7/00 ,  A01K2267/0331 ,  A61K35/768 ,  A61K39/12 ,  A61K39/17 ,  C12N2760/18132 ,  C12Q1/70 ,  A61K2300/00

摘要： The invention provides compositions for treating cancer in a mammal comprising an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The invention also provides a composition for treating cancer in a mammal comprising such viruses in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, cytokine, or immunosuppressive agent.

公开(公告)号：EP1905304A2

公开(公告)日：2008-04-02

申请号：EP07016086.6

申请日：1998-10-09

申请人： Wellstat Biologics Corporation

发明人： Roberts, Michael S. ,  Lorence, Robert M. ,  Groene, William S. ,  Rabin, Harvey ,  von Borstel, Reid W.

IPC分类号： A01N63/00 ,  C12N7/00 ,  C12N7/02 ,  A61K35/76

CPC分类号： C12N7/00 ,  A61K35/768 ,  A61K38/21 ,  A61K39/42 ,  C12N2760/18132 ,  C12N2760/18151 ,  G01N33/5011 ,  G01N2500/10 ,  G01N2800/7028 ,  A61K2300/00

摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumours. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

摘要翻译： 本发明涉及能够复制并由此杀死具有IFN介导的抗病毒应答缺陷的肿瘤细胞的病毒，以及它们在治疗包括癌症和大肿瘤的肿瘤疾病中的用途。 RNA和DNA病毒在这方面很有用。 本发明还涉及用于选择，设计，纯化和使用这种病毒用于癌症治疗的方法。

公开(公告)号：EP1539230A4

公开(公告)日：2007-10-31

申请号：EP03761032

申请日：2003-05-22

申请人： WELLSTAT BIOLOGICS CORP

发明人： LORENCE ROBERT M

IPC分类号： A61K39/17 ,  A61K35/76 ,  A61K39/12

CPC分类号： A61K35/768 ,  A61K38/191 ,  A61K38/2013 ,  A61K38/21 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/241 ,  C12N7/00 ,  C12N2760/18132 ,  C12N2760/18151 ,  G01N33/5011

公开(公告)号：EP1605970A2

公开(公告)日：2005-12-21

申请号：EP04801879.0

申请日：2004-03-02

申请人： Wellstat Biologics Corporation

发明人： LORENCE, Robert, M.

IPC分类号： A61K39/17

CPC分类号： A61K35/768 ,  A01K2267/0331 ,  C12N2760/18132

摘要： A mammalian subject having a tumor is treated by a method comprising administering to the subject an amount of a Newcastle disease virus effective to treat the subject, wherein the virus is administered to the subject in one or more cycles; at least one cycle comprises administering sequentially one or more desensitization doses of the followed by one or more escalated doses of the virus to the subject; the amount of the virus in each escalated dose is higher than the amount of virus in each desensitization dose; and the first escalated dose is administered from 18 to 36 hours after the first desensitization dose.

摘要翻译： 具有肿瘤的哺乳动物受试者通过包括向受试者施用有效治疗受试者的量的新城疫病毒的方法来治疗，其中所述病毒在一个或多个周期内施用于受试者; 至少一个循环包括向受试者依次施用一次或多次脱敏剂量的后续一次或多次递增剂量的病毒; 每次递增剂量中病毒的量高于每种脱敏剂量中的病毒量; 并且在首次脱敏剂量后18-36小时施用第一次递增剂量。

公开(公告)号：EP1539230A2

公开(公告)日：2005-06-15

申请号：EP03761032.6

申请日：2003-05-22

申请人： Wellstat Biologics Corporation

发明人： LORENCE, Robert, M.

IPC分类号： A61K39/17 ,  A61K39/12

CPC分类号： A61K35/768 ,  A61K38/191 ,  A61K38/2013 ,  A61K38/21 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/241 ,  C12N7/00 ,  C12N2760/18132 ,  C12N2760/18151 ,  G01N33/5011

摘要： Two or more desensitization doses of a therapeutic virus are administered, followed by one or more escalated doses of the virus. In addition, the rate at which a therapeutic virus is administered can be controlled.

公开(公告)号：EP1486211A1

公开(公告)日：2004-12-15

申请号：EP04017349.4

申请日：1994-04-29

申请人： Wellstat Biologics Corporation

发明人： Lorence, Robert M. ,  Reichard, Kirk W.

IPC分类号： A61K35/76

CPC分类号： C12N7/00 ,  A01K2267/0331 ,  A61K35/768 ,  A61K39/12 ,  A61K39/17 ,  C12N2760/18132 ,  C12Q1/70 ,  A61K2300/00

摘要： The invention provides compositions for treating cancer in a mammal comprising an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The invention also provides use of Newcastle Disease Virus in the manufacture of medicaments for treating cancer in a mammal having a tumour.

摘要翻译： 本发明提供用于治疗哺乳动物癌症的组合物，其包含有效量的病毒，特别是新城疫病毒或其它副粘病毒。 本发明还提供了新城疫病毒在制造用于治疗具有肿瘤的哺乳动物中的癌症的药物中的用途。