公开(公告)号：EP3117217A1

公开(公告)日：2017-01-18

申请号：EP15716745.3

申请日：2015-03-10

申请人： Università Degli Studi Di Verona

发明人： DE PALO, Elio Franco ,  TAGLIARO, Franco ,  SORIO, Daniela ,  BORTOLOTTI, Federica

IPC分类号： G01N33/58 ,  G01N33/68 ,  G01N33/90

CPC分类号： G01N33/6893 ,  G01N33/582 ,  G01N33/90 ,  G01N2333/79

摘要： The present invention refers to an analytical method for the identification of at least one transferrin glycoform and/ or isoform and/ or sialoform, and in particular of those known as carbohydrate-deficient transferrin, possibly present in a complex biological matrix, by protein functionalisation with a source of lanthanide 3+ ion. The marked glycoforms thus obtained may be separated and detected by fluorescence, using analytical techniques, for example, HPLC or CE.

摘要翻译： 本发明涉及用于通过蛋白质官能化鉴定至少一种转铁蛋白糖型和/或同种型和/或唾液酸，特别是鉴定可能存在于复杂生物基质中的那些已知为碳水化合物缺乏的转铁蛋白的分析方法， 镧系元素3+离子源。 通过使用分析技术，例如HPLC或CE，可以通过荧光分离并检测由此获得的标记的糖形式。

公开(公告)号：EP2910607A4

公开(公告)日：2016-06-15

申请号：EP13846619

申请日：2013-10-15

申请人： WAKO PURE CHEM IND LTD

发明人： FUJITA YOSHIKAZU ,  OHASHI TOSHINARI ,  YAMAMOTO NAOYUKI ,  TAKAGAKI TAKASHI ,  HASABA SATOSHI

IPC分类号： C09B11/28 ,  G01N31/00 ,  G01N31/22 ,  G01N33/52 ,  G01N33/84

CPC分类号： G01N33/84 ,  C09B11/24 ,  C09B11/28 ,  C09B49/12 ,  G01N31/00 ,  G01N31/22 ,  G01N33/20 ,  G01N33/90

公开(公告)号：EP2822454A2

公开(公告)日：2015-01-14

申请号：EP13757232.7

申请日：2013-03-07

申请人： BASF SE

发明人： WALK, Tilmann B. ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WIEMER, Jan, C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  PROKOUDINE, Alexandre

IPC分类号： A61B5/00 ,  A61B19/00

CPC分类号： G01N33/492 ,  G01N33/90 ,  G01N2500/04

摘要： The present invention pertains to the field of diagnostics for iron adsorption disorder or impaired energy metabolism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing iron adsorption disorder or impaired energy metabolism. It also relates to a method for determining whether a compound is capable of inducing such iron adsorption disorder or impaired energy metabolism in a subject and to a method of identifying a drug for treating iron adsorption disorder or impaired energy metabolism. Furthermore, the present invention relates to a device and a kit for diagnosing iron adsorption disorder or impaired energy metabolism.

公开(公告)号：EP2803675A3

公开(公告)日：2014-12-24

申请号：EP14171560.7

申请日：2009-01-23

申请人： Amgen, Inc

发明人： Arvedson, Tara

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P7/06 ,  G01N33/577

CPC分类号： C07K16/28 ,  A61K38/1816 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/76 ,  G01N33/6872 ,  G01N33/90 ,  G01N2800/00

摘要： Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

公开(公告)号：EP2803675A2

公开(公告)日：2014-11-19

申请号：EP14171560.7

申请日：2009-01-23

申请人： Amgen, Inc

发明人： Arvedson, Tara

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P7/06 ,  G01N33/577

CPC分类号： C07K16/28 ,  A61K38/1816 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/76 ,  G01N33/6872 ,  G01N33/90 ,  G01N2800/00

摘要： Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

摘要翻译： 提供了用于治疗铁体内平衡失调的组合物。 更具体地说，提供了抗铁转运蛋白抗体，含有这些抗体的组合物，相应的核酸，载体和宿主细胞，以及制备这种抗体的方法。

