公开(公告)号：EP2167071B1

公开(公告)日：2020-03-18

申请号：EP08770940.8

申请日：2008-06-13

申请人： Wayne State University Board Of Governors ,  Phase V. Pharmaceuticals, Inc.

发明人： MEYTHALER, Jay, M. ,  TUEL, Stephen, M.

IPC分类号： A61K31/195 ,  A61K47/00 ,  A61L9/04 ,  A61K47/02 ,  A61K9/00 ,  A61K31/197 ,  A61K31/192

公开(公告)号：EP3615017A1

公开(公告)日：2020-03-04

申请号：EP18718166.4

申请日：2018-04-23

申请人： Pharnext

发明人： COHEN, Daniel ,  NABIROCHKIN, Serguei ,  HAJJ, Rodolphe ,  BRUREAU, Anthony

IPC分类号： A61K31/185 ,  A61K31/195 ,  A61K31/404 ,  A61P25/28

公开(公告)号：EP3177637B1

公开(公告)日：2020-03-04

申请号：EP15830470.9

申请日：2015-08-06

申请人： Georgia State University Research Foundation, Inc.

发明人： MERLIN, Didlier

IPC分类号： A61K38/05 ,  A61K38/06 ,  A61K31/195 ,  A61K31/451 ,  A61K31/635 ,  A61K45/06 ,  G01N33/574 ,  A61P1/04 ,  A61P35/00

摘要： The present invention relates to methods of treating a patient who has colorectal cancer and to methods of reducing the likelihood that a patient will develop or experience a recurrence of colorectal cancer. The methods comprise a step of introducing, to the patient, an effective amount of an agent that targets an intestinal H−-coupled di/tripeptide transporter (PepT1). Useful compositions including, for example, the tripeptide KPV, vectors encoding such peptides, and cells (e.g., bacterial cells) including them, are also within the scope of the present invention, as are kits including such compositions.

公开(公告)号：EP3610849A1

公开(公告)日：2020-02-19

申请号：EP18784620.9

申请日：2018-04-09

申请人： Kao Corporation

发明人： OZAWA, Toshiaki ,  SAKAI, Takaya ,  MIYOSHI, Mariko ,  FURUKAWA, Daisuke ,  SHIRAI, Aya

IPC分类号： A61K8/41 ,  A61K8/36 ,  A61K8/44 ,  A61K8/46 ,  A61K31/195 ,  A61P17/00 ,  A61P17/10 ,  A61Q19/10

摘要： Provided is a method for removing keratotic plugs capable of sufficiently exhibiting an excellent keratotic plug-removing effect without a burden, such as pain and of irritation, on the skin.
The present invention relates to a method for removing keratotic plugs comprising using a composition comprising (X) one or more selected from the group consisting of (X1) 2-amino-2-hydroxymethyl-1,3-propanediol (X2), 2-amino-2-methyl-1-propanol, and (X3) 2-amino-2-methyl-1,3-propanediol.

公开(公告)号：EP3592332A1

公开(公告)日：2020-01-15

申请号：EP18713312.9

申请日：2018-03-06

申请人： Laboratoire de Rhumatologie Appliquée

发明人： SAC-EPEE, Patrick ,  SCHOUFT, Alain ,  CONROZIER, Thierry

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/195 ,  C08L5/08

公开(公告)号：EP3582766A1

公开(公告)日：2019-12-25

申请号：EP18753852.5

申请日：2018-02-16

申请人： University Of South Florida

发明人： DAVE, Vrushank, G. ,  CAI, Jianfeng

IPC分类号： A61K31/166 ,  A61K31/175 ,  A61K31/195

公开(公告)号：EP2696678B1

公开(公告)日：2019-11-20

申请号：EP12771294.1

申请日：2012-04-16

申请人： Molecular Transfer, Inc.

发明人： JESSEE, Joel, A. ,  GEBEYEHU, Gulilat

IPC分类号： A01N37/12 ,  A01N37/44 ,  A61K31/195

公开(公告)号：EP3548086A1

公开(公告)日：2019-10-09

申请号：EP17817552.7

申请日：2017-11-30

申请人： Tyme, Inc.

发明人： HOFFMAN, Steven

IPC分类号： A61K45/06 ,  A61K31/195 ,  A61P35/00

公开(公告)号：EP3527552A1

公开(公告)日：2019-08-21

申请号：EP17850248.0

申请日：2017-09-12

申请人： Sichuan Haisco Pharmaceutical Co., Ltd.

发明人： LI, Yao ,  SHI, Zongjun ,  XU, Bo

IPC分类号： C07C229/28 ,  A61K31/195 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00

摘要： Disclosed are a fused tricyclic γ-amino acid derivative and a medical use thereof, in particular, the present invention relates to a fused cyclic γ-amino acid derivative as shown in general formula (I), or a stereoisomer, solvate, metabolite, prodrug, pharmaceutically acceptable salt or eutectic thereof, a pharmaceutical composition containing same, and the use of a compound or the composition in the field of analgesia, wherein the definitions of each substituent in general formula (I) are the same as the definitions in the description.

公开(公告)号：EP3522881A2

公开(公告)日：2019-08-14

申请号：EP17859072.5

申请日：2017-10-04

申请人： Afecta Pharmaceuticals, Inc.

发明人： KOVACS, Bruce ,  SHAHBAHRAMI, Kamron ,  NICOLA, George

IPC分类号： A61K31/195 ,  A61K31/165