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公开(公告)号：EP3185859B1
公开(公告)日：2019-07-17
申请号：EP15762523.7
申请日：2015-08-28
申请人： Pharnext
IPC分类号： A61K31/137 , A61K31/4985 , A61P25/16 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/185 , A61K31/195 , A61K31/198 , A61K31/44 , A61K45/06 , A61K9/00
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公开(公告)号：EP3459535A1
公开(公告)日：2019-03-27
申请号：EP18203488.4
申请日：2008-11-28
申请人： Pharnext
IPC分类号： A61K31/047 , A61K31/197 , A61K31/27 , A61K31/4164 , A61K31/4178 , A61K31/485 , A61K31/567 , A61K45/06 , A61P25/28
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject.
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公开(公告)号：EP2819663B1
公开(公告)日：2017-07-05
申请号：EP13706549.6
申请日：2013-02-28
申请人： Pharnext
IPC分类号： A61K31/185 , A61K31/195 , A61P25/16
CPC分类号： A61K31/519 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/185 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/403 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/44 , A61K31/4402 , A61K31/4422 , A61K31/445 , A61K31/506 , A61K45/06 , A61K31/24 , A61K2300/00 , A61K31/64 , A61K31/48 , A61K31/428 , A61K31/4045 , A61K31/485 , A61K31/135 , A61K31/165 , A61K31/5513 , A61K31/551 , A61K31/343 , A61K31/4525 , A61K31/13 , A61K31/27 , A61K31/353 , A61K31/55 , A61K31/416 , A61K31/4178 , A61K31/4458 , A61K31/505 , A61K31/4184
摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
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4.发明公开COMBINATION OF BACLOFEN, ACAMPROSATE AND MEDIUM CHAIN TRIGLYCERIDES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开巴氯芬，阿坎酸和中链甘油三酯可用于治疗神经系统疾病组合
公开(公告)号：EP3104850A1
公开(公告)日：2016-12-21
申请号：EP15705551.8
申请日：2015-02-10
申请人： Pharnext
IPC分类号： A61K31/185 , A61K31/197 , A61K31/20 , A61P25/16 , A61P25/28 , A61P25/30
CPC分类号： A61K31/23 , A61K31/185 , A61K31/197 , A61K31/20 , A61K36/185 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related Amyloid beta toxicity and/or neuronal death and/or glucose impaired neuronal metabolism. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, frontotemporal dementia, Parkinson's disease, Lewy body dementia, Huntington's disease, peripheral neuropathies, alcoholism or alcohol withdrawal, neurological manifestations of drug abuse or drug abuse withdrawal, amyotrophic lateral sclerosis, multiple sclerosis, spinal cord injury, epilepsy, traumatic brain injury or brain ischemic events based on baclofen, acamprosate and at least one medium chain triglyceride.
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公开(公告)号：EP3003268A1
公开(公告)日：2016-04-13
申请号：EP14727848.5
申请日：2014-06-05
申请人： Pharnext
IPC分类号： A61K9/00 , A61K9/08 , A61K31/7004 , A61K45/06 , A61K47/12 , A61K47/26 , A61K31/19 , A61K31/485
CPC分类号： A61K9/0053 , A61K9/0095 , A61K9/08 , A61K31/047 , A61K31/195 , A61K31/197 , A61K31/485 , A61K47/12 , A61K47/14 , A61K47/26 , A61K2300/00
摘要： The present invention relates to a homogeneous, stable, and palatable pharmaceutical solution comprising baclofen, sorbitol and naltrexone.
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公开(公告)号：EP2819663A1
公开(公告)日：2015-01-07
申请号：EP13706549.6
申请日：2013-02-28
申请人： Pharnext
IPC分类号： A61K31/137 , A61K31/138 , A61K31/185 , A61K31/195 , A61K31/42 , A61K31/64 , A61P25/16
CPC分类号： A61K31/519 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/185 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/403 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/44 , A61K31/4402 , A61K31/4422 , A61K31/445 , A61K31/506 , A61K45/06 , A61K31/24 , A61K2300/00 , A61K31/64 , A61K31/48 , A61K31/428 , A61K31/4045 , A61K31/485 , A61K31/135 , A61K31/165 , A61K31/5513 , A61K31/551 , A61K31/343 , A61K31/4525 , A61K31/13 , A61K31/27 , A61K31/353 , A61K31/55 , A61K31/416 , A61K31/4178 , A61K31/4458 , A61K31/505 , A61K31/4184
摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
摘要翻译： 本发明涉及用于治疗帕金森氏病和相关病症的组合物和方法。 更具体地说，本发明涉及帕金森病和靶向α-突触核蛋白聚集网络的相关病症的新型组合疗法。 具体而言，本发明涉及单独或组合的化合物可有效保护神经元细胞免于α-突触核蛋白聚集体的化合物。 本发明还涉及制备用于治疗帕金森病的药物或药物组合的方法以及治疗帕金森病或相关病症的方法。
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7.发明授权COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS 有权组合毛果芸香碱和甲巯咪唑FOR腓骨肌萎缩症的BEHANLDUNG及相关疾病
公开(公告)号：EP2307000B1
公开(公告)日：2014-02-26
申请号：EP09765871.0
申请日：2009-06-17
申请人： Pharnext
发明人： COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei , GUERASSIMENKO, Oxana , CHOLET, Nathalie
IPC分类号： A61K31/197 , A61K31/4178 , A61K31/4164 , A61K45/06 , A61P25/02
CPC分类号： A61K31/047 , A61K31/192 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/439 , A61K31/485 , A61K31/575 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2560631A2
公开(公告)日：2013-02-27
申请号：EP12708113.1
申请日：2012-03-01
申请人： Pharnext
IPC分类号： A61K31/137 , A61K31/138 , A61K31/185 , A61K31/195 , A61K31/42 , A61K31/64 , A61P25/16 , A61P25/28 , A61P25/00
CPC分类号： A61K31/44 , A61K9/2004 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/428 , A61K31/445 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ² toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.
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公开(公告)号：EP2211846B1
公开(公告)日：2013-02-27
申请号：EP08854467.1
申请日：2008-11-28
申请人： Pharnext
IPC分类号： A61K31/047 , A61K31/197 , A61K31/27 , A61K31/4164 , A61K31/4178 , A61K31/485 , A61K31/567 , A61K45/06 , A61P25/28
CPC分类号： A61K31/485 , A61K9/0095 , A61K9/08 , A61K9/4866 , A61K31/047 , A61K31/197 , A61K31/7004
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10.发明公开NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE 有权新的治疗方法用于治疗阿尔茨海默病及相关疾病由穿梭应激反应
公开(公告)号：EP2282779A1
公开(公告)日：2011-02-16
申请号：EP09738186.7
申请日：2009-04-29
申请人： Pharnext
CPC分类号： A61K45/06 , A61K31/137 , A61K31/155 , A61K31/167 , A61K31/185 , A61K31/343 , A61K31/423 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease.
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