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    SYNTHESIS OF HYDROFLUOROALKANOLS AND HYDROFLUOROALKENES
    51.
    发明公开
    SYNTHESIS OF HYDROFLUOROALKANOLS AND HYDROFLUOROALKENES 审中-公开
    HYDROFLUORALKENOLEN合成水合氯化氢

    公开(公告)号：EP2215097A1

    公开(公告)日：2010-08-11

    申请号：EP08851477.3

    申请日：2008-11-20

    申请人： E. I. du Pont de Nemours and Company

    发明人： NAPPA, Mario, Joseph ,  SUN, Xuehui ,  YAGUPOLSKII, Lev, Moiseevich ,  FILATOV, Andrey, Anatolievich ,  BOIKO, Vladimir, Nikolaevich ,  YAGUPOLSKII, Yurii, Lvovich

    IPC分类号： C07F3/00 ,  C07C17/363 ,  C07C23/06 ,  C07C29/40 ,  C07C31/28 ,  C07C67/08 ,  C07C69/63

    CPC分类号： C07F3/003 ,  C07C17/10 ,  C07C17/363 ,  C07C23/06 ,  C07C29/40 ,  C07C67/08 ,  C07C69/63 ,  C07C2601/04 ,  C07C19/12 ,  C07C21/18 ,  C07C31/34

    摘要： Described herein is a process for the manufacture of hydrofluoroalkanols of the structure RfCFClCHROH, comprising reacting a halofluorocarbon of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, with an aldehyde and a reactive metal in a reaction solvent to generate a reaction product comprising a metal hydrofluoroalkoxide, neutralizing said metal hydrofluoroalkoxide to produce a hydrofluoroalkanol, and recovering the hydrofluoroalkanol. Also described herein are methods of manufacturing hydrofluoroalkenes of the structure RfCF=CHR from halofluorocarbons of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, comprising (1) reacting halofluorocarbons of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, with an aldehyde and a reactive metal to generate a reaction product comprising a metal hydrofluoroalkoxide, and reductively dehydroxyhalogenating said metal hydrofluoroalkoxide to produce a hydrofluoroalkene or (2) reacting a hydrofluoroalkanol of the structure RfCFXCHROH or a hydrofluoroalkoxide of the structure RfCFXCHROMX, wherein M is a reactive metal in the +2 oxidation state, with a carboxylic acid anhydride and a reactive metal in a reaction solvent to form a hydrofluoroalkene and isolating the hydrofluoroalkene. In particular, 2,3,3,3,-tetrafluoro-1-propene may be manufactured with this process. Also described are compounds of the formula RfCFClCHROC(=O)R'.

    摘要翻译： 本文描述的是制备结构RfCFClCHROH的氢氟烷醇的方法，包括使结构RfCFX2的卤氟烃，其中每个X独立地选自Cl，Br和I与反应溶剂中的醛和反应性金属反应 产生包含金属氢氟烷氧化物的反应产物，中和所述金属氢氟烷氧化物以产生氢氟烷醇，并回收氢氟烷醇。 本文还描述了从结构RfCFX2的卤代烃制备结构RfCF = CHR的氢氟烯烃的方法，其中每个X独立地选自Cl，Br和I，其包括（1）使结构RfCFX2的卤代碳氟化合物，其中每个X是 独立地选自Cl，Br和I，与醛和反应性金属反应生成包含金属氢氟烷氧化物的反应产物，还原性地将所述金属氢氟烷氧化物脱羟基卤化产生氢氟烯烃，或（2）使结构RfCFXCHROH的氢氟烷醇或 结构RfCFXCHROMX的氢氟烷氧化物，其中M是+2氧化态的反应性金属，在反应溶剂中与羧酸酐和反应性金属反应形成氢氟烯烃并分离氢氟烯烃。 特别地，可以用该方法制造2,3,3,3-四氟-1-丙烯。 还描述了式RfCFClCHROC（= O）R'的化合物。

    ZINC CONTAINING CHEMICAL PRODUCT AND METHOD OF MAKING SAME
    55.
    发明公开
    ZINC CONTAINING CHEMICAL PRODUCT AND METHOD OF MAKING SAME 失效
    含锌化学产品和生产方法

