公开(公告)号：EP3247707A1

公开(公告)日：2017-11-29

申请号：EP16702652.5

申请日：2016-01-21

申请人： Myokardia, Inc.

发明人： OSLOB, Johan ,  AUBELE, Danielle ,  KIM, Jae ,  MCDOWELL, Robert ,  SONG, Yonghong ,  SRAN, Arvinder ,  ZHONG, Min

IPC分类号： C07D401/14 ,  C07D401/02 ,  C07D407/02 ,  C07D407/14 ,  C07D409/02 ,  C07D411/14 ,  C07D471/04 ,  A61K31/435 ,  A61P9/04

CPC分类号： A61K31/4545 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D401/02 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/02 ,  C07D407/14 ,  C07D409/02 ,  C07D411/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

公开(公告)号：EP3042900A1

公开(公告)日：2016-07-13

申请号：EP14840352.0

申请日：2014-08-27

申请人： Fujifilm Corporation

发明人： KUBO, Yohei ,  ANDO, Makoto ,  TANAKA, Hidehiko ,  OSAKA, Shuhei ,  MATSUMOTO, Takuya ,  NAKATA, Hiyoku ,  TERADA, Daisuke ,  NITABARU, Tatsuya

IPC分类号： C07D401/14 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61P31/14 ,  A61P35/00 ,  A61P43/00 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D411/04 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14 ,  C07D491/048 ,  C07D491/052

摘要： There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof.

(In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z 2 represents CH or the like; Z 1 represents CR 6 or the like; R 6 represents a hydrogen atom or the like; X 1 represents CHR 7 or the like; R 7 represents a hydrogen atom or the like; X 2 represents CH 2 or the like; R 1 and R 2 are the same as or different from each other, and each of R 1 and R 2 represents a hydrogen atom or the like; R 3 , R 4 and R 5 are the same as or different from each other, and each of R 3 , R 4 , and R 5 represents a hydrogen atom, NR a R b , or the like; and each of R a and R b represents a hydrogen atom, a C 1-8 alkyl group which may have a substituent, or the like.)

公开(公告)号：EP3022199A1

公开(公告)日：2016-05-25

申请号：EP14748306.9

申请日：2014-07-16

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： SATO, Seiji ,  MATSUDA, Satoshi ,  MATSUMURA, Chiharu ,  ITOTANI, Motohiro ,  SHINOHARA, Toshio ,  FUJITA, Shigekazu ,  SAKURAI, Yohji ,  TAI, Kuninori ,  FUKUSHIMA, Tae ,  KANEMOTO, Naohide ,  OKAMOTO, Takashi

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D411/12 ,  C07D411/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D249/04 ,  C07D249/06 ,  A61K31/4192

CPC分类号： C07D249/06 ,  C07D249/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D411/12 ,  C07D411/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07F9/5456

摘要： This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.

摘要翻译： 本发明涉及由式（1）表示的氰基三唑化合物或其盐，其中每个符号在说明书中定义。 该化合物或其盐可以刺激柠檬酸循环活性和/或改善高血糖症，副作用少，安全性优异，因此可用于治疗和/或预防柠檬酸循环活性化和/或预防 高血糖的改善具有预防和/或治疗效果，例如糖尿病，葡萄糖耐量降低，胰岛素抵抗，糖尿病并发症，肥胖症，血脂异常，肝脂肪变性，动脉粥样硬化和/或心血管疾病以及有益于的疾病或病症 从刺激能源开支。

公开(公告)号：EP2588451B1

公开(公告)日：2015-12-30

申请号：EP11730270.3

申请日：2011-06-30

申请人： Boehringer Ingelheim International GmbH

发明人： ROTH, Gerald Juergen ,  FLECK, Martin ,  LEHMANN-LINTZ, Thorsten ,  NEUBAUER, Heike ,  NOSSE, Bernd

IPC分类号： C07D211/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D411/04 ,  C07D411/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

CPC分类号： C07D211/34 ,  A61K45/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D411/04 ,  C07D411/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

公开(公告)号：EP2445904B1

公开(公告)日：2013-09-11

申请号：EP10747954.5

申请日：2010-06-17

申请人： Cadila Healthcare Limited

发明人： PINGALI, Harikishore ,  ZAWARE, Pandurang ,  JAIN, Mukul

IPC分类号： C07D411/12 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/506

CPC分类号： C07D411/12 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2588451A1

