公开(公告)号：EP2755976B1

公开(公告)日：2018-07-18

申请号：EP12769172.3

申请日：2012-09-13

申请人： Novartis AG

发明人： CHEN, Chao ,  DENG, Haibing ,  GUO, Haibing ,  HE, Feng ,  JIANG, Lei ,  LIANG, Fang ,  MI, Yuan ,  WAN, Huixin ,  XU, Yao-Chang ,  YU, Hongping ,  ZHANG, Ji Yue (Jeff)

IPC分类号： A61K45/06 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  C07D491/107 ,  C07D471/04 ,  C07D519/00 ,  A61K31/437

CPC分类号： A61K31/551 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D471/04 ,  C07D491/107 ,  C07D519/00

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

公开(公告)号：EP2720699B1

公开(公告)日：2018-05-16

申请号：EP12801372.9

申请日：2012-06-13

申请人： Hale BioPharma Ventures, LLC

发明人： CARTT, Steve ,  MEDEIROS, David ,  GWOZDZ, Garry, Thomas ,  LOXLEY, Andrew ,  MITCHNICK, Mark ,  HALE, David ,  MAGGIO, Edward, T.

IPC分类号： A61K9/08 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K31/5513 ,  A61K31/355 ,  A61K45/06 ,  A61P25/08

CPC分类号： A61K9/0043 ,  A61K9/008 ,  A61K9/08 ,  A61K9/10 ,  A61K31/355 ,  A61K31/5513 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K2300/00

摘要： The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.

公开(公告)号：EP2817310B1

公开(公告)日：2018-03-21

申请号：EP13700849.6

申请日：2013-01-22

申请人： Merck Patent GmbH

发明人： DEUTSCH, Carl ,  KUHN, Daniel ,  ROSS,Tatjana ,  BURGDORF, Lars

IPC分类号： A61K31/496 ,  A61K31/519 ,  A61K31/537 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/5513 ,  C07D487/04 ,  C07D519/00 ,  A61K31/5386

CPC分类号： C07D487/04 ,  A61K31/496 ,  A61K31/519 ,  A61K31/537 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/5513 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411

摘要： Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus.

公开(公告)号：EP3166637A4

公开(公告)日：2018-03-14

申请号：EP15818675

申请日：2015-07-07

申请人： THE J DAVID GLADSTONE INST ,  UNIV CALIFORNIA

发明人： OTT MELANIE ,  KONDRATOWICZ ANDREW S ,  KROGAN NEVAN JOHN ,  SHAH PRIYA SHIRISH ,  FONTAINE KRYSTAL ANN

IPC分类号： A61K39/42 ,  A61K31/18 ,  A61K31/381 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  A61P31/14

CPC分类号： A61K31/5513 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/18 ,  A61K31/381 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61P31/14

摘要： The present disclosure provides methods of treating a flavivirus infection, and compositions for use in the methods.

公开(公告)号：EP3182986A4

公开(公告)日：2018-01-24

申请号：EP15833324

申请日：2015-08-20

申请人： PROFESSIONAL COMPOUNDING CENTERS OF AMERICA (PCCA)

发明人： BANOV DANIEL

IPC分类号： A61K36/48 ,  A61K9/00 ,  A61K31/09 ,  A61K31/135 ,  A61K31/167 ,  A61K31/197 ,  A61K31/4174 ,  A61K31/4745 ,  A61K31/5513 ,  A61K31/565 ,  A61K31/568 ,  A61K31/58 ,  A61K35/00 ,  A61K47/36 ,  A61P1/04 ,  A61P15/02

CPC分类号： A61K47/36 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/006 ,  A61K31/09 ,  A61K31/135 ,  A61K31/167 ,  A61K31/197 ,  A61K31/4174 ,  A61K31/4745 ,  A61K31/5513 ,  A61K31/565 ,  A61K31/568 ,  A61K31/58 ,  A61K35/00 ,  A61K2300/00