公开(公告)号：EP1425589B1

公开(公告)日：2007-12-05

申请号：EP02777081.7

申请日：2002-09-12

申请人： F. HOFFMANN-LA ROCHE AG ,  Roche Diagnostics GmbH

发明人： RÖDDIGER, Ralf ,  LEHMANN, Paul ,  THOMAS, Lothar

IPC分类号： G01N33/84

CPC分类号： G01N33/80 ,  G01N33/90 ,  G01N2800/52 ,  Y10T436/10

摘要： The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron metabolism and to recommend the required treatment and to monitor the progress and response to treatment.

公开(公告)号：EP0926499A4

公开(公告)日：2000-08-16

申请号：EP97933000

申请日：1997-07-24

申请人： SHIONOGI & CO

发明人： FUKUNAGA TAKAHIRO

IPC分类号： G01N33/68 ,  G01N33/90 ,  G01N33/53 ,  G01N33/531

CPC分类号： G01N33/90 ,  G01N33/6872 ,  G01N2333/79

摘要： The present invention relates to a method for preventing the adsorption of lactoferrin to a storage container or a reaction container characterized by regulating the pH value of a lactoferrin-containing solution in the container not to exceed 4, or regulating the salt concentration of the solution, for example, at least 1.0 M in the case of NaCl or at least 0.5 M in the case of KCl; a lactoferrin containing solution which has a pH value of at most 4, a sodium chloride concentration of at least 1.0 M or a potassium chloride concentration of at least 0.5 M; and a kit for assaying lactoferrin which comprises the above-mentioned solution as a constituting reagent.

公开(公告)号：EP0570588A4

公开(公告)日：1994-08-17

申请号：EP92924031

申请日：1992-11-30

申请人： ORIENTAL YEAST CO LTD

发明人： HAMASAKI HOZUMI - KASUGA -CHOM ,  NONOBE MASATSUGU - TSUTSUJIGAO ,  FUJITA TSUYOSHI - SATSUKIGAOKA

IPC分类号： C12Q1/32 ,  C12Q1/34 ,  C12Q1/527 ,  G01N33/90

CPC分类号： C12Q1/32 ,  C12Q1/34 ,  C12Q1/527 ,  G01N33/90 ,  Y10S436/91

公开(公告)号：EP4392174A1

公开(公告)日：2024-07-03

申请号：EP22859643.3

申请日：2022-08-24

申请人： The University of Melbourne ,  The Florey Institute of Neuroscience and Mental Health

发明人： MCCOLL, Gawain ,  SIMPSON, David, Allan ,  HALL, Liam, Terres ,  GRANT, Erin, Susanne

IPC分类号： B01J3/06 ,  C03B25/02 ,  C03B33/04 ,  H01L29/66 ,  G01R33/32 ,  G01N33/50 ,  G01N33/90 ,  C03B29/04 ,  B82Y15/00 ,  G01N21/64 ,  G01N24/10 ,  H01L29/16

CPC分类号： B82Y15/00 ,  G01N24/10 ,  G01N33/90 ,  G01N21/6489 ,  G01R33/323 ,  G01N24/088 ,  G01R33/26

公开(公告)号：EP2186524B1

公开(公告)日：2018-02-21

申请号：EP09004579.0

申请日：2002-05-24

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Nicolas, Gaël ,  Vaulont, Sophie ,  Kahn, Axel

IPC分类号： A61K38/03 ,  A61K38/04 ,  A61K38/17 ,  A61P3/12

CPC分类号： A61K38/22 ,  A61K38/10 ,  A61K38/1709 ,  G01N33/90

摘要： The invention concerns the use of hepcidin for the diagnosis and therapy of disorders of iron homeostasis. Hepcidin can be used in the treatment of disorders resulting from iron overload, while inhibitors of hepcidin can be used in the treatment of anaemia.