公开(公告)号：EP2857837A4

公开(公告)日：2016-01-27

申请号：EP13798097

申请日：2013-05-31

申请人： SD BIOSENSOR INC

发明人： CHOI HYOUNG GIL ,  HONG SUNG YUB ,  HWANG HEE YOUNG ,  LEE HYO KEUN

IPC分类号： G01N33/558 ,  G01N33/532

CPC分类号： G01N33/5436 ,  G01N33/49 ,  G01N33/532 ,  G01N33/538 ,  G01N33/558 ,  G01N33/723 ,  G01N33/90

摘要： The present invention relates to a freeze-dried conjugate structure for immunochromatography, an immunoassay kit comprising the freeze-dried conjugate structure and an immunochromatographic strip, and a method for qualitatively or quantitatively analyzing an analyte in a sample using the immunoassay kit. Because a sample is subjected to immunochromatography after reacting uniformly with a freeze-dried conjugate structure separately prepared according to the present invention externally, quantitative analysis can be performed with high reproducibility and linearity depending on a concentration compared to a conventional assay method which is performed using an immunochromatographic strip comprising a conjugate pad prepared by adsorbing a conjugate. In addition, the freeze-dried conjugate structure of the present invention can be provided in a state in which it is received in a chamber additionally comprising a cap. Thus, it can be stored without contamination and is easy to carry. In addition, the freeze-dried conjugate structure can be rapidly and uniformly dissolved so that it is immediately allowed to react with a mixture of a buffer and a sample and the reaction product can be analyzed by an immunoassay kit. Thus, it is suitable for use in point-of-care testing.

公开(公告)号：EP2856941A1

公开(公告)日：2015-04-08

申请号：EP13004747.5

申请日：2013-10-01

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Moissl, Ulrich ,  Nier, Volker ,  Chamney, Paul ,  Wabel, Peter

IPC分类号： A61B5/145 ,  A61K33/26 ,  G01N33/90 ,  A61B5/02 ,  A61B5/053

CPC分类号： A61M1/3403 ,  A61B5/02042 ,  A61B5/0537 ,  A61B5/14546 ,  A61B5/4839 ,  A61B5/4866 ,  A61B5/7246 ,  A61K33/26 ,  A61M1/3413 ,  G01N33/90 ,  G01N2333/805

摘要： The present invention relates to a method for determining or approximating a patient's daily loss of iron (fe_loss), the method comprising the steps determining the patient's iron uptake (fe_uptake); determining the quantity of iron stored within the patient's body; and determining the patient's daily loss of iron based on the patient's iron uptake (fe_uptake) and the quantity of non-functional iron stored within the patient's body. The method relates further to apparatuses and an erythropoesis stimulating medicament for use in the treatment of anaemia. Finally the present invention relates to digital storage means, a computer program product, and a computer program.

摘要翻译： 本发明涉及一种用于采矿确定性或近似患者的日常铁（fe_loss）的损失的方法，该方法包括以下步骤确定性采矿患者的铁的摄取（fe_uptake）; 确定性的挖掘存储在患者体内铁的数量; 以及基于所述患者的铁的摄取（fe_uptake）和存储在所述患者的身体内的非功能性铁的量的铁的确定性采矿患者的日常损失。 该方法进一步涉及装置和用于之造血在贫血的治疗中的用途刺激药物。 最后，本发明涉及数字存储装置中，一种计算机程序产品，以及一种计算机程序。

公开(公告)号：EP2303918A4

公开(公告)日：2012-08-15

申请号：EP09770573

申请日：2009-06-26

申请人： ACCELERON PHARMA INC

发明人： SHERMAN MATTHEW L ,  BORGSTEIN NIELS

IPC分类号： A61K39/395 ,  A61K38/16 ,  C12Q1/02 ,  G01N33/20 ,  G01N33/72

CPC分类号： A61K38/1796 ,  A61K38/22 ,  C07K14/475 ,  C07K14/72 ,  C07K2319/30 ,  G01N33/721 ,  G01N33/80 ,  G01N33/90 ,  G01N2333/47 ,  G01N2333/79 ,  G01N2800/52

摘要： In certain aspects, the present invention provides methods for dosing a patient with an activin-ActRIIa antagonist and methods for managing patients treated with an activin-ActRIIa anatagonist. In certain aspects, the methods involve measuring one or more hematologic parameters in a patient.

摘要翻译： anatagonist在某些方面，本发明提供了用于在激活素-ActRIIa拮抗剂给药与患者和方法用于管理与在激活素-ActRIIa治疗患者的方法。 在某些方面，该方法包括测量患者的一个或多个血液学参数。

公开(公告)号：EP1926998B1

公开(公告)日：2010-12-29

申请号：EP06825086.9

申请日：2006-09-22

申请人： Beckman Coulter, Inc.