摘要： Excipient compositions including a combination of excipients for mucoadhesive pharmaceutical compositions that improve mucoadhesiveness power, as well as release of and adhesion time of suitable active pharmaceutical ingredients (APIs) are disclosed. The excipient compositions include an aqueous solution with a synergistic combination of polymers, such as, for example amylopectin, pullulan, hyaluronic acid, and tamarind xyloglucan, among others. These polymers have been demonstrated to improve the release of as well as the adhesion time of APIs onto mucosa membrane. Mucoadhesive pharmaceutical compositions that include excipient compositions include suitable APIs, such as, for example analgesics, anesthetics, anthelmintics, anti-allergic agents, anti-fungals, antihistamines, anti-inflammatory agents, antimigraine agents, and hormones, among others. Mucoadhesive pharmaceutical compositions including excipient compositions are employed in the treatment of a plurality of mucous membrane diseases.

公开(公告)号：EP3177626A4

公开(公告)日：2017-12-27

申请号：EP15830298

申请日：2015-08-07

申请人： DANA FARBER CANCER INST INC

发明人： BRADNER JAMES E ,  BUCKLEY DENNIS

IPC分类号： C07D487/04 ,  A61K31/5513 ,  A61P35/00 ,  C07D243/06

CPC分类号： C07D487/04

摘要： The present disclosure provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) have been found to bind bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, neurological diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

公开(公告)号：EP2588112B1

公开(公告)日：2017-09-27

申请号：EP11810107.0

申请日：2011-06-28

申请人： Victoria Link Ltd

发明人： LAFLAMME, Anne, Camille ,  CONNOR, Bronwen, Jane ,  O'SULLIVAN, David

IPC分类号： A61K31/5513 ,  A61K31/551 ,  A61K31/55 ,  A61K31/519 ,  A61K31/4178 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K31/519 ,  A61K31/4178 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61K2300/00

公开(公告)号：EP3189056A1

公开(公告)日：2017-07-12

申请号：EP15763739.8

申请日：2015-09-02

申请人： ImmunoGen, Inc.

发明人： CHARI, Ravi V.J. ,  MILLER, Michael Louis ,  SHIZUKA, Manami

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5513 ,  A61P35/00 ,  C07K16/28 ,  C07K7/02

CPC分类号： A61K47/64 ,  A61K2039/505 ,  C07D487/04 ,  C07D519/00 ,  C07K5/0202 ,  C07K5/0819 ,  C07K5/1021 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/92

摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

摘要翻译： 本发明涉及具有抗增殖活性的新型苯并二氮杂衍生物，并且更具体地涉及式（I） - （VI）的新型苯并二氮杂化合物。 本发明还提供连接至细胞结合剂的苯并二氮杂化合物的缀合物。 本发明进一步提供了可用于使用本发明的化合物或缀合物抑制异常细胞生长或治疗哺乳动物增殖性病症的组合物和方法。

公开(公告)号：EP2681206B1

公开(公告)日：2017-06-14

申请号：EP12709439.9

申请日：2012-03-02

申请人： Lexicon Pharmaceuticals, Inc.

发明人： AUGERI, David John ,  BAGDANOFF, Jeffrey Thomas ,  BAUGH, Simon David Peter ,  CARLSEN, Marianne ,  CARSON, Kenneth Gordon ,  GILLERAN, John Anthony ,  HE, Wei ,  ORAVECZ, Tamas ,  SALOJIN, Konstantin ,  SUNG, Leonard

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  A61K31/4418 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/5513 ,  A61K31/553 ,  A61P29/00

CPC分类号： C07D401/04 ,  A61K31/4365 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：EP3049087A4

公开(公告)日：2017-05-24

申请号：EP14847914

申请日：2014-09-26

申请人： AUSPEX PHARMACEUTICALS INC

发明人： ZHANG CHENGZHI

IPC分类号： A61K31/5513 ,  A61K31/551 ,  A61P25/14 ,  C07D455/06

CPC分类号： C07D471/04 ,  A61K31/473 ,  A61K31/4745 ,  A61K45/06 ,  C07D455/06 ,  A61K2300/00