公开(公告)号：EP2912055A1

公开(公告)日：2015-09-02

申请号：EP13848800.2

申请日：2013-10-28

申请人： Duke University ,  Sloan Kettering Institute For Cancer Research ,  Dana-Farber Cancer Institute, Inc.

发明人： HAYNES, Barton, F. ,  LIAO, Hua-xin ,  ALAM, S., Munir ,  DANISHEFSKY, Samuel ,  AUSSEDAT, Baptiste ,  PARK, Peter, K. ,  VOHRA, Yusuf ,  SODROSKI, Joseph

IPC分类号： C07K14/155 ,  C07K16/10

CPC分类号： A61K39/21 ,  A61K39/12 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus- ! (HIV- 1), and, in particular to a vaccine for HiV-l and to methods of making and using same. The present invention provides synthetic glycosylated HIV-1 peptides, method for their preparation and use.

公开(公告)号：EP2986644A1

公开(公告)日：2016-02-24

申请号：EP14785790.8

申请日：2014-04-15

申请人： Duke University ,  Sloan-kettering Institute For Cancer Research ,  Dana-Farber Cancer Institute, Inc.

发明人： HAYNES, Barton, F. ,  LIAO, Hua-xin ,  DANISHEFSKY, Samuel ,  PARK, Peter ,  SODROSKI, Joseph ,  AUSSEDAT, Baptiste ,  VOHRA, Yusuf

IPC分类号： C07K19/00 ,  C07K14/00 ,  G01N33/53 ,  A61P31/18

CPC分类号： A61K39/12 ,  A61K2039/545 ,  A61K2039/55566 ,  C07K14/001 ,  C07K14/005 ,  C07K14/162 ,  C12N2740/16034 ,  C12N2740/16134 ,  G01N33/56988 ,  G01N2333/16

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and using same.

公开(公告)号：EP1753777A2

公开(公告)日：2007-02-21

申请号：EP05723412.2

申请日：2005-02-17

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： SODROSKI, Joseph ,  STREMLAU, Matthew ,  OWENS, Christopher, M.

IPC分类号： C07K14/435

CPC分类号： C07K14/705 ,  C12Q1/701 ,  C12Q1/703

摘要： The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g., HIV infection using the modulators of the invention.

公开(公告)号：EP1753777B1

公开(公告)日：2014-05-07

申请号：EP05723412.2

申请日：2005-02-17

申请人： Dana-Farber Cancer Institute, Inc.

发明人： SODROSKI, Joseph ,  STREMLAU, Matthew ,  OWENS, Christopher, M.

IPC分类号： C07H21/02 ,  C07K14/705 ,  C12Q1/70

CPC分类号： C07K14/705 ,  C12Q1/701 ,  C12Q1/703

公开(公告)号：EP1940867A2

公开(公告)日：2008-07-09

申请号：EP06814287.6

申请日：2006-09-06

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services ,  Dana Farber Cancer Institute, Inc. ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： KWONG, Peter, D. ,  ZHOH, Tongqing ,  XU, Ling ,  NABEL, Gary ,  DEY, Barna ,  WYATT, Richard ,  XIANG, Shi-Hua ,  SODROSKI, Joseph ,  BURTON, Dennis ,  ARTHOS, James

IPC分类号： C07K14/16 ,  C12N15/49 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C07K14/70514 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present disclosure relates to stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4-binding site antibody bl2, to crystalline forms of the stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4- binding site antibody b 12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.

公开(公告)号：EP2136835A1

公开(公告)日：2009-12-30

申请号：EP08742681.3

申请日：2008-04-10

申请人： Duke University ,  Dana-Farber Cancer Institute

发明人： HAYNES, Barton, F. ,  LIAO, Hua-xin ,  MA, Ben-jiang ,  SODROSKI, Joseph

IPC分类号： A61K39/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  C12N2740/16034

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to HIV-I envelope (Env) immunogens.