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1.发明公开MATERIALS AND METHODS FOR DIAGNOSIS OF BLADDER CANCER AND MONITORING RECURRENCE THEREOF 有权材料和膀胱癌的诊断和监测复发IT的使用方法
公开(公告)号：EP2798079A1
公开(公告)日：2014-11-05
申请号：EP12806869.9
申请日：2012-12-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： A method of diagnosing bladder cancer in a patient comprising contacting a sample of urothelial cells obtained from the patient with a set of detectably labeled probes comprising locus- specific probes for c-myc and AURKA and centromeric probes for chromosomes 7 and 17 under hybridization conditions, and determining the presence of chromosomal abnormalities, wherein the presence of chromosomal abnormalities involving at least two of the detectably labeled probes indicates that the patient has bladder cancer; a method of monitoring recurrence of bladder cancer in a patient; a set of probes comprising locus-specific probes for c-myc and AURKA and centromeric probes for chromosomes 7 and 17; and a kit comprising (a) the set of probes and (b) instructions for diagnosing bladder cancer, or monitoring the recurrence thereof, in a patient.
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2.发明公开CELL PREPARATIONS AND CELL SUPPORTS AND THEIR USE IN THERANOSIS 审中-公开ZELLPRÄPARATEUND ZERTRAGER UND DEREN VERWENDUNG IN DER THERANOSTIK
公开(公告)号：EP2971096A1
公开(公告)日：2016-01-20
申请号：EP14717930.3
申请日：2014-03-13
发明人： SOKOLOVA, Irina , SCHULZ, John , KORNFELD, Olga , PANELLA, Jeffrey , SONG, Minghao , SITAILO, Svetlana , POLICHT, Frank , BROWNE, Gerry , PESTOVA, Ekaterina
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6841 , C12Q2537/16 , C12Q2600/106 , C12Q2600/158 , G01N1/30 , G01N33/5091 , G01N33/57419 , G01N2001/305 , C12Q2527/125 , C12Q2543/10
摘要： A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support.
摘要翻译： 一种从患者标本制备细胞的方法，包括组织或细胞团; 原位杂交（ISH）或免疫组化（IHC）的方法; 一种将患者对靶向酪氨酸激酶途径的活性剂的反应的方法; 包括ISH或IHC的方法的改善方法; 其表面上的细胞载体是与ISH或IHC的方法已经与可检测标记的探针接触的细胞; 以及包含（a）细胞支持体和/或ISH或IHC的至少一个探针的试剂盒，和（b）用于在细胞支持物上进行ISH或IHC的方法的指导。
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3.发明授权MATERIALS AND METHODS FOR DIAGNOSIS OF BLADDER CANCER AND MONITORING RECURRENCE THEREOF 有权材料和膀胱癌的诊断和监测复发IT的使用方法
公开(公告)号：EP2798079B1
公开(公告)日：2016-09-07
申请号：EP12806869.9
申请日：2012-12-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112
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公开(公告)号：EP2971091A1
公开(公告)日：2016-01-20
申请号：EP14717312.4
申请日：2014-03-13
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6841 , C12Q2537/16 , C12Q2600/106 , C12Q2600/158 , G01N1/30 , G01N33/5091 , G01N33/57419 , G01N2001/305 , C12Q2527/125 , C12Q2543/10
摘要： A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support.
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