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公开(公告)号：EP0856009A1
公开(公告)日：1998-08-05
申请号：EP97936095.0
申请日：1997-07-17
发明人： HAYNES, Barton, F. , ARUFFO, Alejandro , PATEL, Dhavalkumar , BOWEN, Michael, A. , MARQUARDT, Hans , SIADAK, Anthony, W.
IPC分类号： G01N33 , A61K31 , A61K39 , A61K45 , A61P37 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , A61K38 , C12R1
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K16/2803 , C07K16/2896 , C07K2319/00 , C07K2319/30 , G01N33/68 , G01N2333/70503
摘要： The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction. The invention also relates to antibodies, and binding fragments thereof, specific for CD6 ligand.
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公开(公告)号：EP0830373A1
公开(公告)日：1998-03-25
申请号：EP96913873.0
申请日：1996-04-29
发明人： HAYNES, Barton, F. , ARUFFO, Alejandro , PATEL, Dhavalkumar , BOWEN, Michael, A. , MARQUARDT, Hans
CPC分类号： C07K14/70503 , A61K38/00 , C07K16/2803 , C07K2319/30
摘要： The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction.
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公开(公告)号：EP4415752A2
公开(公告)日：2024-08-21
申请号：EP22881744.1
申请日：2022-10-12
申请人： Duke University , The Trustees of the University of Pennsylvania , Korber, Bette, T. , Wagh, Kshitij, G. , Shaw, George, M. , Weissman, Drew , Alameh, Mohamad-Gabriel
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公开(公告)号：EP4284427A1
公开(公告)日：2023-12-06
申请号：EP22746696.8
申请日：2022-01-28
申请人： Duke University
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , A61P31/18 , A61K39/39
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公开(公告)号：EP2739300B1
公开(公告)日：2019-06-19
申请号：EP12807743.5
申请日：2012-07-05
申请人： Duke University , Children's Medical Center Corporation , The Government of The US, as Represented by The Secretary of the Army, on behalf of Walter Reed Army Institute of Research
IPC分类号： A61K38/17 , A61K38/16 , A61K39/245 , A61K48/00 , A61P37/00 , A61P31/00 , A61K39/21 , C07K14/005
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公开(公告)号：EP3160986A2
公开(公告)日：2017-05-03
申请号：EP15812422.2
申请日：2015-06-25
申请人： Duke University
CPC分类号： A61K39/21 , A61K39/12 , C07K14/005 , C12N2740/16071 , C12N2740/16122 , C12N2740/16134
摘要： In certain aspects the invention provides HIV-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with recombinant expression in a cell line, and N-terminal deletion which improves envelope expression as a monomer.
摘要翻译： 在某些方面，本发明提供了HIV-1工程包膜蛋白及其用途。 工程包膜包含防止与细胞系中的重组表达相关的包膜的切割的序列和改善作为单体的包膜表达的N端缺失。
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7.发明公开COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF 审中-公开ZUSAMMENSETZUNGEN MIT CH848-HÜLLPROTEINENUND VERWENDUNGEN DAVON
公开(公告)号：EP3126502A1
公开(公告)日：2017-02-08
申请号：EP15772335.4
申请日：2015-03-31
申请人： Duke University , The Trustees of The University of Pennsylvania , Los Alamos National Security, LLC
发明人： HAYNES, Barton, F. , HAHN, Beatrice, H. , SHAW, George, M. , KORBER, Bette, T. , HRABER, Peter, T.
IPC分类号： C12N15/49 , C07K14/155 , A61K31/7088 , A61K39/21
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/21 , A61K2039/70 , C07K14/155 , C12N2740/16034
摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
摘要翻译： 在某些方面，本发明提供包含CH848 HIV-1包膜的致突变组合物及其在受试者例如人受试者中诱导免疫应答的方法中的用途。
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8.发明公开METHOD FOR THE GENERATION OF MONOCLONAL ANTIBODIES DERIVED FROM HUMAN B CELLS 审中-公开用于人B细胞PRODUCING获得单克隆抗体
公开(公告)号：EP2556148A2
公开(公告)日：2013-02-13
申请号：EP11766283.3
申请日：2011-04-11
申请人： Duke University
发明人： HAYNES, Barton, F. , BONSIGNORI, Mattia , HWANG, Kwan-Ki , LIAO, Hua-Xin , MONTEFIORI, David, C. , LUFTIG, Micah, A.
IPC分类号： C12N5/0781 , C12N5/10 , C07K16/18
CPC分类号： C07K16/00 , C07K16/1045 , C07K2317/76
摘要： The present invention relates, in general, to human B cells, and, in particular to a method of immortalizing and cloning human B cells and to monoclonal antibodies derived therefrom. The invention further relates to methods of using the monoclonal antibodies for therapeutic and diagnostic purposes.
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公开(公告)号：EP1917040A2
公开(公告)日：2008-05-07
申请号：EP06802155.9
申请日：2006-08-23
申请人： The Regents of the University of California , Beth Israel Deaconess Medical Center , Duke University , University of Alabama at Birmingham Research Foundation
发明人： KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
IPC分类号： A61K48/00
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
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10.发明公开COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS (EIGHT VALENT HIV-1 COMPOSITION AND METHODS) 审中-公开包含CH505包膜的组合物和修剪物（八价HIV-1组合物和方法）
公开(公告)号：EP3240559A1
公开(公告)日：2017-11-08
申请号：EP15873776.7
申请日：2015-12-23
CPC分类号： C07K14/005 , A61K35/76 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , C12N2740/16122 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV- 1 envelopes suitable for use as immunogens, and methods of using these immunogens in vaccination to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens and methods of using these comprise an immune modulating component.
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