    公开(公告)号：EP0876317A4

    公开(公告)日：1999-04-14

    申请号：EP96927424

    申请日：1996-08-16

    申请人： FERRO CORP

    发明人： DEVER JAMES L ,  GUERINI ANTHONY F JR

    IPC分类号： C07C29/70 ,  C07C31/28 ,  C07F3/00 ,  C09K15/32

    CPC分类号： C07F3/003

    摘要： The present invention provides a continuous melt process for the preparation of a unique zinc oxide/pentaerythritol chemical product that can be used as a stabilizer. The process comprises the steps of providing a continuous processor having a product feed zone, a reaction zone, and a discharge zone; feeding zinc oxide and pentaerythritol into the product feed zone and providing a raw material mixture comprising the zinc oxide and said pentaerythritol; maintaining a temperature of from about 185 DEG C to about 245 DEG C in the reaction zone; maintaining a temperature of from about 185 DEG C to about 245 DEG C in the discharge zone; transporting the raw material mixture into the reaction zone and maintaining a residence time for the raw material mixture in the transition zone of from about 10 to about 60 seconds so as to provide a reacted chemical product; transporting the reacted product into said discharge zone; and removing the reacted chemical product from the discharge zone.

    Central nervous system antiischemic agents
    56.
    发明公开
    Central nervous system antiischemic agents 失效
    中国人民解放军防盲联合会。

    公开(公告)号：EP0559569A1

    公开(公告)日：1993-09-08

    申请号：EP93400565.3

    申请日：1993-03-04

    申请人： Bristol-Myers Squibb Company

    发明人： Poindexter, Graham S.

    IPC分类号： C07C323/25 ,  C07C323/14 ,  C07C323/41 ,  C07C323/42 ,  C07C31/28 ,  A61K31/135 ,  A61K31/165

    CPC分类号： C07C323/25 ,  C07C317/28 ,  C07C323/16 ,  C07C323/41 ,  C07C323/42

    摘要： A series of phenylalkylaminoalkyl derivatives of Formula I

    wherein Ar is naphtyl or phenyl;
       R¹ is hydrogen, fluoro or R⁴CONH-;
       R² is hydrogen or C₁ - ₆ alkyl;
       R₃ is C₁ - ₆ alkyl;
       R⁴ is C₁ - ₆ alkyl or phenyl- C₁ - ₆ alkyl;
       x is zero or the integers 1 and 2;
       m is selected from the integers 1 to 6; and
       n is selected from the integers 2 and 3,
    has been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma or stroke or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.

    摘要翻译： 一系列式I的苯基烷基氨基烷基衍生物其中Ar是萘基或苯基; R 1是氢，氟或R 4 CONH-; R 2是氢或C 1-6烷基; R3是C1-6烷基; R 4是C 1-6烷基或苯基-C 1-6烷基; x为零或整数1和2; m选自整数1至6; 并且已经发现n从整数2和3中选择，为CNS组织，特别是神经元提供有效的抗缺血保护。 用于保护CNS缺血的治疗方法，例如由外伤或中风或其它缺血状况引起的CNS缺血的方法包括向需要这种治疗的个体施用这些新化合物。

    Process for preparing tin alkoxides
    59.
    发明公开
    Process for preparing tin alkoxides 失效
    制备丁烷氧化物的方法

    公开(公告)号：EP0252543A3

    公开(公告)日：1989-03-08

    申请号：EP87201065.7

    申请日：1987-06-05

    申请人： STAUFFER CHEMICAL COMPANY

    发明人： Greco, Cal Cataldo

    IPC分类号： C07C29/70 ,  C07C31/28 ,  C07C43/13

    CPC分类号： C07C29/70 ,  C07C31/28

    摘要： Tin tetra-alkoxides absent halogenic impurities are prepared by a two-step process comprising a first step reaction of tin tetrahalide with an alcohol and ammonia. A second step reacts the product of the first step with a metal amide and additional alcohol. An alternative second step reacts the product of the first step with a metal alkoxide.