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    MOLECULES FOR THE TREATMENT OF LUNG DISEASE INVOLVING AN IMMUNE REACTION TO CONNECTIVE TISSUE FOUND IN THE LUNG
    51.
    发明公开
    MOLECULES FOR THE TREATMENT OF LUNG DISEASE INVOLVING AN IMMUNE REACTION TO CONNECTIVE TISSUE FOUND IN THE LUNG 有权
    键入使用胶原V的方法中的用于特发性肺纤维化的治疗

    公开(公告)号：EP1977234A1

    公开(公告)日：2008-10-08

    申请号：EP07756361.7

    申请日：2007-01-29

    申请人： Indiana University Research&technology Corporation ,  Wilkes, David S. ,  Klemsz, Michael J.

    发明人： WILKES, David, S. ,  KLEMSZ, Michael, J.

    IPC分类号： G01N33/00 ,  G01N33/566 ,  G01N33/567

    CPC分类号： G01N33/564 ,  G01N33/6887 ,  G01N2800/12

    摘要： Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one method pulmonary disease and disorders such as Idiopathic Pulmonary Fibrosis (IPF) are diagnosed by analyzing fluid or tissue samples obtained from a patient for evidence of an autoimmune response to various types of collagen including, for example, Type V. One type of assay for evidence of an autoimmune response to Type V collagen comprises the steps of obtaining a fluid or tissue sample from a patient, contacting at least a portion of the sample with antigen to anti-Type V collagen antibody and monitoring the mixture of sample and antigen for changes indicative of the presence of anti-Type V collagen in the sample. Another embodiment includes treating pulmonary diseases such as IPF by administering a therapeutically effective dose of epitopes of various collagens including Type V collagen.