摘要:
The present invention provides a new method for producing Engineered Heart Muscle (EHM) under chemically fully defined conditions and compounds all compatible with GMP regulations. The resulting human myocardium generates force and shows typical heart muscle properties.
摘要:
The present invention relates to a production method for fiber composite materials such as fiber insulation materials or fiber plates, chipboards, and oriented or unoriented structural boards and insulation materials and insulation plates made therefrom, wherein heating is performed first by means of hot air and then by means of hot steam. Said procedure leads to an unexpected heating of the fiber non-woven fabric or the chip mat and thus to a significantly improved method.
摘要:
The present invention relates to a vaccination which reduces the risk to contract melanoma to about half to third and moreover, within a five year period post diagnosis of malignant melanoma the risk to die is reduced to about half as compared to the non-vaccinated individuals. Beyond its effect on melanoma, the vaccination of the invention also may have protective effects against some other malignancies such as cancers of bladder, breast, esophagus, and kidney, against sarcomas and lymphomas, and against a multitude of micro-organisms which can induce severe and lethal infections or allergies. The present invention relates also to the use the yellow fever vaccine for the prophylactic vaccination against a malignancy, in particular melanoma, to the use of some other licensed vaccinations for the prophylactic vaccination against a malignancy, in particular melanoma, and to new synthetic vaccines which use the identified antigenic motifs.
摘要:
The present invention relates to the technical field of immunology and the treatment of diseases mediated and/or indicated by the presence of a ligand of NK receptor NKG2D, such as major histocompatibility complex class I chain related (MIC) A and B molecules on the cell surface of diseased tissue or cells. In particular, the present invention makes use of the surprising finding that the stress-inducible endogenous danger signals HSP70 and MICA/B synergistically activate NK cells against tumors. Methods and compositions for the prevention and treatment of infectious diseases, primary and in particular metastatic neoplastic diseases, including, but not limited to human sarcomas, carcinomas and melanomas are provided.
摘要:
Various examples of the disclosure pertain to using whole-slide images that depict healthy tissue for a training process for at least one machine-learning algorithm for digital pathology. For instance, an autoencoder neural network can be trained based on the healthy tissue.
摘要:
Die vorliegende Erfindung betrifft Nanocontainer für den synergistischen Transport von lipophilen und hydrophilen Wirkstoffen bzw. Nachweisreagenzien. Insbesondere bieten die erfindungsgemäßen Nanocontainer eine Möglichkeit zur Diagnostik und/oder Behandlung von Krankheiten mit Kombinationen von Wirkstoffen (Therapie) und Nachweisreagenzien (Diagnostik), welche verschiedene Löslichkeitseigenschaften aufweisen können. Des Weiteren betrifft die vorliegende Erfindung ein Verfahren zur Herstellung der erfindungsgemäßen Nanocontainer.
摘要:
The application describes a method for manufacturing a multilayer engineered heart muscle. Specifically, the method relates to (i) providing a liquid reconstitution mixture in a mould and (ii) culturing said mixture. The method is characterized by a sequential addition of one or more further liquid reconstitution mixtures in order to obtain a multilayer engineered heart muscle. Said muscle ideally has the form of a patch, a pouch, or a cylinder. Furthermore, the application relates to a multilayer engineered heart muscle comprising collagen, cardiac myocytes and non-myocytes originating from at least 2 layers. Said multilayer engineered heart muscle forms the basis for several in vitro and in vivo applications such as the production of a multilayer engineered heart muscle for use in a patient, for example for use in heart repair.