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    AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS
    52.
    发明公开
    AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS 失效
    AMINOVERBINDUNGEN UND ANGIOTENSIN IV REZEPTOR AGONISTEN

    公开(公告)号：EP0882699A1

    公开(公告)日：1998-12-09

    申请号：EP97933908.2

    申请日：1997-08-05

    申请人： TAISHO PHARMACEUTICAL CO. LTD ,  SAGAMI CHEMICAL RESEARCH CENTER

    发明人： KOBORI, Takeo ,  GODA, Kenichi ,  SUGIMOTO, Kikuo ,  OTA, Tomomi, Taisho Pharmaceutical Co., Ltd. ,  TOMISAWA, Kazuyuki, Taisho Pharmaceutical Co. Ltd.

    IPC分类号： C07C211/13 ,  C07C211/18 ,  C07C211/22 ,  C07C211/25 ,  C07C211/27 ,  C07C211/28 ,  C07C215/52 ,  C07K5/06 ,  C07K5/08 ,  A61K31/165 ,  A61K31/24

    CPC分类号： C07D213/40 ,  C07C237/20 ,  C07D215/12

    摘要： The present invention provides an amino compound represented by Formula:
    wherein X is CH 2 NH or CONH, Y is CH 2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R 4 )R 5 , CH 2 CH(R 4 )R 5 or an alkoxycarbonyl group, R 1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R 2 and R 3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R 4 and R 5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.

    摘要翻译： 本发明提供由式：表示的氨基化合物，其中X为CH 2 NH或CONH，Y为CH 2 NH或CONH，条件是X和Y不同时为CONH; Z是CH = C（R 4）R 5，CH 2 CH（R 4）R 5或烷氧基羰基，R 1是氢原子; 低级烷基，环烷基，环烷基取代的烷基，芳烷基或芳基，其各自为取代或未取代的，R 2和R 3各自独立地为低级烷基或 每个基团为取代或未取代的芳烷基，R 4和R 5各自独立地为氢原子; 其各自为取代或未取代的烷基，芳烷基，芳基或杂芳基，或其药学上可接受的盐; 包含式（1）的氨基化合物或其药学上可接受的盐的药物; 和含有与有效成分相同的血管紧张素IV受体激动剂，其特别可用作血管紧张素IV参与的各种疾病的治疗药物（拮抗剂或激动剂），例如加速肾血流量，脑血管舒张 ，抑制细胞增殖和高血症。

    PYRIDINE DERIVATIVES
    54.
    发明公开
    PYRIDINE DERIVATIVES 失效
    PYRIDINDERIVATE

    公开(公告)号：EP0795545A1

    公开(公告)日：1997-09-17

    申请号：EP95937181.6

    申请日：1995-11-27

    申请人： TAISHO PHARMACEUTICAL CO. LTD

    发明人： SHIRAI, Hirofusa ,  HANABUSA, Kenji ,  TAKAHASHI, Yuki Taisho Pharmaceutical Co., Ltd. ,  MIZOBE, Fumio Taisho Pharmaceutical Co., Ltd. ,  HANADA, Kazunori Taisho Pharmaceutical Co., Ltd.

    IPC分类号： C07D213/55 ,  C07D213/56 ,  C07D213/40 ,  A61K31/44

    CPC分类号： C07D213/40 ,  C07D213/38 ,  C07D213/55 ,  C07D213/56

    摘要： A pyridine derivative represented by the following formula:
    , where R 1 is a methyl group or a functional group represented by any one of the following formulae:

            ―CONHCH 2 CH 2 N(CH 3 ) 2



            ―CONHCH 2 CH 2 CH 2 N(CH 3 ) 2



            ―COOCH 2 CH 2 N(CH 3 ) 2



            ―COOCH 2 CH 2 N(CH 2 CH 3 ) 2



            ―NHCOCH 2 N(CH 3 ) 2



            ―NHCOCH 2 N(CH 2 CH 3 ) 2

    and R 2 is a hydrogen atom, an amino group or a functional group represented by any one of the following formulae:

            ―CONHCH 2 CH 2 N(CH 3 ) 2




            ―COOCH 2 CH 2 N(CH 3 ) 2



            ―NHCOCH 2 N(CH 3 ) 2



            ―NHCOCH 2 N(CH 2 CH 3 ) 2

    or a salt thereof directly or indirectly acts on neuronal cells in vivo and is expected to show an effect on amelioration and curing of nerve disorders due to neuronal degeneration, with application as a drug for ameliorating and curing, for example, traumatic symptoms and maladies, those induced by drugs such as alcohol, antineoplastic agents, etc., inflammatory ones, metabolic ones as observed in diabetes, etc., and furthermore those due to idiopathic degeneration of peripheral nerves, and also with application as drugs for ameliorating and curing symptoms and maladies due to degeneration of central nerves, for example, Alzheimer's disease and cerebrovascular ischemia, Down syndrome, Parkinson's disease, Huntington chorea, diseases secondary to cerebral ischemia, cerebral infarction, intracerebral bleeding, head injuries, etc., amnesia, spinal neuropathy, etc.

