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公开(公告)号：EP3705488A1
公开(公告)日：2020-09-09
申请号：EP20171670.1
申请日：2015-05-29
发明人： BOTELLA, Gabriel Martinez , HARRISON, Boyd L. , ROBICHAUD, Albert Jean , SALITURO, Francesco G. , BERESIS, Richard Thomas
摘要： Described herein is a compound of the formula:
for use in a method for treating essential tremor in a subject in need thereof comprising administering to the subject the compound. The present invention also provides a pharmaceutically acceptable salt of the compound of the present invention for use in: (i) a method for treating essential tremor in a subject in need thereof comprising administering to the subject the pharmaceutically acceptable salt of the compound or (ii) a method for treating essential tremor in a subject in need thereof comprising administering to the subject the composition.-
52.发明公开
公开(公告)号：EP3650027A1
公开(公告)日：2020-05-13
申请号：EP19195977.4
申请日：2013-01-23
发明人： REDDY, Kiran
摘要： Formulations of comprising the neuroactive steroid allopregnanolone, and a cyclodextrin, e.g., a β-cyclodextrin, preferably a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and use thereof in treating CNS disorders.
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公开(公告)号：EP2986624B1
公开(公告)日：2020-03-25
申请号：EP14786089.4
申请日：2014-04-17
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公开(公告)号：EP3377070A1
公开(公告)日：2018-09-26
申请号：EP16867267.3
申请日：2016-11-18
发明人： DOHERTY, James, J.
IPC分类号： A61K31/57 , A61K31/56 , A61K31/573
CPC分类号： A61K31/569 , A61K31/56 , A61K31/5685 , A61K31/57 , A61K31/573 , A61K31/58
摘要： Compounds, compositions, and methods for treating injuries caused by exposure to chemical warfare and similar agents are described herein.
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公开(公告)号：EP3204011A4
公开(公告)日：2018-06-20
申请号：EP15849514
申请日：2015-10-07
CPC分类号： A61K31/575 , A61K31/00 , A61K45/00 , A61K45/06 , A61K2300/00
摘要： Methods for treating a subject suffering from a sterol synthesis disorder or a sterol deficiency disorder, e.g., Smith-Lemli-Opitz syndrome, the method comprising administering to the subject an effective amount of an NMDA receptor modulating compound, are provided.
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公开(公告)号：EP3319612A1
公开(公告)日：2018-05-16
申请号：EP16821926.9
申请日：2016-07-06
发明人： SALITURO, Francesco, G. , ROBICHAUD, Albert, Jean , MARTINEZ BOTELLA, Gabriel , HARRISON, Boyd, L.
IPC分类号： A61K31/567 , A61K31/566
CPC分类号： C07J9/00 , A61P3/00 , C07J7/002 , C07J9/005 , C07J13/007 , C07J17/00 , C07J21/00 , C07J31/006 , C07J41/0061
摘要： Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, and R3 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
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公开(公告)号：EP3280420A1
公开(公告)日：2018-02-14
申请号：EP16777382.9
申请日：2016-04-08
发明人： ROBICHAUD, Albert, Jean , SALITURO, Francesco, G. , MARTINEZ BOTELLA, Gabriel , HARRISON, Boyd, L. , JONAS, Jeffrey
CPC分类号： A61K31/57 , A61K9/0019 , A61K9/0053 , A61K45/06 , A61P25/24 , C07B2200/05 , C07J7/002
摘要： Described herein are deuterium-enriched neuroactive steroids of the Formula (II) or a pharmaceutically acceptable salt thereof; wherein R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, Rlla, Rllb, R12a, R12b, R16a, R16b, R17, R19, Ra, and Rb and subvariables thereof are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment.
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公开(公告)号：EP3149018A4
公开(公告)日：2017-12-06
申请号：EP15799762
申请日：2015-05-29
发明人： BOTELLA GABRIEL MARTINEZ , HARRISON BOYD L , ROBICHAUD ALBERT JEAN , SALITURO FRANCESCO G , BERESIS RICHARD THOMAS
CPC分类号： C07J43/003 , C07J1/0022 , C07J1/0059 , C07J7/002 , C07J7/007 , C07J7/0085 , C07J13/007 , C07J21/00 , C07J31/006 , C07J71/001
摘要： Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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公开(公告)号：EP3191101A1
公开(公告)日：2017-07-19
申请号：EP15839264.7
申请日：2015-09-08
CPC分类号： A61K31/573 , A61K9/0019 , A61K9/0053 , A61K31/57 , A61K47/40
摘要： Described herein are methods of treating tremor, e.g., essential tremor; depression, e.g., postpostum depression; and anxiety disorder, the method comprising administering to a human subject suffering from tremor, e.g., essential tremor; depression, e.g., postpostum depression, an anxiety disorder with a neuroactive steroid or a composition comprising a neuroactive steroid (e.g., pregnanolone, allopregnanolone, alphadalone, ganaxolone, or alphaxolone).
摘要翻译： 本文描述了治疗震颤的方法，例如，特发性震颤; 抑郁症，例如，postpostum抑郁症; 和焦虑症，该方法包括对患有震颤例如特发性震颤的人类受试者施用; 抑郁症，例如postpostum抑郁症，具有神经活性类固醇的焦虑症或包含神经活性类固醇（例如，妊娠酮，别孕烷酮，阿法龙，加奈索酮或阿克赛龙）的组合物。
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60.发明公开NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF 审中-公开NEUROAKTIVE STEROIDE，ZUSAMMENSETZUNGEN DAMIT UND VERWENDUNGEN DAVON
公开(公告)号：EP3021852A4
公开(公告)日：2017-03-22
申请号：EP14826212
申请日：2014-07-18
CPC分类号： C07J41/0094 , A61K31/56 , A61K31/565 , A61K31/567 , A61K45/06 , C07J1/0011 , C07J1/0022 , C07J5/0053 , C07J11/00 , C07J21/008 , C07J31/006 , C07J51/00 , C07J71/001 , A61K2300/00
摘要： Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
摘要翻译： 本文描述了式（I）的神经活性甾族化合物：（式（I））或其药学上可接受的盐; 其中R 1a和R 1b如本文所定义。 在某些实施方案中，这些化合物被设想用作GABA调节剂。 本发明还提供了包含本发明化合物的药物组合物以及使用和治疗方法，例如用于诱导镇静和/或麻醉的方法。
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