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472 条记录 (耗时 0.022 秒)

    Process for the depolymerization of glycosaminoglycanes and products obtained therefrom
    45.
    发明公开
    Process for the depolymerization of glycosaminoglycanes and products obtained therefrom 审中-公开
    Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte

    公开(公告)号：EP1344781A1

    公开(公告)日：2003-09-17

    申请号：EP02425142.3

    申请日：2002-03-12

    申请人： LABORATORI DERIVATI ORGANICI S.P.A.

    发明人： Gonella, Sergio ,  De Ambrosi, Luigi ,  Vismara, Elena

    IPC分类号： C08B37/08 ,  C08B37/10

    CPC分类号： C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0078

    摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid.
    The invention also relates to intermediate depolymerized heparin having Mw comprised between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio SO 3 - /COO - equal to or higher than in the starting heparin.
    The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.

    摘要翻译： 本发明涉及一种用于解聚糖胺聚糖的方法，其特征在于在选自醚，醇，醛，酰胺和甲酸的有机化合物存在下使用高能辐射。 本发明还涉及Mw在1000-5500之间的中等解聚的肝素，在400nm以下的吸光度低于0.300，SO 3 - / COO - 的比例等于或高于起始肝素。 中间解聚的肝素可以溶解在缓冲溶液中，并通过凝胶渗透分级分离得到所需的分子量。

    NEW PROCESS FOR PREPARING SURFACE MODIFICATION SUBSTANCES
    47.
    发明公开
    NEW PROCESS FOR PREPARING SURFACE MODIFICATION SUBSTANCES 有权
    新工艺用于生产表面处理机构

    公开(公告)号：EP1112097A1

    公开(公告)日：2001-07-04

    申请号：EP99944936.6

    申请日：1999-09-08

    申请人： NORSK HYDRO ASA

    发明人： SCHOLANDER, Elisabeth

    IPC分类号： A61L33/00 ,  C08B37/10

    CPC分类号： C08B37/0075 ,  A61L33/0029

    摘要： The present invention relates to a process for preparing surface modifications having an improved antithrombogenic activity, whereby the improvement is achieved by treating heparin at elevated temperature or at elevated pH or in contact with nucleophilic catalysts such as amines, alcohols, thiols or immobilized amino, hydroxyl or thiol groups before attaching said heparin to the surface to be modified.

    COMPOSITIONS FOR THE REGULATION OF CYTOKINE ACTIVITY
    48.
    发明授权
    COMPOSITIONS FOR THE REGULATION OF CYTOKINE ACTIVITY 失效
    组合物用于调节细胞因子

    公开(公告)号：EP0669827B1

    公开(公告)日：2001-05-23

    申请号：EP94901394.0

    申请日：1993-11-09

    申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    发明人： COHEN, Irun R. ,  LIDER, Ofer ,  CAHALON, Liora ,  SHOSEYOV, Oded ,  MARGALIT, Raanan

    IPC分类号： A61K31/715 ,  C08B37/10 ,  A61K31/70 ,  C07H11/00

    CPC分类号： A61K31/7024 ,  A61K31/70 ,  A61K31/7016 ,  C07H11/00

    摘要： Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secretion of Tumor Necrosis Factor Alpha (TNF- alpha ) can be either inhibited or augmented selectively by administration to the host of effective amounts of substances or their compositions comprising specific oligosaccharides in substantially purified form. Thus, the present invention also relates to pharmaceutical compositions and their use for the prevention and/or treatment of pathological processes involving the induction of active cytokine secretion, such as TNF- alpha . The invention also relates to the initiation of a desirable immune system-related response by the host to the presence of activators, including pathogens. The substances and pharmaceutical compositions of the present invention may be daily, at very low effective doses, typically below 0.1 mg/kg human, or at intervals of up to about 5-8 days, preferably once a week.

    A heparin complex and medical device having such substance
    49.
    发明公开
    A heparin complex and medical device having such substance 失效
    肝素复合物和医疗器械包含化合物，例如

    公开(公告)号：EP0769503A3

    公开(公告)日：1997-10-08

    申请号：EP96402220.6

    申请日：1996-10-16

    申请人： TERUMO KABUSHIKI KAISHA

    发明人： Motomura, Tadahiro, c/o Terumo K.K. ,  Anzai, Takao, c/o Terumo K.K. ,  Onishi, Makoto, c/o Terumo K.K.

    IPC分类号： C08B37/10 ,  A61L33/00

    CPC分类号： A61L33/0023 ,  C08B37/0075

    摘要： A heparin complex having anticoagulation activity and being insoluble in blood is provided. The preferred complex comprises a cationic alkyldimethylammonium represented by formula (1):
    wherein R 1 and R 2 are independently an alkyl or alkenyl group, each group is C 12 -C 24 when R 1 and R 2 are the same, the sum of the carbon atoms are 26-38 when R 1 and R 2 are different; and heparin. In this complex, reduction in the anticoagulation activity of the heparin by the formation of the complex is minimized, and ionic bonding of the heparin is quite stable. Dissolution of the cationic alkyldimethylammonium from the coating is also minimized. A medical device coated with such substance is also provided.