    摘要翻译： 由下式表示的吡啶衍生物：，其中R 1是由下式中的任一个表示的甲基或官能团：-CONHCH 2 CH 2 N（CH 3）2 -CONHCH 2 CH 2 CH 2 N（CH 3）2 -COOCH 2 CH 2 N（CH 3） CH 3）2 -COOCH 2 CH 2 N（CH 2 CH 3）2 -NHCOCH 2 N（CH 3）2 -NHCOCH 2 N（CH 2 CH 3）2和R 2是由下式表示的氢原子，氨基或官能团：-CONHCH2CH2N（ CH3）2 -COOCH2CH2N（CH3）2 -NHCOCH2N（CH3）2 -NHCOCH2N（CH2CH3）2或其盐在体内直接或间接作用于神经元细胞，预计会显示出对神经的改善和治愈的作用 由于神经元变性引起的疾病，作为改善和治愈的药物，例如外伤性症状和疾病，由诸如酒精，抗肿瘤药物等药物引起的疾病，炎性炎症，糖尿病中观察到的代谢性疾病等。 ，而且由于周围神经的特发性退化，以及应用a 用于改善和治疗由于中枢神经变性引起的症状和疾病的药物，例如阿尔茨海默病和脑血管缺血，唐氏综合症，帕金森氏症，亨廷顿舞蹈病，脑缺血继发性疾病，脑梗死，脑内出血，头部损伤等 遗忘症，脊髓神经病变等

    PHARMACEUTICAL USE OF TERPYRIDINE DERIVATIVE
    59.
    发明公开
    PHARMACEUTICAL USE OF TERPYRIDINE DERIVATIVE 失效
    十二烷基吡啶衍生物的药物用途

    公开(公告)号：EP0677293A1

    公开(公告)日：1995-10-18

    申请号：EP94903094.4

    申请日：1993-12-28

    申请人： TAISHO PHARMACEUTICAL CO. LTD

    发明人： SHIRAI, Hirofusa ,  HANABUSA, Kenji ,  TAKAHASHI, Yuki, Taisho Pharmaceutical Co., Ltd. ,  MIZOBE, Fumio, Taisho Pharmaceutical Co., Ltd. ,  HANADA, Kazunori, Taisho Pharmaceutical Co., Ltd.

    IPC分类号： A61K31/44 ,  C07D213/22

    CPC分类号： C07D213/22 ,  C07D213/26 ,  C07D213/30 ,  C07D213/38 ,  C07D213/55 ,  C07D401/14

    摘要： A terpyridine derivative represented by general formula (I) (wherein R represents hydrogen, (un)substituted phenyl, pyridyl, etc.), which has the effect of promoting the production of nerve growth factors or a neurotrophic factor activity. Hence it can be used as an ameliorant or remedy for the symptoms and diseases accompanying peripheral nerve degeneration which is idiopathic or caused by trauma, chemicals such as alcohol or anticancer drug, inflammation, or metabolism as observed in, for example, diabetes. In addition, it can be used as an ameliorant or remedy for the symptoms and diseases accompanying central nerve degeneration, such as senile dementia of Alzheimer type, cerebrovascular dementia, Down's syndrome, Parkinson's disease or Hantington's chorea, mental and motor function incompetences caused by cerebral ischemia, cerebral infarction, cerebral hemorrhage or head injury, spinal neuroparalysis, and so forth.

    摘要翻译： 由通式（I）表示的三联吡啶衍生物（其中R表示氢，（未）取代的苯基，吡啶基等）具有促进神经生长因子或神经营养因子活性的作用。 因此，它可以用作伴随周围神经变性的特发性或由外伤引起的症状和疾病，化学物质如酒精或抗癌药物，炎症或代谢如在例如糖尿病中观察到的改善或治疗。 此外，它还可用作阿尔茨海默型老年痴呆，脑血管性痴呆，唐氏综合症，帕金森病或亨廷顿舞蹈病等伴随中枢神经退行性症状和疾病的改善药物或治疗药物，以及由大脑引起的智力和运动功能不全 局部缺血，脑梗塞，脑出血或头部损伤，脊髓神经麻痹等。