公开(公告)号：EP1757692A4

公开(公告)日：2007-10-31

申请号：EP05734386

申请日：2005-04-20

申请人： DAIICHI SEIYAKU CO ,  KAZUSA DNA RES INST FOUNDATION

发明人： OHARA OSAMU ,  NAGASE TAKAHIRO ,  OHISHI MICHIO ,  YOKOTA HIROSHI ,  KAMIDA OSAMU

IPC分类号： C12N15/12 ,  A61K38/00 ,  A61K45/00 ,  A61P11/00 ,  A61P35/00 ,  C07K14/82 ,  C07K16/32 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/44 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566

CPC分类号： C07K14/82 ,  A61K38/00 ,  C12Q1/44 ,  G01N2500/00 ,  Y10T436/143333

摘要： It is intended to provide a gene encoding a novel protein which binds to an Rho family protein constituting one group of low-molecular weight GTP-binding proteins and can exert the guanine nucleotide exchange factor (GEF) activity, namely, a polynucleotide represented by a base sequence described in SEQ ID NO:1 or 3, a complementary chain thereof, a homolog of the above polynucleotide, a protein encoded by the above polynucleotide, a vector containing the above polynucleotide, a transformant containing the above vector, an antibody against the protein encoded by the above polynucleotide, a method of identifying a compound inhibiting the function and/or expression of the protein encoded by the above polynucleotide, a method of judging a disease, a medicinal composition and a reagent kit.

公开(公告)号：EP1591443A4

公开(公告)日：2007-09-12

申请号：EP04708886

申请日：2004-02-06

申请人： DAIICHI SEIYAKU CO

发明人： KANAYA NAOAKI ,  ISHIHARA HIROAKI ,  KIMURA YOUICHI ,  ISHIYAMA TAKASHI ,  OCHIAI YUICHI

IPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D231/14 ,  C07D401/14 ,  C07D403/04 ,  C07D413/14 ,  C07D417/14 ,  C07D491/052 ,  C07D493/04

CPC分类号： A61K31/551 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/541 ,  C07D231/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/14 ,  C07D493/04

摘要： A potent antiplatelet aggregation agent which inhibits neither COX-1 nor COX-2. It is a compound represented by the following general formula (I): (I) or general formula (II): (II) a salt of the compound, or a solvate of either. Also provided are: a medicine containing the compound, salt, or solvate; and a preventive and/or therapeutic agent for ischemic diseases which contains the compound, salt, or solvate

公开(公告)号：EP1634879A4

公开(公告)日：2007-09-05

申请号：EP04746109

申请日：2004-06-18

申请人： DAIICHI SEIYAKU CO

发明人： MUTO MAKOTO ,  KITAGAWA YUTAKA

IPC分类号： C07D401/04

CPC分类号： C07D401/04

摘要： A technique for position-selectively introducing an amino group into a difluorobenzoic acid compound; a novel process for producing a quinolonecarboxylic acid derivative serving as an antibacterial; and an intermediate (6) for the derivative. The process, which is for producing a compound represented by the formula (1), is characterized by treating a compound represented by the following formula (6): with a base in a water-containing solution.

公开(公告)号：EP1757690A4

公开(公告)日：2007-07-18

申请号：EP05730477

申请日：2005-04-14

申请人： DAIICHI SEIYAKU CO ,  KAZUSA DNA RES INST

发明人： OHARA OSAMU ,  NAGASE TAKAHIRO ,  OHISHI MICHIO ,  YOKOTA HIROSHI ,  KAMIDA OSAMU

IPC分类号： C12N15/12 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/18 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/44 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

CPC分类号： G01N33/57446 ,  A61K38/00 ,  C07K14/82 ,  C12Q1/44 ,  G01N33/57407 ,  G01N2500/00 ,  Y10T436/143333

摘要： It is intended to provide a gene encoding a novel protein having a guanine nucleotide exchange factor (GEF) activity to proteins belonging to the Rho family (i.e., a group of low-molecular weight GTP-binding proteins), namely, a polynucleotide comprising a base sequence represented by SEQ ID NO:1, 3 or 5 or its complementary chain; a homolog of the above polynucleotide; a protein encoded by the above polynucleotide; a vector containing the above polynucleotide; a transformant containing the above vector; an antibody against a protein encoded by the above polynucleotide; a method of identifying a compound inhibiting the function and/or expression of the protein encoded by the above polynucleotide; a method of judging a disease; a medicinal composition; and a reagent kit.

摘要翻译： 编码具有Rho家族蛋白的鸟嘌呤核苷酸交换因子（GEF）活性的新蛋白质的基因是一组小GTP结合蛋白，即由SEQ ID NO：1，SEQ ID NO：1所示的核苷酸序列所示的多核苷酸 SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有该多核苷酸的载体，含有载体的转染子，由该多核苷酸编码的蛋白质的抗体 提供了鉴定抑制多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，疾病的测定方法，药物组合物和试剂盒。

公开(公告)号：EP1518856A4

公开(公告)日：2006-12-13

申请号：EP03728079

申请日：2003-05-16

申请人： DAIICHI SEIYAKU CO

发明人： OHTA N ,  AKIBA T

IPC分类号： C07D209/54 ,  C07D401/04

CPC分类号： C07D209/54 ,  C07D401/04

摘要： A production process shown by the following reaction scheme. (4) (3) → (5) → (7) (6) → (8) → (2) By the process, a compound (2), which is useful as an antibacterial, can be produced at low cost in high yield.

