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51.发明公开METHOD OF PRODUCING A THYMIC MICROENVIRONMENT THAT SUPPORTS THE DEVELOPMENT OF DENDRITIC CELLS 失效用于生产树突状细胞发展的胸腺微环境UNZERSTUETZUNG
公开(公告)号：EP0931138A1
公开(公告)日：1999-07-28
申请号：EP97910881.0
申请日：1997-10-10
申请人： DUKE UNIVERSITY
CPC分类号： C12N5/0639 , A61K38/00 , A61K2039/5154 , C12N5/065 , C12N2500/40 , C12N2501/01 , C12N2501/11 , C12N2501/25 , C12N2501/33 , C12N2501/39 , C12N2502/1185 , C12N2502/13
摘要： The present invention relates, in general, to thymic microenvironment and, in particular, to a method of producing a thymic microenvironment. The invention further relates to a method of treating congenital and acquired immunodeficiencies using a thymic microenvironment produced in vitro. Included in acquired immunodeficiencies are syndromes seen in malignant and autoimmune diseases as well as traditional T cell immunodeficiency diseases such as occurs in AIDS.
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公开(公告)号：EP0856009A1
公开(公告)日：1998-08-05
申请号：EP97936095.0
申请日：1997-07-17
发明人： HAYNES, Barton, F. , ARUFFO, Alejandro , PATEL, Dhavalkumar , BOWEN, Michael, A. , MARQUARDT, Hans , SIADAK, Anthony, W.
IPC分类号： G01N33 , A61K31 , A61K39 , A61K45 , A61P37 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , A61K38 , C12R1
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K16/2803 , C07K16/2896 , C07K2319/00 , C07K2319/30 , G01N33/68 , G01N2333/70503
摘要： The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction. The invention also relates to antibodies, and binding fragments thereof, specific for CD6 ligand.
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公开(公告)号：EP0618804A1
公开(公告)日：1994-10-12
申请号：EP92922125.0
申请日：1992-10-08
申请人： DUKE UNIVERSITY
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/14022
摘要： L'invention concerne des préparations immunogènes de peptides comprenant des séquences d'acides aminés correspondant à des déterminants antigéniques de la glycoprotéine d'enveloppe de HTLV-I ou HTLV-II couplés de manière covalente, directement ou par l'intermédiaire d'une molécule d'espacement, à des molécules porteuses permettant la vaccination de mammifères. L'invention concerne également l'utilisation desdits peptides dans des méthodes de diagnostic.
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公开(公告)号：EP4229070A1
公开(公告)日：2023-08-23
申请号：EP21883746.6
申请日：2021-10-19
IPC分类号： C07K14/005 , C07K14/155 , A61K39/12 , C07K14/08
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公开(公告)号：EP3271022A2
公开(公告)日：2018-01-24
申请号：EP16765900.2
申请日：2016-03-21
发明人： HAYNES, Barton, F. , LIAO, Hua-xin , MOODY, M., Anthony , WILLIAMS, Latonya , WIEHE, Kevin, J. , OFEK, Gilad, Adi
IPC分类号： A61P31/18 , A61K39/42 , A61K39/395 , C12N15/13 , C07K14/16
CPC分类号： A61K39/42 , C07K16/1045 , C07K16/1063 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention is directed to HIV- 1 neutralizing antibodies and methods for their uses.
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公开(公告)号：EP2986644A1
公开(公告)日：2016-02-24
申请号：EP14785790.8
申请日：2014-04-15
申请人： Duke University , Sloan-kettering Institute For Cancer Research , Dana-Farber Cancer Institute, Inc.
发明人： HAYNES, Barton, F. , LIAO, Hua-xin , DANISHEFSKY, Samuel , PARK, Peter , SODROSKI, Joseph , AUSSEDAT, Baptiste , VOHRA, Yusuf
CPC分类号： A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K14/001 , C07K14/005 , C07K14/162 , C12N2740/16034 , C12N2740/16134 , G01N33/56988 , G01N2333/16
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and using same.
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公开(公告)号：EP2788026A2
公开(公告)日：2014-10-15
申请号：EP12854613.2
申请日：2012-12-05
申请人： Duke University , The Government of The United States, as represented by The Secretary of The Army, on behalf of Walter Reed Army , New York University
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C07K14/162 , C07K16/1063 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C12N2710/24043 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
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公开(公告)号：EP2542566A2
公开(公告)日：2013-01-09
申请号：EP11751024.8
申请日：2011-03-03
CPC分类号： A61K39/21 , A61K39/12 , C12N7/00 , C12N2740/16021 , C12N2740/16034
摘要： The present invention relates, in general, to HIV-1 and, in particular, to a molecular clone of HIV- 1. The invention further relates to methods of inducing an immune response to HIV-1 in a patient and to immunogens suitable for use in such methods. The invention also relates to anti-HIV-1 antibodies and to methods of using same to prevent or treat HIV-infection.
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