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公开(公告)号：EP2258387A2
公开(公告)日：2010-12-08
申请号：EP10177892.6
申请日：2003-07-31
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译： 本发明涉及用于治疗和预防奈瑟氏球菌病的免疫原性组合物和疫苗。 本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原的组合，包括粘附素，自体转运蛋白，毒素，铁获得蛋白和膜相关蛋白（优选整体外膜蛋白）。 抗原的这种组合能够针对奈桑氏生命周期的不同方面靶向免疫应答，导致更有效的免疫应答。
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公开(公告)号：EP2140878A1
公开(公告)日：2010-01-06
申请号：EP09173889.8
申请日：2001-09-12
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a combination of 2 or more S pneumoniae proteins, their manufacture and use in medicine as a vaccine. Such combinations are particularly useful for the protection of infants and elderly against streptococcal infection.
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公开(公告)号：EP1787655A3
公开(公告)日：2008-02-13
申请号：EP06124085.9
申请日：2000-07-31
发明人： Berthet, Francois-Xavier J. , Dalemans, Wilfried L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention have one or more genetic changes in the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
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公开(公告)号：EP1774977A2
公开(公告)日：2007-04-18
申请号：EP06124088.3
申请日：2000-07-31
发明人： Berthet, Francois-Xavier Jacques , Dalemans, Wilfred L. J. , Denoel, Philippe , Dequesne, Guy , Feron, Christiane , Lobet, Yves , Poolman, Jan , Thiry, Georges , Thonnard, Joelle , Voet, Pierre
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immune-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制造泡状体的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 本发明的泡沫的特征在于对细菌染色体的一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒。
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