公开(公告)号：EP2707102A2

公开(公告)日：2014-03-19

申请号：EP12782437.3

申请日：2012-05-09

申请人： VisEn Medical, Inc.

发明人： GROVES, Kevin ,  BAO, Bagna

IPC分类号： A61P35/00

摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

公开(公告)号：EP1833513B1

公开(公告)日：2013-03-06

申请号：EP06700474.7

申请日：2006-01-05

申请人： VisEn Medical, Inc.

发明人： LICHA, Kai ,  PESSEL, Martin ,  BAHNER, Malte ,  SCHIRNER, Michael

IPC分类号： A61K49/00

CPC分类号： A61K49/0032 ,  A61K49/0034 ,  A61K49/0058

公开(公告)号：EP1968431B1

公开(公告)日：2011-03-09

申请号：EP06849995.3

申请日：2006-12-21

申请人： Visen Medical, Inc.

发明人： YARED, Wael, I.

IPC分类号： A61B5/00 ,  A61B6/03 ,  G06T11/00 ,  G01N21/64

CPC分类号： A61B6/032 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/1077 ,  A61B6/4014 ,  A61B6/4417 ,  A61B6/482 ,  A61B6/485 ,  A61B6/508 ,  A61B6/5247 ,  A61B2503/40 ,  A61B2560/0223

摘要： The invention relates to a combined x-ray and optical (light-based) tomographic imaging system that provides functional information at greater resolution than can be achieved by optical tomography alone. The system is configured with one or more x-ray sources, x-ray detectors, light sources, and light detectors arranged on a gantry which rotates about an imaging chamber containing the object to be imaged. The system thereby allows both x-ray radiation and light to be directed into the object at multiple locations. Processing methods of the invention go beyond simple co-registration of images obtained from two or more imaging techniques. Both x-ray data and light data are used together in optical tomographic reconstruction to create the tomographic image, thereby allowing a more accurate and/or higher resolution final image.

公开(公告)号：EP2244741A2

公开(公告)日：2010-11-03

申请号：EP09702594.4

申请日：2009-01-17

申请人： Visen Medical, Inc.

发明人： RAJOPADHYE, Milind ,  GROVES, Kevin ,  PREDA, Dorin, V.

IPC分类号： A61K49/00 ,  A61K49/04

CPC分类号： A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

摘要翻译： 提供了用于体内和体外成像的分子内骤冷显像剂家族，其包含至少一个可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是未淬灭的，并且在用适当波长的光激发时能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。

公开(公告)号：EP1968431A2

公开(公告)日：2008-09-17

申请号：EP06849995.3

申请日：2006-12-21

申请人： Visen Medical, Inc.

发明人： YARED, Wael, I.

IPC分类号： A61B5/00 ,  A61B6/03 ,  G06T11/00 ,  G01N21/64

CPC分类号： A61B6/032 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/1077 ,  A61B6/4014 ,  A61B6/4417 ,  A61B6/482 ,  A61B6/485 ,  A61B6/508 ,  A61B6/5247 ,  A61B2503/40 ,  A61B2560/0223

摘要： The invention relates to a combined x-ray and optical (light-based) tomographic imaging system that provides functional information at greater resolution than can be achieved by optical tomography alone. The system is configured with one or more x-ray sources, x-ray detectors, light sources, and light detectors arranged on a gantry which rotates about an imaging chamber containing the object to be imaged. The system thereby allows both x-ray radiation and light to be directed into the object at multiple locations. Processing methods of the invention go beyond simple co-registration of images obtained from two or more imaging techniques. Both x-ray data and light data are used together in optical tomographic reconstruction to create the tomographic image, thereby allowing a more accurate and/or higher resolution final image.

公开(公告)号：EP1934211A1

公开(公告)日：2008-06-25

申请号：EP06802829.9

申请日：2006-09-01

申请人： Visen Medical, Inc.

发明人： NARAYANAN, Narasimhachari ,  GROVES, Kevin ,  PETERSON, Jeffrey, D. ,  RAJOPADHYE, Milind

IPC分类号： C07D419/02 ,  C09B23/02 ,  G01N33/533 ,  G01N33/58 ,  A61K49/00

CPC分类号： C09B23/086 ,  A61K49/0032 ,  A61K49/0052 ,  C07D209/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/083 ,  G01N33/533 ,  G01N33/537 ,  G01N33/582

摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应反应形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖的部分的相应缀合物及其用途。

公开(公告)号：EP0876428B1

公开(公告)日：2004-11-17

申请号：EP96934591.7

申请日：1996-10-08

申请人： Visen Medical, Inc.

发明人： DELLA CIANA, Leopoldo ,  GRIGNANI, Andrea ,  CASSULLO, Mariacristina ,  CAPUTO, Giuseppe

IPC分类号： C09B23/00 ,  G01N33/533 ,  C12Q1/68

CPC分类号： G01N33/533 ,  C09B23/0066 ,  C09B23/02 ,  Y10S436/80 ,  Y10S436/817

摘要： The present invention is directed to fluorescent dyes and its valence tautomers of formula (I), wherein Q represents a conjugated moiety that increases the fluorescent quantum yield of the compound; R1 is a functionalized group of the formula -(CH2)jY, wherein Y is selected from the group consisting of SO3H, COOH, NH2, CHO, NCS, epoxy, phthalimido, and COOZ, wherein Z represents a leaving group; R2 is a functionalized group of the formula -(CH2)kY', wherein Y' is selected from the group consisting of SO3H, COOH, NH2, CHO, NCS, epoxy, phthalimido, and COOZ, wherein Z represents a leaving group; M is a counterion selected from the group consisting of ammonium, alkali metal cations, and alkaline earth metal cations; n = 1 to 4; m = 1 to 4; j = 2 to 10; and k = 2 to 10.

公开(公告)号：EP1469989A2

公开(公告)日：2004-10-27

申请号：EP03705645.4

申请日：2003-01-02

申请人： Visen Medical, Inc.

发明人： GAW, Debra, A. ,  JOSEPHSON, Lee

IPC分类号： B32B5/16 ,  G01N33/15 ,  G01N33/543

CPC分类号： A61K49/1854 ,  A61K9/5026 ,  A61K9/5094 ,  B82Y5/00

摘要： Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.