公开(公告)号：EP2451972B1

公开(公告)日：2016-05-04

申请号：EP10734406.1

申请日：2010-07-09

申请人： Abbott Molecular Inc.

发明人： COON, John ,  MORRISON, Larry

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  A61K31/5377 ,  C12Q2543/10 ,  C12Q2600/106 ,  C12Q2600/112

公开(公告)号：EP2971091A1

公开(公告)日：2016-01-20

申请号：EP14717312.4

申请日：2014-03-13

申请人： Abbott Molecular Inc.

发明人： SOKOLOVA, Irina ,  SONG, Minghao ,  SITAILO, Svetlana ,  POLICHT, Frank

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6841 ,  C12Q2537/16 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N1/30 ,  G01N33/5091 ,  G01N33/57419 ,  G01N2001/305 ,  C12Q2527/125 ,  C12Q2543/10

摘要： A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support.

公开(公告)号：EP2971087A1

公开(公告)日：2016-01-20

申请号：EP14714517.1

申请日：2014-03-10

申请人： Qiagen Sciences, LLC

发明人： WANG, Yexun ,  DICARLO, John ,  DEVGAN, Vikram ,  JIANG, Qiong ,  PENG, Quan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6806 ,  C12Q1/6851 ,  C12Q2537/143 ,  C12Q2543/10 ,  C12Q2531/113 ,  C12Q2561/101

摘要： The present disclosure provides methods, arrays and kits for assessing the quality of genomic DNA samples, especially those obtained from formalin-fixed paraffin-embedded (FFPE) samples. The methods, arrays and kits provided herein use primer pairs specific to regions in the genomes of the organisms from which genomic DNA samples are obtained that have identical or nearly identical copies distributed across multiple chromosomes.

摘要翻译： 本公开提供用于评估基因组DNA样品的质量的方法，阵列和试剂盒，特别是从福尔马林固定的石蜡包埋（FFPE）样品获得的样品。 本文提供的方法，阵列和试剂盒使用对生物体基因组区域特异性的引物对，其中得到具有分布在多个染色体上的相同或几乎相同拷贝的基因组DNA样品。

公开(公告)号：EP2669663A4

公开(公告)日：2014-09-24

申请号：EP12739965

申请日：2012-01-24

申请人： OLYMPUS CORP

发明人： NAKATA HIDETAKA ,  NISHIKAWA KAZUTAKA

IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/78

CPC分类号： C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6886 ,  G01N21/6428 ,  G01N21/6452 ,  C12Q2525/301 ,  C12Q2543/10 ,  C12Q2563/107 ,  C12Q2565/1015 ,  C12Q2565/107 ,  C12Q2565/601

公开(公告)号：EP2675913A1

公开(公告)日：2013-12-25

申请号：EP12705595.2

申请日：2012-02-14

申请人： Bio-Rad Laboratories, Inc.

发明人： OKINO, Steven, T. ,  WANG, Yan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2521/331 ,  C12Q2523/125 ,  C12Q2535/101 ,  C12Q2543/10

摘要： This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample.

公开(公告)号：EP2556171A1

公开(公告)日：2013-02-13

申请号：EP11766613.1

申请日：2011-04-05

申请人： Prognosys Biosciences, Inc.

发明人： CHEE, Mark, S.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 ,  C12Q1/6804 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6841 ,  C12Q1/6869 ,  C12Q1/6874 ,  C40B30/04 ,  C40B60/04 ,  G01N33/5308 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q2565/515 ,  C12Q2535/122 ,  C12Q2543/10 ,  C12Q2563/179

摘要： The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

公开(公告)号：EP1689883A4

公开(公告)日：2007-10-10

申请号：EP04778619

申请日：2004-07-19

申请人： AUREON BIOSCIENCES CORP

发明人： EDELSON JON ,  CAPODIECI PAOLA

IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N33/00

CPC分类号： C12Q1/6806 ,  C07H21/04 ,  C12Q1/6841 ,  Y10S436/80 ,  Y10T436/143333 ,  C12Q2543/10 ,  C12Q2527/125 ,  C12Q2527/109

公开(公告)号：EP1549949A2

公开(公告)日：2005-07-06

申请号：EP03756478.8

申请日：2003-10-08

申请人： Vogel, Walter

发明人： Vogel, Walter

IPC分类号： G01N33/50

CPC分类号： G01N33/574 ,  C12Q1/6809 ,  C12Q1/6841 ,  G01N33/5091 ,  C12Q2543/10

摘要： The invention relates to a method for detecting and limiting breast carcinoma risk of a test person by a micronucleus test of binuclear cells with and without induction by treating the cultured cells of said test person with a mutagen.

公开(公告)号：EP1131470A1

公开(公告)日：2001-09-12

申请号：EP99971049.4

申请日：1999-10-28

申请人： VYSIS, INC. ,  The United States of America, represented by the Secretary, Department of Health and Human Services

发明人： KALLIONIEMI, Olli-P. ,  MÜLLER, Uwe, Richard ,  SAUTER, Giudo ,  KONONEN, Juha ,  BARLUND, Maarit

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00743 ,  B01L3/5085 ,  C12Q1/6809 ,  C12Q1/6837 ,  C12Q1/6841 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N1/08 ,  G01N1/2813 ,  G01N1/312 ,  G01N33/5005 ,  G01N33/54306 ,  G01N2001/282 ,  G01N2001/288 ,  G01N2001/368 ,  G02B21/34 ,  C12Q2543/10 ,  C12Q2539/103 ,  C12Q2537/157 ,  C12Q2565/501

摘要： A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue, such as susceptibility or resistance to particular types of drug treatment. Other examples of suitable tissues which can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines).

公开(公告)号：EP1038022A2

公开(公告)日：2000-09-27

申请号：EP98963881.2

申请日：1998-12-11

申请人： Digene Corporation

发明人： LORINCZ, Attila, T.

IPC分类号： C12Q1/00

CPC分类号： C12Q1/708 ,  A01N1/021 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2543/10 ,  C12Q2523/101 ,  C12Q2545/114

摘要： This invention provides novel methods for assessing HPV infection. Gene expression levels are used to the progression of HPV infection from benign to malignant growth by determining the ratio between mRNA levels of E6 and/or E7 and E2 and/or L1. Also provided are kits for carrying out the methods of this invention.