利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.015 秒)

    MASS PRODUCTION OF HUMAN PLURIPOTENT STEM CELL DERIVED CARDIAC STROMAL CELL
    1.
    发明公开
    MASS PRODUCTION OF HUMAN PLURIPOTENT STEM CELL DERIVED CARDIAC STROMAL CELL 审中-公开

    公开(公告)号：EP3945133A8

    公开(公告)日：2023-04-12

    申请号：EP20188364.2

    申请日：2020-07-29

    申请人： Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin

    发明人： Zimmermann, Wolfram-Hubertus ,  Tiburcy, Malte

    IPC分类号： C12N5/077 ,  C12N5/071

    摘要： The application describes a method for producing a population of cardiac stromal cells from pluripotent stem cells. Specifically, the method relates to (i) inducing epithelial-mesenchymal transition of pluripotent stem cell derived epicardial cells and (ii) amplifying the number of cardiac stromal cells in serum-free conditions. These cardiac stromal cells can be mass produced according to the described method and said cells maintain the expression of CD90, CD73 and CD44 in at least 80% of the cardiac stromal cells. Furthermore, the application relates to a population of cardiac stromal cells, which are pluripotent stem cells derived and wherein at least 80% of the cardiac stromal cells express CD90, CD73 and CD44. Said cardiac stromal form the basis for several in vitro and in vivo applications such as the production of engineered organ tissue and the support of, for example, heart repair. Also, a serum-free culture medium for the amplification of cardiac stromal cells is provided herein.

    POTENCY ASSAY FOR PHARMACEUTICAL PRODUCTS
    2.
    发明公开
    POTENCY ASSAY FOR PHARMACEUTICAL PRODUCTS 审中-公开

    公开(公告)号：EP4386384A1

    公开(公告)日：2024-06-19

    申请号：EP22213839.8

    申请日：2022-12-15

    申请人： Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin ,  Repairon Muscle UG (haftungsbeschränkt)

    发明人： Zimmermann, Wolfram ,  Germeroth, Lothar ,  Tiburcy, Malte ,  Zafeiriou, Maria-Patapia ,  Lutz, Susanne

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5008 ,  G01N33/5058 ,  G01N33/5061

    摘要： The present invention describes a method for assessing the potency of a pharmaceutical product assumed to be effective in treating a disorder, preferably a genetic disorder or a non-genetic disorder, wherein the disorder results in an impaired functionality of a physiological bodily function of a subject having the disorder, wherein the method comprises: (i) incubating an engineered tissue with the pharmaceutical product, wherein the engineered tissue is or has been modified to be representative for the disorder; (ii) determining at least one physical parameter of the engineered tissue resulting from step (i), wherein the physical parameter is a measure of the functionality of the physiological bodily function, and (iii) determining whether a value of the at least one physical parameter determined in step (ii) meets a predetermined threshold of said physical parameter, which determines whether the pharmaceutical product has potency, wherein, if said value of the at least one physical parameter exceeds the predetermined threshold, potency of the pharmaceutical product is indicated for treating the disorder by at least partially restoring the functionality of the physiological bodily function.