公开(公告)号：EP2917372A1

公开(公告)日：2015-09-16

申请号：EP13853114.0

申请日：2013-11-07

申请人： Genia Technologies, Inc.

发明人： DAVIS, Randall ,  CHEN, Roger ,  BIBILLO, Arkadiusz ,  KORENBLUM, Daniel ,  DORWART, Michael

IPC分类号： C12Q1/68 ,  G01N33/48

CPC分类号： C12Q1/6869 ,  G01N27/44717 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2527/113 ,  C12Q2535/122 ,  C12Q2563/113 ,  C12Q2565/631 ,  C12Q2537/157

摘要： This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.

公开(公告)号：EP2864502A1

公开(公告)日：2015-04-29

申请号：EP13807639.3

申请日：2013-04-08

申请人： The Trustees of Columbia University in the City of New York ,  Genia Technologies, Inc.

发明人： JU, Jingyue ,  DAVIS, Randall ,  CHEN, Roger

IPC分类号： C12Q1/68 ,  C12Q1/00

CPC分类号： C12Q1/6869 ,  G01N33/48721 ,  C12Q2521/101 ,  C12Q2521/543 ,  C12Q2537/157 ,  C12Q2565/631

摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

公开(公告)号：EP2815425A1

公开(公告)日：2014-12-24

申请号：EP12868506.2

申请日：2012-12-14

申请人： Genia Technologies, Inc.

发明人： CHEN, Roger, J. A.

IPC分类号： H01L21/302

CPC分类号： H01L23/552 ,  B82Y15/00 ,  G01N27/44756 ,  G01N27/44791 ,  G01N33/48721 ,  H01L21/76877 ,  H01L23/5225 ,  H01L23/585 ,  H01L28/60 ,  H01L2924/0002 ,  H01L2924/00

摘要： A device having an integrated noise shield is disclosed. The device includes a plurality of vertical shielding structures substantially surrounding a semiconductor device. The device further includes an opening above the semiconductor device substantially filled with a conductive fluid, wherein the plurality of vertical shielding structures and the conductive fluid shield the semiconductor device from ambient radiation. In some embodiments, the device further includes a conductive bottom shield below the semiconductor device shielding the semiconductor device from ambient radiation. In some embodiments, the opening is configured to allow a biological sample to be introduced into the semiconductor device. In some embodiments, the vertical shielding structures comprise a plurality of vias, wherein each of the plurality of vias connects more than one conductive layers together. In some embodiments, the device comprises a nanopore device, and wherein the nanopore device comprises a single cell of a nanopore array.

摘要翻译： 公开了一种具有集成噪声屏蔽的装置。 该装置包括基本围绕半导体器件的多个垂直屏蔽结构。 该装置还包括基本上填充有导电流体的半导体器件上方的开口，其中多个垂直屏蔽结构和导电流体屏蔽半导体器件免受环境辐射。 在一些实施例中，该器件还包括在半导体器件下面的导电底部屏蔽件，该半导体器件屏蔽半导体器件免受环境辐射。 在一些实施例中，开口被配置为允许将生物样品引入到半导体器件中。 在一些实施例中，垂直屏蔽结构包括多个通孔，其中多个通孔中的每一个将一个以上的导电层连接在一起。 在一些实施方案中，该装置包括纳米孔装置，并且其中纳米孔装置包括纳米孔阵列的单个细胞。

公开(公告)号：EP2814983A1

公开(公告)日：2014-12-24

申请号：EP13748712.0

申请日：2013-02-15

申请人： Genia Technologies, Inc.

发明人： DAVIS, Randall ,  CHEN, Roger

IPC分类号： C12Q1/68 ,  C12N15/11

CPC分类号： C12Q1/6869 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2310/3517 ,  C12N2320/10 ,  C12N2320/32 ,  G01N33/48721 ,  G01N33/5432 ,  C12Q2565/607 ,  C12Q2565/631

摘要： The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.

公开(公告)号：EP2668645A2

公开(公告)日：2013-12-04

申请号：EP11857055.5

申请日：2011-12-12

申请人： Genia Technologies, Inc.

发明人： CHEN, Roger

IPC分类号： G08C15/06

摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.