公开(公告)日：2013-05-08

申请号：EP11730270.3

申请日：2011-06-30

申请人： Boehringer Ingelheim International GmbH

发明人： ROTH, Gerald Juergen ,  FLECK, Martin ,  LEHMANN-LINTZ, Thorsten ,  NEUBAUER, Heike ,  NOSSE, Bernd

IPC分类号： C07D211/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D411/04 ,  C07D411/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

CPC分类号： C07D211/34 ,  A61K45/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D411/04 ,  C07D411/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

摘要： The invention relates to new piperidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

公开(公告)号：EP2352730A2

公开(公告)日：2011-08-10

申请号：EP09825277.8

申请日：2009-11-02

申请人： H. Lundbeck A/S

发明人： PETERSON, John ,  CHEN, Chien-an ,  CHEN, Bin ,  WU, Lingyun ,  SABIO, Michael

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D411/14 ,  C07D413/14 ,  A61K31/4427 ,  A61P3/00 ,  A61P3/04

CPC分类号： C07D401/12 ,  A61K31/4427 ,  C07D211/40 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/048 ,  C07D513/04

摘要： The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from certain disorders which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from certain disorders.

公开(公告)号：EP2167484A2

公开(公告)日：2010-03-31

申请号：EP08784753.9

申请日：2008-07-14

申请人： Syngenta Participations AG

发明人： HALL, Roger Graham ,  LOISELEUR, Olivier ,  PABBA, Jagadish ,  PAL, Sitaram ,  JEANGUENAT, André ,  EDMUNDS, Andrew ,  STOLLER, André

IPC分类号： C07D317/68 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/12 ,  A01N43/56

CPC分类号： C07D317/68 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D411/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/12

摘要： An insecticidal compound of formula (I) in which G1, G2, and G3 together with the two carbon atoms to which G1 and G3 are attached, form a non-aromatic 4- or 5-membered ring system; wherein G1 is sulfur, SO, SO2, oxygen, a direct bond, NRa or CR5aR5b; G2 is sulfur, SO, SO2, oxygen, a direct bond, NRb or CR5cR5d; G3 is sulfur, SO, SO2, oxygen, a direct bond, NRc or CR5eR5f; with the provisos that a) not more than 1 group G can be a direct bond, b) not more than 2 G groups can be oxygen, sulfur, SO or SO2 and c) when 2 G groups are oxygen, SO, SO2 and/or sulfur the two groups are separated by a carbon atom; each of Z1 and Z2, which may be the same or different, represents oxygen or sulfur; D is phenyl or a 5- or 6-membered heteroaromatic ring and R1a, R1b, R5a, R5b, R5c, R5d, R5e, R5f, Ra, Rb Rc, R2, R3 and R20 are specified organic groups and agronomically acceptable salts/isomers/enantiomers/tautomers/N-oxides of those compounds.

公开(公告)号：EP1399441A1

公开(公告)日：2004-03-24

申请号：EP02754750.4

申请日：2002-06-25

申请人： SMITHKLINE BEECHAM PLC

发明人： BRANCH, Clive, Leslie,GlaxoSmithKline ,  CHAN, Wai, Ngor,GlaxoSmithKline ,  JOHNS, Amanda,GlaxoSmithKline ,  JOHNSON, Christopher, Norbert,GlaxoSmithKline ,  NASH, David, John,GlaxoSmithKline ,  NOVELLI, Riccardo,GlaxoSmithKline ,  PILLEUX, Jean-Pierre,GlaxoSmithKline ,  PORTER, Roderick, Alan,GlaxoSmithKline ,  STEAD, Rachel, Elizabeth, Anne,GlaxoSmithKline ,  STEMP, Geoffrey,GlaxoSmithKline

IPC分类号： C07D417/14 ,  C07D411/14 ,  C07D407/14 ,  C07D413/14 ,  A61K31/445 ,  A61P25/00 ,  A61P3/10 ,  A61P15/00 ,  C07D407/06 ,  C07D491/04 ,  C07D401/06 ,  C07D409/14 ,  C07D471/04

CPC分类号： C07D417/14 ,  C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D491/04

摘要： This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen , NR3 or a group (CH¿2?), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar?2¿ represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.

公开(公告)号：EP1343779A4

公开(公告)日：2004-01-28

申请号：EP01986007

申请日：2001-11-20

申请人： SMITHKLINE BEECHAM CORP

发明人： ADAMS JERRY L ,  BRYAN DEBORAH L

IPC分类号： A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P27/02 ,  A61P35/00 ,  A61P35/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D411/14 ,  A61K31/44

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14