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    BRAIN COOLING DEVICE ALSO HAVING FLUID DISCHARGE FUNCTION
    61.
    发明公开
    BRAIN COOLING DEVICE ALSO HAVING FLUID DISCHARGE FUNCTION 审中-公开
    麻省理工学院

    公开(公告)号：EP2815711A1

    公开(公告)日：2014-12-24

    申请号：EP13748571.0

    申请日：2013-02-06

    申请人： Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： PARK, Jae Chan ,  SUK, Kyoung Ho ,  HAN, Hyung Soo ,  RHEE, Dong Ick

    IPC分类号： A61B18/02 ,  A61M1/00 ,  A61M27/00

    CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0002 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/101 ,  A61F2007/126 ,  A61M27/00 ,  A61M27/002 ,  A61M2027/004

    摘要： In a brain cooling device according to an embodiment of the present invention, preferably, temperature sensors are installed in one end and the other end of a cooling fluid transport tube to detect a temperature, a pressure measurement sensor is installed in a storage tank, a control unit is connected to the temperature sensors and the pressure measurement sensor, and the control unit calculates an amount of heat absorbed from a brain according to a change in pressure of the storage tank and the temperature detected by the temperature sensors. In the brain cooling device according to the embodiment of the present invention, preferably, one end of the cooling fluid transport tube and a drainage tube is bent such that adjacent drainage tubes come in close contact with each other. The brain cooling device according to the present invention is directly installed in a dura mater of a brain or a site in which an operation of incising the dura mater of the brain is performed so that heat or swelling is effectively mitigated. After use of the device ends, the brain cooling device may be removed through an operation hole which allows a cooling fluid to be introduced and discharged and penetrates a scalp and a cranium and thereby the device may be removed without a separate operation. When vaporized liquid nitrogen and the like are used as the cooling fluid, it is possible to cool the brain without separate mechanical and electric devices. In addition, blood and the like accumulated in an operation area may be discharged using a drain hole installed in the cooling device.

    摘要翻译： 在根据本发明的实施例的脑冷却装置中，优选地，温度传感器安装在冷却液输送管的一端和另一端以检测温度，压力测量传感器安装在储罐中， 控制单元连接到温度传感器和压力测量传感器，并且控制单元根据存储罐的压力变化和由温度传感器检测的温度来计算从大脑吸收的热量。 在根据本发明的实施例的脑冷却装置中，优选地，冷却液输送管的一端和排水管弯曲，使得相邻的排液管彼此紧密接触。 根据本发明的脑冷却装置直接安装在大脑的硬脑膜或其中进行切开脑硬膜的手术的部位，从而有效地减轻了热量或肿胀。 在使用装置末端之后，可以通过操作孔去除脑冷却装置，该操作孔允许冷却流体被引入和排出并渗透头皮和头颅，从而可以在不进行单独操作的情况下移除装置。 当使用蒸发的液氮等作为冷却流体时，可以在没有单独的机械和电气装置的情况下冷却大脑。 此外，积存在操作区域中的血液等可以使用安装在冷却装置中的排水孔来排出。

    POLYPEPTIDE SPECIFICALLY BINDING TO PHOSPHATIDYLSERINE AND USE THEREOF
    62.
    发明授权
    POLYPEPTIDE SPECIFICALLY BINDING TO PHOSPHATIDYLSERINE AND USE THEREOF 有权
    与特异性结合其使用磷脂酰丝氨酸多肽

    公开(公告)号：EP2280024B1

    公开(公告)日：2014-12-17

    申请号：EP09714117.0

    申请日：2009-02-25

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： KIM, In San ,  LEE, Byung Heon ,  NARENDRA, Thapa

    IPC分类号： C07K7/06 ,  G01N33/574 ,  G01N33/92 ,  A61K47/48 ,  A61K49/00

    CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

    摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

    MICROSCOPE FOR MONITORING OPTICAL COHERENCE TOMOGRAPHY
    63.
    发明公开
    MICROSCOPE FOR MONITORING OPTICAL COHERENCE TOMOGRAPHY 审中-公开
    MIKROSKOP ZURÜBERWACHUNGEINER OPTISCHENKOHÄRENZTOMOGRAFIE

    公开(公告)号：EP2786697A1

    公开(公告)日：2014-10-08

    申请号：EP12852843.7

    申请日：2012-03-08

    申请人： Kyungpook National University Industry-Academic Cooperation Foundation

    发明人： KIM, Jee Hyun ,  KIM, Hong Kyun ,  LEE, Chang Ho ,  KIM, Kyung Un ,  LEE, Jun Hun ,  HAN, Seung Hoon ,  PARK, Ki Beom

    IPC分类号： A61B3/10 ,  A61B3/12 ,  A61B3/14

    CPC分类号： G02B21/361 ,  A61B3/102 ,  A61B3/13 ,  G02B21/365

    摘要： Provided is a microscope for monitoring optical coherence tomography. The microscope for monitoring optical coherence tomography includes a microscope image providing unit which is configured to include a first objective lens, a beam splitter, and an ocular lens which are sequentially disposed from the front of a sample mount and an optical coherent tomography (OCT) image providing unit which generates an OCT image and provides the OCT image to the beam splitter of the microscope image providing unit, wherein the OCT image providing unit generates the OCT image of the same position as the surface image of the sample and provides the OCT image to the beam splitter of the microscope image providing unit, and in the case where the OCT image is provided through the beam splitter to the OCT image providing unit, the microscope image providing unit simultaneously outputs the surface image and the OCT image of the sample to the ocular lens.

    摘要翻译： 提供了一种用于监测光学相干断层扫描的显微镜。 用于监测光学相干断层摄影的显微镜包括显微镜图像提供单元，该显微镜图像提供单元被配置为包括从样本安装座的前部和光学相干断层摄影（OCT）顺序地设置的第一物镜，分束器和眼睛透镜， 图像提供单元，其生成OCT图像并将OCT图像提供给显微镜图像提供单元的分束器，其中OCT图像提供单元生成与样本的表面图像相同位置的OCT图像，并提供OCT图像 到显微镜图像提供单元的分束器，并且在通过分束器向OCT图像提供单元提供OCT图像的情况下，显微镜图像提供单元同时将样本的表面图像和OCT图像输出到 眼镜。

    POLYPEPTIDE SPECIFICALLY COUPLED TO PHOSPHATIDYLSERINE AND USE THEREOF
    65.
    发明公开
    POLYPEPTIDE SPECIFICALLY COUPLED TO PHOSPHATIDYLSERINE AND USE THEREOF 有权
    多粘多糖麻醉师麻醉师BINDUNG ANPOSTISTISYIN UND ANWENDUNG DAVON

    公开(公告)号：EP2280024A2

    公开(公告)日：2011-02-02

    申请号：EP09714117.0

    申请日：2009-02-25

    申请人： Kyungpook National University Industry- Academic Cooperation Foundation

    发明人： KIM, In San ,  LEE, Byung Heon ,  NARENDRA, Thapa

    IPC分类号： C07K7/06

    CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

    摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

    摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说，涉及具有序列号1，特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为有效成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，检测含有多肽作为活性成分的凋亡细胞检测方法，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于 肿瘤区。 具有序列号1的氨基酸序列的多肽与磷脂酰丝氨酸特异性地结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。