发明人： SIMON-LOPEZ, Ramon

IPC分类号： G01N33/49 ,  G01N33/80 ,  G01N33/72

CPC分类号： G01N33/90 ,  G01N15/12 ,  G01N33/721 ,  G01N2015/0069 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1062 ,  G01N2015/1093 ,  Y10T436/11

摘要： New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSfi defined by the formula of (MCV x MRV)1/2, or RSf2 defined by the formula of (MCV x MRV)/100, a volume-hemoglobin factor (VHf) defined by the formula of (MCV x Hgb)/100, and a volume-hemoglobin/distribution factor (VHDWf) defined by the formula of (MCV x Hgb)/(RDW x 10). Further disclosed are the methods of using these parameters for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency. Also disclosed is a method of using RSf for detection of hemochromatosis.

公开(公告)号：EP2247618A1

公开(公告)日：2010-11-10

申请号：EP09704066.1

申请日：2009-01-23

申请人： Amgen, Inc

发明人： ARVEDSON, Tara ,  DYAS, Gregory ,  ROTTMAN, James ,  SASU, Barbra

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P7/06 ,  G01N33/577

CPC分类号： C07K16/28 ,  A61K38/1816 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/76 ,  G01N33/6872 ,  G01N33/90 ,  G01N2800/00

摘要： Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

公开(公告)号：EP1259827B1

公开(公告)日：2009-10-14

申请号：EP01913026.9

申请日：2001-02-26

申请人： BIO-RAD LABORATORIES, INC.

发明人： TOBLESKY, Kristen ,  KANG, Douglas ,  EBRAHIM, Alireza ,  VANDERSLICE, Eric

IPC分类号： G01N33/90 ,  G01N33/68

CPC分类号： C12Q1/34 ,  G01N33/90 ,  G01N2333/79 ,  G01N2333/924

摘要： References, i.e. , solutions of known concentration for use as controls, calibrators, or standards, for assays of carbohydrate-deficient transferrin in bodily fluids are obtained from units of bodily fluids from normal healthy individuals by digesting the transferrin in these units with exogenous neuraminidase to achieve concentrated CDT solutions, which are then added in preselected proportions to a base matrix to achieve target concentrations.

公开(公告)号：EP1909106A2

公开(公告)日：2008-04-09

申请号：EP07023170.9

申请日：2002-09-12

申请人： F.HOFFMANN-LA ROCHE AG ,  Roche Diagnostics GmbH

发明人： Thomas, Lothar ,  Lehmann, Paul ,  Röddiger, Ralf

IPC分类号： G01N33/90

CPC分类号： G01N33/90 ,  G01N2800/52

摘要： The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron metabolism and to recommend the required treatment and to monitor the progress and response to treatment.

摘要翻译： 本发明涉及用于通过来检测三个独立参数铁代谢铁代谢紊乱的鉴别诊断的并且特别障碍的方法。 鉴别诊断可用于分类铁代谢紊乱并建议所要求的治疗并监测的进展和对治疗的反应。

公开(公告)号：EP1247101B1

公开(公告)日：2004-11-24

申请号：EP00981475.7

申请日：2000-12-11

申请人： AXIS-SHIELD ASA

发明人： SUNDREHAGEN, Erling ,  HUSA, Asgeir ,  EILERTSEN, Ingar

IPC分类号： G01N33/68

CPC分类号： G01N33/90 ,  G01N2333/79 ,  Y10S436/808 ,  Y10S436/811

公开(公告)号：EP1259827A2

公开(公告)日：2002-11-27

申请号：EP01913026.9

申请日：2001-02-26

申请人： BIO-RAD LABORATORIES, INC.

发明人： TOBLESKY, Kristen ,  KANG, Douglas ,  EBRAHIM, Alireza ,  VANDERSLICE, Eric

IPC分类号： G01N33/90 ,  G01N33/68

CPC分类号： C12Q1/34 ,  G01N33/90 ,  G01N2333/79 ,  G01N2333/924

摘要： References, i.e., solutions of known concentration for use as controls, calibrators, or standards, for assays of carbohydrate-deficient transferrin in bodily fluids are obtained from units of bodily fluids from normal healthy individuals by digesting the transferrin in these units with exogenous neuraminidase to achieve concentrated CDT solutions, which are then added in preselected proportions to a base matrix to achieve target concentrations.

公开(公告)号：EP1152888A1

公开(公告)日：2001-11-14

申请号：EP00905670.6

申请日：2000-01-19

申请人： Reference Diagnostics, Inc.

发明人： LAWLOR, Joseph, F. ,  SIEK, Gordon, C. ,  MUSTO, Joseph, D.

IPC分类号： B32B5/16 ,  C02F1/42 ,  C02F1/48 ,  C02F1/60 ,  C02F1/64 ,  G01N33/552 ,  G01N33/553

CPC分类号： B01J20/28047 ,  B01J20/08 ,  B01J20/103 ,  B01J20/26 ,  B01J20/28009 ,  B01J20/28016 ,  B01J20/28069 ,  G01N33/5434 ,  G01N33/551 ,  G01N33/90

摘要： Gel particles, methods of preparing gel particles, and methods of using gel particles are disclosed. The gel particles contain a magnetically responsive particle, and optionally a scavenger.