公开(公告)号：EP1020193A4

公开(公告)日：2006-05-24

申请号：EP98944298

申请日：1998-09-29

申请人： DAIICHI SEIYAKU CO

发明人： II NORITAKA ,  MURAKAMI TOSHIO

IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K31/00 ,  A61K45/08 ,  A61K47/26 ,  A61P1/04

CPC分类号： A61K9/1623 ,  A61K9/0056 ,  A61K9/1611 ,  A61K9/2009 ,  A61K9/2018

摘要： An oral preparation having an excellent palatability obtained by modifying an unpleasant taste of a medicine by adding a sugar-alcohol having a heat of dissolution of -20 cal/g or below and a pH regulator to the medicine having an unpleasant taste.

公开(公告)号：EP1258478A4

公开(公告)日：2006-03-15

申请号：EP01906267

申请日：2001-02-23

申请人： DAIICHI SEIYAKU CO

发明人： SAITO TATSURU ,  JOUNO TOSHIAKI ,  TANI YU-ICHIRO ,  AKIBA TOSHIFUMI

IPC分类号： A01N43/42 ,  A61K31/47 ,  A61K31/4709 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04

CPC分类号： C07D215/56 ,  A01N43/42 ,  A61K31/47 ,  A61K31/4709 ,  C07D401/04

摘要： A process for efficiently producing artificial quinolonecarboxylic acid-type antimicrobials which are expected as excellent drugs and pesticides and intermediates compounds to be used therein. According to this process, an amine substituent, which is a substituent at the 7-position of quinolonecarboxylic acid derivatives, can be efficiently introduced.

公开(公告)号：EP1466975A4

公开(公告)日：2005-10-12

申请号：EP02788621

申请日：2002-11-20

申请人： DAIICHI SEIYAKU CO ,  KAZUSA DNA RES INST FOUNDATION

发明人： OHARA OSAMU ,  NAGASE TAKAHIRO ,  OHISHI MICHIO ,  YOKOTA HIROSHI ,  ARAI YASUKO

IPC分类号： A61K38/17 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  G01N33/68 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  C07K14/435 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/19

CPC分类号： C07K14/47 ,  A61K38/1709 ,  G01N33/6896

摘要： A protein A binding to the N-methyl-D-aspartic acid NMDA receptor and another protein B interacting with the protein A are provided. Based on the fact that these proteins remarkably promote the signal transfer of the NMDA receptor, controllers inhibitors or promoters for the expression and/or functions of these proteins and a method of controlling the same are provided. Thus, it becomes possible to clarify diseases caused by failures in the NMDA receptor signal transfer or memory regeneration, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and polyglutamine disease as well as to prevent, ameliorate or treat these diseases.

公开(公告)号：EP1445327A4

公开(公告)日：2005-09-14

申请号：EP02775378

申请日：2002-10-22

申请人： DAIICHI SEIYAKU CO

发明人： KITAMURA AKIHIRO ,  NAKAJIMA RYOHEI

IPC分类号： A61P31/10 ,  C12Q1/02 ,  C12Q1/18 ,  G01N33/50 ,  A61K45/00 ,  G01N33/15

CPC分类号： G01N33/5014 ,  C12Q1/025 ,  C12Q1/18 ,  G01N33/5008 ,  G01N2400/00 ,  G01N2500/00

摘要： A method of screening a drug acting on cell wall which involves: 1 the step of culturing a microorganism immobilized on cell wall with the use of a reporter protein as a GPI anchor protein in the presence of a test drug acting on cell wall 2 the step of analyzing a sugar chain originating in the reporter protein released into the liquid culture medium of the microorganism and 3 the step of presuming the action point of the drug on the cell wall based on the data of the sugar chain originating in the reporter protein obtained in the above step 2. By easily and adequately judging the action points of drugs having an inhibitory effect on cell wall, a cell wall-acting drug acting on a specific action point can be efficiently screened.

公开(公告)号：EP1489178A4

公开(公告)日：2005-08-24

申请号：EP03710429

申请日：2003-03-19

申请人： DAIICHI SEIYAKU CO

发明人： YOKOTA HIROSHI ,  SATOH KAZUKI

IPC分类号： A61P25/00 ,  C07K14/47 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  G01N33/566 ,  A61K35/76 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  C07K16/18 ,  C12N5/10 ,  C12N15/63 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

CPC分类号： C07K14/47 ,  G01N33/566

摘要： A polypeptide binding to syntaxin 1a and comprising the amino acid sequence represented by SEQ ID NO:1 in Sequence Listing or a polypeptide binding to syntaxin 1a and having a homology of at least about 90% with the above amino acid sequence; peptide fragments of these polypeptides; and polynucleotides encoding the same or complementary strands thereof. Inhibitors, antagonists and potentiators for the physiological effects of these polypeptides; and medicinal compositions using the same. Using genetic engineering techniques, a process for producing the above polypeptides or peptides; a method of identifying the above inhibitors, antagonists and potentiators; and a method and a kit for diagnosing a disease in which the polypeptides participate.